Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of kynurenine pathway in neurophatic pain in view of innovative treatment approaches

2015/17/D/NZ4/02284

Keywords:

Kmo kynurenine pathway neurophatic pain minocycline pain pharmacology

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii im. Jerzego Maja Polskiej Akademii Nauk

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewelina Rojewska 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 841 000 PLN

Project start date (Y-m-d): 2016-02-12

Project end date (Y-m-d): 2022-02-11

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr UV/VIS do mikroobjętości wraz z oprogramowaniem do analizy DNA, RNA i białek (55 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (15)
  1. Kinureniny w ośrodkowym układzie nerwowym a ból neuropatyczny – kliniczne implikacje badań podstawowych.
    Authors:
    Ciapała K., Rojewska E.
    Academic press:
    Ból (rok: 2019, tom: 20, strony: 45294), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    - - link to the publication
  2. ZAPRINAST DIMINISHED PAIN AND ENHANCED OPIOID ANALGESIA IN A RAT NEUROPATHIC PAIN MODEL
    Authors:
    Ewelina Rojewska, Anna Piotrowska, Agnieszka Jurga, Wioletta Makuch, Joanna Mika
    Academic press:
    European Journal of Pharmacology (rok: 2018, tom: 15, strony: 21-32), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2018.09.001 - link to the publication
  3. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.
    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Joanna Mika
    Academic press:
    Pharmacological Reports (rok: 2019, tom: -, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.002 - link to the publication
  4. The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives
    Authors:
    Katarzyna Ciapała, Joanna Mika, Ewelina Rojewska
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 13, strony: 45309), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011055 - link to the publication
  5. Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model
    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Academic press:
    Frontiers in Pharmacology (rok: 2018, tom: -, strony: -), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00724. - link to the publication
  6. Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain
    Authors:
    Katarzyna Ciapała, Katarzyna Pawlik, Agata Ciechanowska, Joanna Mika, and Ewelina Rojewska
    Academic press:
    Toxicology and Applied Pharmacology (rok: 2023, tom: 461, strony: ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  1. Importance of kynurenic pathway enzymes in neuropathic pain development in rats
    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: CEBC
    Data:
    konferencja 15-18.09.2018
    Status:
    Published
  2. Inhibition of kynurenine 3-monooxygenase significantly reduces neuropathic pain and intensifies its pharmacological treatment.
    Authors:
    Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch., Barbara Przewocka, Joanna Mika.
    Conference:
    2nd Central European Biomedical Congress (rok: 2016, ), Wydawca: CEBC
    Data:
    konferencja 15-18.06.2016
    Status:
    Published
  3. Minocycline affects neuropathic pain by regulation of kynurenic pathway - role of microglial cells
    Authors:
    Ewelina Rojewska, Anna Piotrowska, Agnieszka M. Jurga, Wioletta Makuch, Barbara Przewłocka, Joanna Mika
    Conference:
    13-sty Międzynarodowy Zjazd Polskiego Towarzystwa Badań Układu Nerwowego (rok: 2017, ), Wydawca: PTBUN
    Data:
    konferencja 28.08-31.08. 2017
    Status:
    Published
  4. Profiling the gene expression alterations following minocycline administration in a rat model of neuropathic pain
    Authors:
    Rojewska Ewelina, Piotrowska-Murzyn Anna, Korostynski Michal, Przewlocki Ryszard, Przewlocka Barbara, Mika Joanna
    Conference:
    Międzynarodowa Konferencja Neurochemiczna "Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation. Novel therapeutic approaches" (rok: 2018, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 19-20.10.2018
    Status:
