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The role of kynurenine pathway in neurophatic pain in view of innovative treatment approaches

2015/17/D/NZ4/02284

Keywords

Descriptors

  • NZ4_4: Patofizjologia ogólna
  • NZ4_12: Inne zagadnienia pokrewne

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Farmakologii PAN

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Ewelina Joanna Rojewska

Number of co-investigators in the project: 3

Call

SONATA 9 – announced on 2015-03-16

Amount awarded
841 000 PLN
Project start date
2016-02-12
Project end date
2022-02-11
Project duration
72 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Spektrofotometr UV/VIS do mikroobjętości wraz z oprogramowaniem do analizy DNA, RNA i białek. Cost: 55 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Kinureniny w ośrodkowym układzie nerwowym a ból neuropatyczny – kliniczne implikacje badań podstawowych.

    Authors:
    Ciapała K., Rojewska E.
    Academic press:
    Ból (year: 2019, volume: 20, pages: 46025), Publisher: Index Copernicus International
    Status:
    Published

  2. ZAPRINAST DIMINISHED PAIN AND ENHANCED OPIOID ANALGESIA IN A RAT NEUROPATHIC PAIN MODEL

    Authors:
    Ewelina Rojewska, Anna Piotrowska, Agnieszka Jurga, Wioletta Makuch, Joanna Mika
    Academic press:
    European Journal of Pharmacology (year: 2018, volume: 15, pages: 21-32), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2018.09.001 – link to the publication

  3. Pharmacological Inhibition of Indoleamine 2,3-Dioxygenase-2 and Kynurenine 3-Monooxygenase, Enzymes of the Kynurenine Pathway, Significantly Diminishes Neuropathic Pain in a Rat Model

    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Academic press:
    Frontiers in Pharmacology (year: 2018, volume: -, pages: -), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2018.00724. – link to the publication

  4. Kynurenic acid and zaprinast diminished CXCL17-evoked pain-related behaviour and enhanced morphine analgesia in a mouse neuropathic pain model.

    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Joanna Mika
    Academic press:
    Pharmacological Reports (year: 2019, volume: -, pages: -), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2018.10.002 – link to the publication

  5. The Kynurenine Pathway as a Potential Target for Neuropathic Pain Therapy Design: From Basic Research to Clinical Perspectives

    Authors:
    Katarzyna Ciapała, Joanna Mika, Ewelina Rojewska
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 13, pages: 46040), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms222011055 – link to the publication

  6. Effect of pharmacological modulation of the kynurenine pathway on pain-related behavior and opioid analgesia in a mouse model of neuropathic pain

    Authors:
    Katarzyna Ciapała, Katarzyna Pawlik, Agata Ciechanowska, Joanna Mika, and Ewelina Rojewska
    Status:
    Accepted for publication

Articles in post-conference publications (15)

  1. Pharmacological kynurenine 3-monooxygenase enzyme Inhibition by UPF-648 significantly reduces neuropathic pain and enhanced opioid analgesia in a rat model.

    Authors:
    Ciapała K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    48th meeting of the European Histamine Research Society (year: 2019, pages: 96), Publisher: EHRS
    Date:
    conference 15-18.05.
    Status:
    Published

  2. Zaprinast reduced pain and enhanced opioid analgesia in a rat neuropathic pain model

    Authors:
    Katarzyna Ciapała, Ewelina Rojewska, Wioletta Makuch, Joanna Mika
    Conference:
    Neuronus 2018 IBRO NEUROSCIENCE FORUM (year: 2018, pages: www.neuronusorum.pl), Publisher: IBRO NEUROSCIENCE FORUM
    Date:
    conference 20-22-.04.2018
    Status:
    Published

  3. Antinociceptive effects of pharmacological kynurenine-3-monooxygenase inhibition by UPF-648 and its influence on opioids effectiveness in neuropathic pain.

    Authors:
    Ciapala K., Rojewska E., Piotrowska A., Pawlik K., Makuch W., Mika J.
    Conference:
    European Pain Federation Krakow Pain School, EFIC School 2019, Translational Pain Research From Lab to clinic (year: 2019, pages: 17), Publisher: Index Copernicus International
    Date:
    conference 22-27.06.
    Status:
    Published

  4. Antinociceptive effects of zaprinast and its influences on opioids analgesia in neuropathic rats

    Authors:
    Katarzyna Ciapała, Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Conference:
    3rd Central European Biomedical Congress (year: 2018, pages: http://if-pan.krakow.pl/cebc/), Publisher: CEBC
    Date:
    conference 15-18.09.2018
    Status:
    Published

  5. Importance of kynurenic pathway enzymes in neuropathic pain development in rats

    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Anna Piotrowska, Wioletta Makuch, Joanna Mika
    Conference:
    3rd Central European Biomedical Congress (year: 2018, pages: http://if-pan.krakow.pl/cebc/), Publisher: CEBC
    Date:
    conference 15-18.09.2018
    Status:
    Published

  6. Gpr35 agonist (zaprinast) inhibits neuropathic pain-related behavior and upregulation of pronociceptive factors in a rat model

