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Contrasting role of Nox1/2 and Nox4 isoforms of NAPDH oxidase in the machanism of diabetes-induced oxidative stress and antioxidative effect of physical training and nitrites in diabetes.

2015/17/N/NZ5/00328

Keywords:

Diabetes mellitus Type I Oxidative stress NADPH oxidase isoforms Exercise training Superoxide Nitric oxide Nitrites.

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Centrum Medyczne Kształcenia Podyplomowego, Studium Kliniczno-Dydaktyczne

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Gajos-Draus 

Number of co-investigators in the project: 3

Call: PRELUDIUM 9 - announced on 2015-03-16

Amount awarded: 149 952 PLN

Project start date (Y-m-d): 2016-03-14

Project end date (Y-m-d): 2019-06-13

Project duration:: 39 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (1)
  1. Cardiac and renal upregulation of Nox2 and NF-κB and repression of Nox4 and Nrf2 in season- and diabetes-mediated models of vascular oxidative stress in guinea-pig and rat.
    Authors:
    Anna Gajos-Draus, Monika Duda, Andrzej Beręsewicz
    Academic press:
    Physiological Reports (rok: 2017, tom: 5, strony: 20), Wydawca: Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society
    Status:
    Published
    DOI:
    10.14814/phy2.13474 - link to the publication
  2. New concepts of the pro-atherogenetic mechanism of vascular oxidative stress. Protective and harmful roles of NADPH oxidase.
    Authors:
    Anna Gajos-Draus
    Academic press:
    Postępy Nauk Medycznych (rok: 2016, tom: 29, strony: 52-56), Wydawca: Wydawnictwo Medyczne Borgis
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Exercise and nitrite prevent and Nω-nitrol-L-arginine methyl ester reproduces imbalance in the nuclear factor-κB/NADPH oxidase 2 and nuclear factor erythroid 2-related factor 2/NADPH oxidase 4/endothelial nitric oxide synthase systems in diabetes.
    Authors:
    Gajos-Draus A, Duda M, Beresewicz A.
    Academic press:
    J Physiol Pharmacol. (rok: 2021, tom: 72(5), strony: n/a), Wydawca: Polish Physiological Society, formerly as Acta Physiologica Polonica
    Status:
    Published
    DOI:
    10.26402/jpp.2021.5.03 - link to the publication
  1. Exercise Training and Dietary Nitrite Prevent and L-NAME Mimics Diabetes-Mediated Upregulation of Nox2/NF-κB and Repression of Nox4/Nrf2 in Rat Heart and Kidney.
    Authors:
    Anna Gajos-Draus, Monika Duda, Andrzej Beręsewicz
    Conference:
    3rd Joint Meeting of the European Society for Microcirculation (ESM) and the European Vascular Biology Organization (EVBO), Maastricht, April 2019 (rok: 2019, ), Wydawca: Karger in the Journal of Vascular Research
    Data:
    konferencja 15-18.04.2019
    Status:
    Published

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