    Published
  5. Zaprinast reduced pain and enhanced opioid analgesia in a rat neuropathic pain model
    Authors:
    Katarzyna Ciapała, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
    Conference:
    Neuronus 2018 IBRO NEUROSCIENCE FORUM (rok: 2018, ), Wydawca: IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22-.04.2018
    Status:
    Published
  6. Antinociceptive effects of pharmacological kynurenine-3-monooxygenase inhibition by UPF-648 and its influence on opioids effectiveness in neuropathic pain.
    Authors:
    Ciapala K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research "From Lab to clinic" (rok: 2019, ), Wydawca: Index Copernicus International
    Data:
    konferencja 22-27.06.
    Status:
    Published
  7. Pharmacological modulation of kynurenic pathway by Ro61-6048 and JM6 significantly diminishes neuropathic pain symptoms.
    Authors:
    Rojewska Ewelina, Piotrowska Anna, Makuch Wioletta, Przewlocka Barbara, Mika Joanna
    Conference:
    The 6th International Congress on Neuropathic Pain (NeuPSIG 2017) (rok: 2017, ), Wydawca: IASP
    Data:
    konferencja 15.06.-18.06.2017
    Status:
    Published
  8. Antinociceptive effects of zaprinast and its influences on opioids analgesia in neuropathic rats
    Authors:
    Katarzyna Ciapała, Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Conference:
    3rd Central European Biomedical Congress (rok: 2018, ), Wydawca: CEBC
    Data:
    konferencja 15-18.09.2018
    Status:
    Published
  9. Modulation of the kynurenine pathway in search for antinociceptive agents. Focus on kynurenine 3-monooxygenase
    Authors:
    Ewelina Rojewska, Anna Piotrowska, Barbara Przewlocka, Joanna Mika
    Conference:
    INTERDISCIPLINARY JUNIOR SCIENTISTS WORKSHOP ON NEUROPHARMACOLOGY AND MOLECULAR BIOLOGY (rok: 2017, ), Wydawca: IF PAN, KNOW, MIBMiK
    Data:
    konferencja 29.03-01.04
    Status:
    Published
  10. The importance of kynurenine 3-monooxygenase activated in spinal microglia for neuropathic pain
    Authors:
    Rojewska Ewelina, Piotrowska Anna, Mika Joanna
    Conference:
    XIII European Meeting on Glial Cells in Health and Disease (GLIA 2017) (rok: 2017, ), Wydawca: Wiley
    Data:
    konferencja 08.07-11.07.2017
    Status:
    Published
  11. Pharmacological modulation of kynurenic pathway by Ro61-6048 diminished neuropathic pain in a rat model.
    Authors:
    Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch, Agnieszka M. Jurga, Barbara Przewlocka, Joanna Mika
    Conference:
    10th Fens Forum of Neuroscience (rok: 2016, ), Wydawca: FENS
    Data:
    konferencja 2-6.07. 2016
    Status:
    Published
  12. Gpr35 agonist (zaprinast) inhibits neuropathic pain-related behavior and upregulation of pronociceptive factors in a rat model
    Authors:
    Ewelina Rojewska, Anna Piotrowska, Agnieszka Jurga, Wioletta Makuch, Joanna Mika
    Conference:
    Neuronus 2018 IBRO NEUROSCIENCE FORUM (rok: 2018, ), Wydawca: IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 20-22-.04.2018
    Status:
    Published
  13. KYNURENIC ACID AND ZAPRINAST DIMINISHED CXCL17-EVOKED PAIN-RELATED BEHAVIOUR IN NAÏVE ANIMALS
    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Joanna Mika
    Conference:
    Neuronus (rok: 2020, ), Wydawca: IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 8-11.12
    Status:
    Published
  14. KYNURENIC ACID AND ZAPRINAST INFLUENCED PAIN-RELATED BEHAVIOR AND MORPHINE EFFECTIVENESS IN A MOUSE MODEL OF NEUROPATHIC PAIN
    Authors:
    Katarzyna Ciapała, Ewelina Rojewska, Joanna Mika
    Conference:
    NEURONUS (rok: 2020, ), Wydawca: IBRO NEUROSCIENCE FORUM
    Data:
    konferencja 8-11.12
    Status:
    Published
  15. Pharmacological kynurenine 3-monooxygenase enzyme Inhibition by UPF-648 significantly reduces neuropathic pain and enhanced opioid analgesia in a rat model.
    Authors:
    Ciapała K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (rok: 2019, ), Wydawca: EHRS
    Data:
    konferencja 15-18.05.
    Status:
    Published

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