Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Air Pollution versus Autoimmunity: Role of multiphase aqueous Inorganic Chemistry (APARIC)

2015/16/W/ST5/00005

Keywords:

air pollution biochemistry catalysis computational chemistry DFT calculations environmental chemistry inorganic/bioinorganic redox chemistry molecular modeling multiphase aqueous chemistry nanoparticles photocatalysis photochemistry transition metal complexes transition metal containing particulate matter ultrafine particles atherosclerosis autoimmune diseases autoimmunity biological cell tests clinical experiments collagen induced arthritis endothelium expression profiling gene networks immunology inflammation lymphocytes monocytes macrophages neurology neuropharmacology novel genes pharmacology transcriptional markers Treg and Th17 subsets

Descriptors:

  • ST5_16:
  • ST5_13: Research methods on materials/nanomaterials properties
  • ST5_24:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Rudi van Eldik 

Number of co-investigators in the project: 37

Call: SYMFONIA 3

Amount awarded: 6 960 560 PLN

Project start date (Y-m-d): 2015-11-20

Project end date (Y-m-d): 2021-09-19

Project duration:: 70 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Autoklaw (50 000 PLN)
  2. Laptop (4 999 PLN)
  3. Aparat "dot blot" (15 000 PLN)
  4. Klatka NexGen.
  5. Ssak laboratoryjny.
  6. Stacja robocza do cytometru.
  7. pH-metr.
  8. Aparat "Western-blot".
  9. Cytometr (400 000 PLN)
  10. HPLC (120 000 PLN)
  11. Sterylizator parowy z przelotową komorą sterylizacyjną (150L) (130 000 PLN)
  12. Stolik Peltiera do skaningowego mikroskopu elektronowego (45 000 PLN)
  13. System 4-ro kanałowy do badania tkanek o budowie tubularnej (miograf naczyniowy) (130 000 PLN)
  14. System do programowalnej, wziewnej ekspozycji zwierząt laboratoryjnych na podawane substancje (120 000 PLN)
  15. Wirówka (40 000 PLN)
  16. Aparatura do zautomatyzowanej analizy chodu i motoryki zwierząt (185 000 PLN)
  17. Inkubator CO2 (50 000 PLN)
  18. Inkubator CO2 do hodowli komórkowych (50 000 PLN)
  19. Spektrofotometr UV.
  20. Stacja usuwania ściółki (52 000 PLN)
  21. Stacja wymiany klatek dla myszy wraz z dodatkowym wyposażeniem.
  22. System oczyszczania wody.
  23. Szafa wentylowana do hodowli myszy z wyposażeniem (klatki) (75 000 PLN)
  24. Zestaw laboratoryjny do pracy z nanocząstkami (23 000 PLN)

Information in the final report

  • Publication in academic press/journals (21)
  1. Spectroscopic Evidence for Ligand Substitution Reactions at the Solid– Liquid Interface of a Sub-micrometer Gold(I) Carbene Complex
    Authors:
    D.Langford, M. Durovic´, M. Oszajca, J. Kuncewicz, R.van Eldik
    Academic press:
    Angewandte Chemie Int. Ed. (rok: 2018, tom: 57, strony: 663-667), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.201708945 - link to the publication
  2. Generation of hydroxyl radicals and singlet oxygen by particulate matter. Chemical composition, morphology and potential health hazard
    Authors:
    Magdalena Mikrut, Olga Mazuryk, Wojciech Macyk, Rudi van Eldik, Grażyna Stochel
    Academic press:
    Environmental Pollution (rok: 2020, tom: brak, strony: brak), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Air particulate matter SRM 1648a primes macrophages to hyperinflammatory response after LPS stimulation
    Authors:
    Anna Gawda, Grzegorz Majka, Bernadeta Nowak, Małgorzata Śróttek, Maria Walczewska, Janusz Marcinkiewicz
    Academic press:
    Inflammation Research (rok: 2018, tom: 67, strony: 765-776), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00011-018-1165-4 - link to the publication
  4. Bioinorganic antimicrobial strategies in the resistance era
    Authors:
    A. Regiel-Futyra, J.M. Dąbrowski, O. Mazuryk, K. Śpiewak, A. Kyzioł, B. Pucelik, M. Brindell, G. Stochel
    Academic press:
    Coord. Chem. Rev. (rok: 2017, tom: 351, strony: 76-117), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2017.05.005 - link to the publication
  5. Chemical composition of submicron and fine particulate matter collected in Krakow, Poland. Consequences for the APARIC project
    Authors:
    L. Samek, L. Furman, M. Mikrut, A. Regiel-Futyra, W. Macyk, G. Stochel, R. van Eldik
    Academic press:
    Chemosphere (rok: 2017, tom: 187, strony: 430-439), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2017.08.090 - link to the publication
  6. Influence of Krakow Winter and Summer Dusts on the Redox Cycling of Vitamin B12a in the Presence of Ascorbic Acid
    Authors:
    J. Polaczek, A. Jodłowska, G. Stochel, R. van Eldik
    Academic press:
    Atmosphere (rok: 2021, tom: 12 art. 1050, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/atmos12081050 - link to the publication
  7. Influence of aqueous extracts of urban air pollution on the structure and function of human serum albumin
    Authors:
    Olga Mazuryk, Przemysław Gajda-Morszewski, Monika Flejszar, Przemysław Łabuz, Rudi van Eldik, Grażyna Stochel, Małgorzata Brindell
    Academic press:
    Environmental Pollution (rok: 2020, tom: 263, strony: art. 114667, 1-8), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.envpol.2020.114667 - link to the publication
  8. Inorganic reaction mechanisms. A personal journey
    Authors:
    C. D. Hubbard, D. Chatterjee, M. Oszajca, J. Polaczek, O. Impert, M. Chrzanowska, A. Katafias, R. Puchta, R. van Eldik
    Academic press:
    Dalton Transaction (rok: 2020, tom: 49, strony: 4599-4659), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c9dt04620h - link to the publication
  9. Physicochemical Analysis of Water Extracts of Particulate Matter from Polluted Air in the Area of Kraków, Poland
    Authors:
    M. Mikrut, W. Macyk, R. van Eldik, G. Stochel
    Academic press:
    Atmosphere (rok: 2021, tom: 12 art. 565, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/atmos12050565 - link to the publication
  10. Air pollution, oxidative stress, and exacerbation of autoimmune diseases
    Authors:
    A.Gawda, G. Majka, B. Nowak, J. Marcinkiewicz
    Academic press:
    Central European Journal of Immunology (rok: 2017, tom: 42(3), strony: 305-312), Wydawca: Termedia Publishing House
    Status:
    Published
    DOI:
    10.5114/ceji.2017.70975 - link to the publication
  11. The air we breathe: air pollution as a prevalent proinflammatory stimulus contributing to neurodegeneration
    Authors:
    Monika Jankowska-Kieltyka, Adam Roman, Irena Maria Nalepa
    Academic press:
    Frontiers in Cellular Neuroscience, section Cellular Neuropathology (rok: 2021, tom: 15 art. 647643, strony: 45310), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fncel.2021.647643 - link to the publication
