Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulation of RNA polymerase III in macrophages

2015/17/D/NZ1/00034

Keywords:

transcription RNA polimerase III macrophages NF-kappaB MAP kinases

Descriptors:

  • NZ1_1: Molecular biology
  • NZ3_1: Cell biology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Damian Graczyk 

Number of co-investigators in the project: 3

Call: SONATA 9 - announced on 2015-03-16

Amount awarded: 776 000 PLN

Project start date (Y-m-d): 2016-06-01

Project end date (Y-m-d): 2020-09-30

Project duration:: 52 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Dewar do przechowywania komórek Taylor–Wharton LS3000 (20 000 PLN)
  2. Komputery.
  3. Inkubator CO2 do hodowli komórkowych.
  4. Wirówka Eppendorf 5424R z chłodzeniem (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Regulation of tRNA synthesis by the general transcription factors of RNA polymerase III - TFIIIB and TFIIIC, and by the MAF1 protein
    Authors:
    Graczyk D., Cieśla M., Boguta M.
    Academic press:
    Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (rok: 2018, tom: 1861, strony: 320-329), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2018.01.011 - link to the publication
  2. MAP kinases are involved in RNA polymerase III regulation upon LPS treatment in macrophages
    Authors:
    Aneta Jurkiewicz, Damian Graczyk
    Academic press:
    Gene (rok: 2022, tom: 831, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.gene.2022.146548 - link to the publication
  3. Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid
    Authors:
    Jurkiewicz A., Leśniewska E., Cieśla M, Gorjão N, Kantidakis T, White RJ, Boguta M, Graczyk D.
    Academic press:
    Molecular and Cellular Biology (rok: 2019, tom: 40, strony: 45305), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/MCB.00294-1 - link to the publication

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