Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Identification and functional analysis of factors secreted by oligodendrocyte progenitors in response to rat CNS injury evoked by perinatal asphyxia.

2014/15/B/NZ4/01875

Keywords:

oligodendrocyte progenitors myelination physiological normoxia perinatal asphyxia immunomodulation neuroprotection

Descriptors:

  • NZ4_9: Systems neurobiology
  • NZ4_10: Neuroimaging and computational neuroscience
  • NZ4_5: Anatomical pathology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Sypecka 

Number of co-investigators in the project: 7

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 650 000 PLN

Project start date (Y-m-d): 2015-07-09

Project end date (Y-m-d): 2019-01-08

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Separator magnetyczny komórek MiniMACS (Miltenyi Biotec) (12 000 PLN)
  2. Łaźnia wodna (3 259 PLN)
  3. Wytrząsarka orbitalna MTS 2/4 (IKA) (5 000 PLN)
  4. Inkubator NU-5840E (38 000 PLN)
  5. Wirówka Vortex (1 450 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. A simple, xeno-free method for oligodendrocyte generation from human neural stem cells derived from umbilical cord: engagement of gelatinases in cell commitment and differentiation.
    Authors:
    Sypecka Joanna, Ziemka-Nalecz Malgorzata, Dragun-Szymczak Patrycja, Zalewska Teresa
    Academic press:
    Journal of Tissue Engineering and Regenerative Medicine (rok: 2017, tom: 11(5), strony: 1442-1455), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/term.2042. - link to the publication
  2. Impact of neonatal hypoxia-ischaemia on oligodendrocyte survival, maturation and myelinating potential.
    Authors:
    Ziemka-Nalecz M, Janowska J, Strojek L, Jaworska J, Zalewska T, Frontczak-Baniewicz M, Sypecka J.
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2018, tom: 22(1), strony: 207-222), Wydawca: John Wiley & Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/jcmm.13309 - link to the publication
  3. The Differentiation of Rat Oligodendroglial Cells Is Highly Influenced by the Oxygen Tension: In Vitro Model Mimicking Physiologically Normoxic Conditions.
    Authors:
    Janowska J, Ziemka-Nalecz M, Sypecka J.
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19(2), strony: pii: E331.), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19020331. - link to the publication
  4. The potential neuroprotective role of a histone deacetylase inhibitor, sodium butyrate, after neonatal hypoxia-ischemia.
    Authors:
    Jaworska J, Ziemka-Nalecz M, Sypecka J, Zalewska T.
    Academic press:
    J Neuroinflammation (rok: 2017, tom: 14(1), strony: 34 (1-17)), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12974-017-0807-8 - link to the publication
  5. Mesenchymal cells of umbilical cord and umbilical cord blood as a source of human oligodendrocyte progenitors.
    Authors:
    Sypecka Joanna, Sarnowska Anna
    Academic press:
    Life Sciences (rok: 2015, tom: 139, strony: 24-29), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.lfs.2015.08.006. - link to the publication
  6. Therapeutic Strategies for Leukodystrophic Disorders Resulting from Perinatal Asphyxia: Focus on Myelinating Oligodendrocytes.
    Authors:
    Janowska J, Sypecka J
    Academic press:
    Molecular Neurobiology (rok: 2018, tom: 55(5), strony: 4388-4402), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-017-0647-7. - link to the publication
  7. Oligodendrocyte Response to Pathophysiological Conditions Triggered by Episode of Perinatal Hypoxia-Ischemia: Role of IGF-1 Secretion by Glial Cells
    Authors:
    Janowska j, Gargas J, Ziemka-Nalecz M, Zalewska T, Sypecka J
    Academic press:
    Molecular Neurobiology (rok: 2020, tom: 57(10), strony: 4250-4268), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-020-02015-z - link to the publication
  8. Sodium Butyrate, a Histone Deacetylase Inhibitor, Exhibits Neuroprotective/Neurogenic Effects in a Rat Model of Neonatal Hypoxia-Ischemia.
    Authors:
    Ziemka-Nalecz M, Jaworska J, Sypecka J, Polowy R, Filipkowski RK, Zalewska T.
    Academic press:
    Molecular Neurobiology (rok: 2017, tom: 54(7), strony: 5300-5318), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12035-016-0049-2 - link to the publication
  9. Directed glial differentiation and transdifferentiation for neural tissue regeneration.
    Authors:
    Janowska J, Gargas J, Ziemka-Nalecz M, Zalewska T, Buzanska L, Sypecka J.
    Academic press:
    Experimental Neurology (rok: 2018, tom: 319, strony: 112813), Wydawca: Elseviere
    Status:
    Published
    DOI:
    10.1016/j.expneurol.2018.08.010 - link to the publication

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