    Authors:
    Ewelina Rojewska, Anna Piotrowska, Agnieszka Jurga, Wioletta Makuch, Joanna Mika
    Conference:
    Neuronus 2018 IBRO NEUROSCIENCE FORUM (year: 2018, pages: www.neuronusorum.pl), Publisher: IBRO NEUROSCIENCE FORUM
    Date:
    conference 20-22-.04.2018
    Status:
    Published

  7. The importance of kynurenine 3-monooxygenase activated in spinal microglia for neuropathic pain

    Authors:
    Rojewska Ewelina, Piotrowska Anna, Mika Joanna
    Conference:
    XIII European Meeting on Glial Cells in Health and Disease (GLIA 2017) (year: 2017, pages: http://www.glia2017.eu/), Publisher: Wiley
    Date:
    conference 08.07-11.07.2017
    Status:
    Published

  8. Pharmacological modulation of kynurenic pathway by Ro61-6048 and JM6 significantly diminishes neuropathic pain symptoms.

    Authors:
    Rojewska Ewelina, Piotrowska Anna, Makuch Wioletta, Przewlocka Barbara, Mika Joanna
    Conference:
    The 6th International Congress on Neuropathic Pain (NeuPSIG 2017) (year: 2017, pages: http://neupsig2017.kenes.com/), Publisher: IASP
    Date:
    conference 15.06.-18.06.2017
    Status:
    Published

  9. KYNURENIC ACID AND ZAPRINAST DIMINISHED CXCL17-EVOKED PAIN-RELATED BEHAVIOUR IN NAÏVE ANIMALS

    Authors:
    Ewelina Rojewska, Katarzyna Ciapała, Joanna Mika
    Conference:
    Neuronus (year: 2020, pages: -), Publisher: IBRO NEUROSCIENCE FORUM
    Date:
    conference 8-11.12
    Status:
    Published

  10. Pharmacological modulation of kynurenic pathway by Ro61-6048 diminished neuropathic pain in a rat model.

    Authors:
    Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch, Agnieszka M. Jurga, Barbara Przewlocka, Joanna Mika
    Conference:
    10th Fens Forum of Neuroscience (year: 2016, pages: http://forum2016.fens.org/), Publisher: FENS
    Date:
    conference 2-6.07. 2016
    Status:
    Published

  11. Inhibition of kynurenine 3-monooxygenase significantly reduces neuropathic pain and intensifies its pharmacological treatment.

    Authors:
    Ewelina Rojewska, Anna Piotrowska, Wioletta Makuch., Barbara Przewocka, Joanna Mika.
    Conference:
    2nd Central European Biomedical Congress (year: 2016, pages: http://if-pan.krakow.pl/cebc/), Publisher: CEBC
    Date:
    conference 15-18.06.2016
    Status:
    Published

  12. KYNURENIC ACID AND ZAPRINAST INFLUENCED PAIN-RELATED BEHAVIOR AND MORPHINE EFFECTIVENESS IN A MOUSE MODEL OF NEUROPATHIC PAIN

    Authors:
    Katarzyna Ciapała, Ewelina Rojewska, Joanna Mika
    Conference:
    NEURONUS (year: 2020, pages: -), Publisher: IBRO NEUROSCIENCE FORUM
    Date:
    conference 8-11.12
    Status:
    Published

  13. Modulation of the kynurenine pathway in search for antinociceptive agents. Focus on kynurenine 3-monooxygenase

    Authors:
    Ewelina Rojewska, Anna Piotrowska, Barbara Przewlocka, Joanna Mika
    Conference:
    INTERDISCIPLINARY JUNIOR SCIENTISTS WORKSHOP ON NEUROPHARMACOLOGY AND MOLECULAR BIOLOGY (year: 2017, pages: http://if-pan.krakow.pl/assets/files/), Publisher: IF PAN, KNOW, MIBMiK
    Date:
    conference 29.03-01.04
    Status:
    Published

  14. Minocycline affects neuropathic pain by regulation of kynurenic pathway - role of microglial cells

    Authors:
    Ewelina Rojewska, Anna Piotrowska, Agnieszka M. Jurga, Wioletta Makuch, Barbara Przewłocka, Joanna Mika
    Conference:
    13-sty Międzynarodowy Zjazd Polskiego Towarzystwa Badań Układu Nerwowego (year: 2017, pages: http://icpns2017.conrego.pl/), Publisher: PTBUN
    Date:
    conference 28.08-31.08. 2017
    Status:
    Published

  15. Profiling the gene expression alterations following minocycline administration in a rat model of neuropathic pain

    Authors:
    Rojewska Ewelina, Piotrowska-Murzyn Anna, Korostynski Michal, Przewlocki Ryszard, Przewlocka Barbara, Mika Joanna
    Conference:
    Międzynarodowa Konferencja Neurochemiczna Advances in molecular and epigenetic mechanisms in neurodegeneration and neuroinflammation. Novel therapeutic approaches (year: 2018, pages: -), Publisher: Polskie Towarzystwo Biochemiczne
    Date:
    conference 19-20.10.2018
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski