Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Injectable biodegradable local drug delivery system supramolecularly cross-linked in situ with controlled drug release

2015/17/B/ST5/01086

Keywords:

biodegradable polymeric networks injectable systems of local drug delivery inclusion complex supramolecular chemistry drug/ cyclodextrin complex functional polymers

Descriptors:

  • ST5_11: Smart materials – self assembled materials, external stimuli-responsive materials
  • ST5_22:
  • ST5_21:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Centrum Materiałów Polimerowych i Węglowych PAN

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Piotr Kurcok 

Number of co-investigators in the project: 9

Call: OPUS 9 - announced on 2015-03-16

Amount awarded: 590 120 PLN

Project start date (Y-m-d): 2016-01-28

Project end date (Y-m-d): 2020-01-27

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komora rekawicowa (200 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (10)
  1. Biodegradable pH-responsive micelles loaded with 8-hydroxyquinoline glycoconjugates for Warburg effect based tumor targeting
    Authors:
    A. Domiński, M. Krawczyk, T. Konieczny, M. Kasprów, A. Foryś, G. Pastuch-Gawołek, P. Kurcok
    Academic press:
    European Journal of Pharmaceutics and Boppharmaceutics (rok: 2020, tom: 154, strony: 317-329), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejpb.2020.07.019 - link to the publication
  2. CD oxyanions as a tool for synthesis of highly anionic cyclodextrin polymers
    Authors:
    T. Girek, K. Koziel, B. Girek, W. ciesielski
    Academic press:
    Polymers (rok: 2020, tom: 12(12), strony: 2845), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12122845 - link to the publication
  3. Stimuli-Responsive Aliphatic Polycarbonate Nanocarriers for Tumor-Targeted Drug Delivery
    Authors:
    A. Domiński, T. Konieczny, K. Duale, M. Krawczyk, G. Pastuch-Gawołek, P. Kurcok
    Academic press:
    polymers (rok: 2020, tom: 12, strony: 2890), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/polym12122890 - link to the publication
  4. Bioactive oligomers from natural polyhydroxyalkanoates and their synthetic analogues
    Authors:
    G. Adamus, P. Kurcok, I. Radecka, M. Kowalczuk
    Academic press:
    Polimery (rok: 2017, tom: 62, strony: 317-322), Wydawca: IChP
    Status:
    Published
    DOI:
    10.14314/polimery.2017.317 - link to the publication
  5. α-Cyclodextrin-Based Polypseudorotaxane Hydrogels
    Authors:
    A. Domiński, T. Konieczny, P. Kurcok
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 133 (1-28)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13010133 - link to the publication
  6. Diversifying polyhydroxyalkanoates – end-group and side-chain functionality
    Authors:
    M. Michalak, I. Kwiecień, M. Kwiecień, G. Adamus, K. Odelius, M. Hakkarainen, P. Kurcok
    Academic press:
    Current Organic Synthesis (rok: 2017, tom: 14, strony: 757-767), Wydawca: Bentham
    Status:
    Published
    DOI:
    10.2174/1570179414666161115150146 - link to the publication
  7. Polihydroksyalkaniany – zastosowania i recykling
    Authors:
    P. Kurcok, M. Kawalec, M. Sobota, M. Michalak, M. Kwiecień, S. Jurczyk
    Academic press:
    Polimery (rok: 2017, tom: 62, strony: 364-370), Wydawca: IChP
    Status:
    Published
    DOI:
    10.14314/polimery.2017.364 - link to the publication
  1. Recykling organiczny prototypowych opakowań
    Authors:
    M. Musioł, W. Sikorska, J. Rydz, P. Kurcok, M. Kowalczuk
    Conference:
    Materiały Polimerowe. Pomerania-Plast 2016 (rok: 2016, ), Wydawca: Wydawnictwo Uczelniane ZUT w Szczecinie
    Data:
    konferencja 7-10.06.2016
    Status:
    Published
  2. Wstrzykiwalne, pH-czułe supramolekularne hydrożele do kontrolowanego uwalniania leku
    Authors:
    A. Domiński, T. Konieczny, M. Krawczyk, P. Kurcok
    Conference:
    8th Edition of The Conference for Young Scientists, Science Beyond Disciplines (rok: 2019, ), Wydawca: HARIT Krzysztof Bednarek
    Data:
    konferencja 19-20.09.2019
    Status:
    Published
  3. Wstrzykiwalny system lokalnego kontrolowanego uwalniania leków sieciowany supramolekularnie in situ
    Authors:
    T. Konieczny, A. Domiński, J. Jaworska, P. Kurcok
    Conference:
    8th Edition of The Conference for Young Scientists, Science Beyond Disciplines (rok: 2019, ), Wydawca: HARIT Krzysztof Bednarek
    Data:
    konferencja 19-2-.09.2019
    Status:
    Published
  4. Injectable, pH-sensitive supramolecular hydrogel for controlled drug delivery
    Authors:
    5.A. Domiński, M. Krawczyk, T. Konieczny, M. Kasprów, A. Foryś, G. Pastuch-Gawołek, P. Kurcok
    Conference:
    19th Symposium POLYMERS 2019 (rok: 2019, ), Wydawca: Institute of Polymers BAN
    Data:
    konferencja 9-12.09.2019
    Status:
    Published
  5. Nowe spojrzenie na recykling biopoliestrów
    Authors:
    P. Kurcok, M. Kawalec, M. Sobota, M. Michalak, M. Kwiecień
    Conference:
    Materiały Polimerowe. Pomerania-Plast 2016 (rok: 2016, ), Wydawca: Wydawnictwo Uczelniane ZUT w Szczecinie
    Data:
    konferencja 7-10.06.2016
    Status:
    Published
  6. Complexation of selected biologically active compounds by chosen oligosaccharides.
    Authors:
    J. Jaworska, M. Kawalec, T. Girek, T. Konieczny, K. Jelonek, A. Orchel, P. Kurcok
    Conference:
    International workshop on polymer science and polymeric materials (rok: 2017, ), Wydawca: Polymer Institute SAS
    Data:
    konferencja 10. 11.2017
    Status:
    Published
  7. Synteza kopoliwęglanów o potencjalnym zastosowaniu biomedycznym
    Authors:
    A. Domiński, T. Konieczny, P. Kurcok, J. Jaworska, M. Kawalec, K. Jelonek, T. Girek
    Conference:
    Zjazd Naukowy Polskiego Towarzystwa Chemicznego (rok: 2018, ), Wydawca: PTChem
    Data:
    konferencja 17-21 września 2018
    Status:
    Published
  8. Synthesis of propargyl-functionalized biodegradable copolymers for click-chemistry reactions
    Authors:
    T. Konieczny, M. Kawalec, J. Jaworska, K. Jelonek, T. Girek, A. Orchel, P. Kurcok
    Conference:
    International workshop on polymer science and polymeric materials (rok: 2017, ), Wydawca: Polymer Institute SAS
    Data:
    konferencja 10.11.2017
    Status:
    Published
  9. pH-responsive shell-sheddable micelles based on poly(ethylene glycol)-hydrazone-poly[R,S]-3-hydroxybutyrate copolymer for tumor-targeted drug delivery
    Authors:
    A. Domiński, M. Krawczyk, T. Konieczny, G. Pastuch-Gawołek, P. Kurcok
    Conference:
    UK-Poland Bioinspired Materials Conference (rok: 2020, ), Wydawca: LANCASTER UNIVERSITY-NEWCASTLE UNIVERSITY-AGH UNIVERSITY OF SCIENCE AND TECHNOLOGY
    Data:
    konferencja 24-24.11.2020
    Status:
    Published
  10. pH-Responsive Biodegradable Micelles for Triggered Release of Anticancer Drugs
    Authors:
    T. Konieczny, A. Domiński, M. Krawczyk, M. Kasprów, A. Foryś, P. Kurcok
    Conference:
    4th International Conference InterNANO Poland 2019 (rok: 2019, ), Wydawca: The NANONET Foundation
    Data:
    konferencja 16-17.10.2019
    Status:
    Published