Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Analysis of changes in reward system activity during unpredictable stress in a model of less and more anxious animals - how the emotionality level entails the predisposition to substance abuse?

2014/15/B/NZ4/05305

Keywords:

reward system unpredictable stress amphetamine sensitisation amygdala individual differences

Descriptors:

  • NZ4_7: Neurophysiology
  • NZ4_9: Systems neurobiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Psychiatrii i Neurologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Małgorzata Lehner 

Number of co-investigators in the project: 8

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 799 875 PLN

Project start date (Y-m-d): 2015-08-06

Project end date (Y-m-d): 2020-02-05

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat stereotaktyczny wraz z cyfrowym kontrolerem precyzji koordynatów. (78 000 PLN)
  2. Homgenizator kulkowy do tkanek firmy ROCHE (39 015 PLN)
  3. Waga analityczna (14 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (1)
  1. Corticotropin releasing factor receptor 1 antagonist differentially inhibits freezing behavior and changes GABergic activity in the amygdala in low- and high-anxiety rats.
    Authors:
    Skórzewska A, Wisłowska-Stanek A, Lehner M, Turzyńska D, Sobolewska A, Krząścik P, Płaznik A.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2017, tom: 68, strony: 12), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    nie - link to the publication
  2. The effect of a corticotropin-releasing factor receptor 1 antagonist on the fear conditioning response in low- and high-anxiety rats after chronic corticosterone administration.
    Authors:
    Anna Skórzewska, Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Danuta Turzyńska, Alicja Sobolewska, Paweł Krząścik, Janusz Szyndler, Piotr Maciejak, Adam Płaźnik
    Academic press:
    Stress (rok: 2018, tom: 20, strony: 45301), Wydawca: Taylor@Francis Taylor@Francis Group
    Status:
    Published
    DOI:
    10.1080/10253890.2018.1505857 - link to the publication
  3. Chronic stress changes prepulse inhibition after amphetamine challenge: the role of the dopaminergic system.
    Authors:
    Lehner MH,Gryz M, Karaś-Ruszczyk K, Zakrzewska A, Chmielewska N, Wisłowska-Stanek A, Skórzewska A, Turzyńska D, Sobolewska A, Mierzejewski P, Płaźnik A.
    Academic press:
    Journal of Physiology and Pharmacology (rok: 2018, tom: 10, strony: brak informacji), Wydawca: Polish Physiological Society
    Status:
    Published
    DOI:
    10.26402/jpp.2018.3.15 - link to the publication
  4. Individual susceptibility or resistance to posttraumatic stress disorder-like behaviours.
    Authors:
    Anna Skórzewska, Małgorzata Lehner, Aleksandra Wisłowska-Stanek, Danuta Turzyńska, Alicja Sobolewska, Paweł Krząścik, Janusz Szyndler, Piotr Maciejak, Natalia Chmielewska, Karolina Kołosowska, Adam Płaźnik
    Academic press:
    Behavioural Brain Research (rok: 2020, tom: 386, strony: 45305), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2020.112591 - link to the publication
  5. The co-expression of GluN2B subunits of the NMDA receptors and glucocorticoid receptors after chronic restraint stress in low and high anxiety rats.
    Authors:
    Lehner M, Wisłowska-Stanek A, Gryz M, Sobolewska A, Turzyńska D, Chmielewska N, Krząścik P, Skórzewska A, Płaźnik A.
    Academic press:
    Behavioral Brain Research (rok: 2017, tom: 319, strony: 124-134), Wydawca: Journal Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2016.11.004 - link to the publication
  6. The amphetamine-associated context exerts a stronger motivational effect in low-anxiety rats than in high-anxiety rats.
    Authors:
    LehnerM, Gryz M, Wisłowska-Stanek A, Turzyńska D, Sobolewska A, Skórzewska A, Płaźnik A.
    Academic press:
    Behavioural Brain Research (rok: 2017, tom: 330, strony: 97-107), Wydawca: Journal Elvevier
    Status:
    Published
    DOI:
    10.1016/j.bbr.2017.05.012. - link to the publication
  7. Differences in the dopaminergic reward system of rats passively and actively behave in the Porsolt test.
    Authors:
    Aleksandra Wisłowska-Stanek, Małgorzata Lehner, Karolina Kołosowska, Anna Skórzewska, Danuta Turzyńska, Monika Liguz-Lęcznar, Paweł Krząściik, Marek Gryz, Janusz Szyndler, Alicja Sobolewska,Adam Płaźnik
    Academic press:
    Behavioural Brain Research (rok: 2019, tom: 259, strony: 181-189), Wydawca: Journal Elsevier
    Status:
    Published
    DOI:
    nie - link to the publication
  8. Dopaminergic system activity under stress condition – seeking individual differences, preclinical studies
    Authors:
    Gryz M, Lehner M, Wisłowska-Stanek A, Płaźnik A.
    Academic press:
    Psychiatria Polska (rok: 2017, tom: 52, strony: 459-470), Wydawca: Polskie Towarzystwo Psychiatryczne
    Status:
    Published
    DOI:
    10.12740/PP/80500 - link to the publication
  9. Low-anxiety rats are more sensitive to amphetamine in comparison to high-anxiety rats.
    Authors:
    Lehner MH, Taracha E, Kaniuga E, Wisłowska-Stanek A, Gryz M, Sobolewska A, Turzyńska D, Skorzewska A, Płaźnik A.
    Academic press:
    Journal of Psychopharmacology (rok: 2017, tom: 31, strony: 115-126), Wydawca: SAGE Journals
    Status:
    Published
    DOI:
    10.1177/0269881116667708 - link to the publication
  1. Prepulse inhibition in 'low' and 'high' rats: the role of the dopaminergic system.
    Authors:
    Lehner M, Wisłowska-Stanek A, Chmielewska N, Skorzewska A, Mierzejewski P, Płaźnik A.
    Conference:
    Stress in Health and Disease (rok: 2018, ), Wydawca: BMI Symposia, EPFL, Lausanne
    Data:
    konferencja 14-15 March
    Status:
    Published
    DOI:
    link to the publication

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