Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of stearoyl-CoA desaturase in hypoxia-induced myocardial angiogenesis: from cell interactions to gene regulation

2015/17/D/NZ5/03446

Keywords:

angiogenesis heart ischemia/hypoxia SCD4 gene promoter progenitor cells saturated fatty acids

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ana Gan 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 733 000 PLN

Project start date (Y-m-d): 2016-03-16

Project end date (Y-m-d): 2020-03-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Zamrażarka niskotemperaturowa (-80 stopni C). (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Stearoyl-CoA desaturase 1 deficiency reduces lipid accumulation in the heart by activating lipolysis independently of peroxisome proliferator-activated receptor alpha
    Authors:
    Bednarski T, Olichwier A, Opasinska A, Pyrkowska A, Gan AM, Ntambi JM, Dobrzyn p
    Academic press:
    Biochim Biophys Acta - Mol Cell Biol Lipids (rok: 2016, tom: 12, strony: 2029-2037), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.005 - link to the publication
  2. Stearoyl-CoA desaturase regulates angiogenesis and energy metabolism in ischemic cardiomyocytes
    Authors:
    Gan AM, Tracz-Gaszewska Z, Ellert-Miklaszewska A, Navrulin VO, Ntambi JM, Dobrzyn P
    Academic press:
    Int J Mol Sci (rok: 2022, tom: 23, strony: 10459), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms231810459 - link to the publication
  1. Interplay between endothelial cells and cardiomyocytes in ischemic condition
    Authors:
    A.M. Gan, P. Dobrzyn
    Conference:
    25th Karakow Conference on Endothelium (rok: 2017, ), Wydawca: JCET
    Data:
    konferencja 20-21 październik
    Status:
    Published
  2. Role of stearoyl-CoA desaturase in cardiovascular system: alternations in cell metabolism and tissue remodeling
    Authors:
    A. Filip, A. Olichwier, M. Wołosiewicz, A.M. Gan, P. Dobrzyn
    Conference:
    60th International Conference on the Bioscience of Lipids (rok: 2019, ), Wydawca: ICBL
    Data:
    konferencja 43633
    Status:
    Published

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