  12. Urban Particulate Matter-Induced Decomposition of S-Nitrosoglutathione Relevant to Aberrant Nitric Oxide Biological Signaling
    Authors:
    Maria Oszajca, Anna Wądołek, James Hooper, Małgorzata Brindell, Rudi van Eldik, Grażyna Stochel
    Academic press:
    ChemSusChem (rok: 2019, tom: 12, strony: 661-671), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cssc.201802201 - link to the publication
  13. Variations in reactive oxygen species generation by inorganic and organic fractions of particulate matter in lung epithelial cells
    Authors:
    Olga Mazuryk, Grażyna Stochel, Małgorzata Brindell
    Academic press:
    Frontiers in Chemistry (rok: 2020, tom: 8, strony: art. nr 581752, 1-20), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fchem.2020.581752 - link to the publication
  14. Can Particulate Matter and Nano Metal Oxide Particles Affect the Redox Cycling of Nitrosylcobalamin in Weakly Acidic Aqueous Solution?
    Authors:
    J. Polaczek, G. Stochel, R. van Eldik
    Academic press:
    Eur. J. Inorg. Chem. (rok: 2021, tom: 2021, strony: 2325–2333), Wydawca: Wiley-VCH GmbH
    Status:
    Published
    DOI:
    10.1002/ejic.202100026 - link to the publication
  15. Metabolic Response of RAW 264.7 Macrophages to Exposure to Crude Particulate Matter and a Reduced Content of Organic Matter
    Authors:
    Jankowska-Kieltyka M., Roman A., Mikrut M., Kowalska M., van Eldik R., Nalepa I.
    Academic press:
    Toxics (rok: 2021, tom: 9 art. 205, strony: 45308), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/toxics9090205 - link to the publication
  16. Transition Metal Containing Particulate Matter Promotes Th1 and Th17 Inflammatory Response by Monocyte Activation in Organic and Inorganic Compounds Dependent Manner
    Authors:
    Adrianna Gałuszka, Małgorzata Stec, Kazimierz Węglarczyk, Anna Kluczewska, Maciej Siedlar, Jarek Baran
    Academic press:
    Int. J. Environmental Research and Public Health (rok: 2020, tom: 17, 1227, strony: 45308), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.3390/ijerph17041227 - link to the publication
  17. Air pollution and atherosclerosis — a brief review of mechanistic links between atherogenesis and biological actions of inorganic part of particulate matter
    Authors:
    K. Stachyra, A. Kiepura, R. Olszanecki
    Academic press:
    FOLIA MEDICA CRACOVIENSIA (rok: 2017, tom: LVII(3), strony: 37-46), Wydawca: PubMed Journals
    Status:
    Published
    DOI:
    brak - link to the publication
  18. Generation of hydroxyl radicals and singlet oxygen by particulate matter and its inorganic components
    Authors:
    Magdalena Mikrut, Anna Regiel-Futyra, Lucyna Samek, Wojciech Macyk, Grażyna Stochel, Rudi van Eldik
    Academic press:
    Environmental Pollution (rok: 2018, tom: 238, strony: 638-646), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.envpol.2018.03.068 - link to the publication
  19. Inhaled silica nanoparticles exacerbate atherosclerosis through skewing macrophage polarization towards M1 phenotype
    Authors:
    K. Stachyra, A. Wiśniewska, A. Kiepura, K. Kuś, F. Rolski, K. Czepiel, Ł. Chmura, G. Majka, M. Surmiak, J. Polaczek, R. van Eldik, M. Suski, R. Olszanecki
    Academic press:
    Ecotoxicology and Environmental Safety (rok: 2022, tom: 230 art. 113112, strony: 45303), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ecoenv.2021.113112 - link to the publication
  20. Lepiej poznać, by lepiej leczyć – zwierzęce modele stwardnienia rozsianego
    Authors:
    Jankowska Monika, Irena Nalepa
    Academic press:
    Wszechświat (rok: 2018, tom: 119, nr 10-12, strony: 244-254), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
    DOI:
    brak - link to the publication
  21. The influence of redox-active transition metal containing micro- and nano-particles on the properties of representative bioinorganic reaction systems
    Authors:
    Mirjana Djurovic, Maria Oszajca, Grazyna Stochel, and Rudi van Eldik
    Academic press:
    Eur. J. Inorg. Chem. (rok: 2018, tom: brak, strony: 1229-1235), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ejic.201701421 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy