Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Identification and structural characterization of the primordial cytotoxic conformers of the amyloidogenic cascade: Ideal prevention/diagnostic/therapeutic targets in neurodegeneration

2014/15/Z/NZ1/00037

Keywords:

neurodegeneracy single-molecule force microscopy molecular dynamics neurotoxic proteins amyloidogenesis

Descriptors:

  • ST3_19:
  • ST3_17: Other related subjects
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Fizyki PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Cieplak 

Number of co-investigators in the project: 1

Call: UNISONO

Amount awarded: 545 941 PLN

Project start date (Y-m-d): 2015-03-12

Project end date (Y-m-d): 2019-03-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (11)
  1. Disordered peptide chains in an alpha-C-based course-grained model
    Authors:
    Ł. Mioduszewski, M. Cieplak
    Academic press:
    Phys. Chem. Chem. Phys (rok: 2018, tom: 20, strony: 19057-19070), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8cp03309a - link to the publication
  2. Stability of structurally entangled protein dimers
    Authors:
    Y. Zhao, M. Cieplak
    Academic press:
    Proteins: Structure, Function and Bioinformatics (rok: 2018, tom: 86, strony: 945-955), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/prot.25526 - link to the publication
  3. Elastic moduli of biological fibers in a coarse-grained model: crystalline cellulose and beta-amyloids
    Authors:
    A. Poma, M. Chwastyk, M. Cieplak
    Academic press:
    Phys. Chem. CVhem. Phys. (rok: 2017, tom: 19, strony: 28195-28206), Wydawca: Royal Society of Chemistyry
    Status:
    Published
    DOI:
    10.1039/C7CP05269C - link to the publication
  4. Structural entanglements in protein complexes
    Authors:
    Y. Zhao, M. Chwastyk, M. Cieplak
    Academic press:
    J. Chem. Phys. (rok: 2017, tom: 146, strony: 225102), Wydawca: AIP Publishing
    Status:
    Published
    DOI:
    10.1063/1.4985221 - link to the publication
  5. Structural fluctuations and thermal stability of proteins in crowded environments: effects of the excluded volume
    Authors:
    A. Starzyk, M. Wojciechowski, M. Cieplak
    Academic press:
    Physical Biology (rok: 2016, tom: 13, strony: 66002), Wydawca: Institute of Physics (UK)
    Status:
    Published
    DOI:
    10.1088/1478-3975/13/6/066002 - link to the publication
  6. Criteria for folding in structure-based models of proteins
    Authors:
    K. Wołek, M. Cieplak
    Academic press:
    J. Chem. Phys. (rok: 2016, tom: 144, strony: 185102), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4948783 - link to the publication
  7. Dynamics of knotted and entangled proteins
    Authors:
    M. Cieplak
    Academic press:
    Postępy Fizyki (rok: 2018, tom: 69, strony: 45359), Wydawca: Polskie Towarzystwo Fizyczne
    Status:
    Published
    DOI:
    brak - link to the publication
  8. Multiple folding pathways of proteins with shallow knots and co-translational folding
    Authors:
    M. Chwastyk, M. Cieplak
    Academic press:
    J. Chem. Phys. (rok: 2015, tom: 142, strony: 145102), Wydawca: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.4927153 - link to the publication
  9. Proteins at air-water and oil-water interfaces in an all-atom model
    Authors:
    Y. Zhao, M. Cieplak
    Academic press:
    Phys. Chem. Chem. Phyds. (rok: 2017, tom: 19, strony: 25197-25206), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C7CP03829A - link to the publication
  10. Topological transformations in proteins: effects of heating and proximity of an interface
    Authors:
    Y. Zhao, M. Chwastyk, M. Cieplak
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 39851), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep39851 - link to the publication
  11. Unfolding knots by the proteasomes: behavior of folded and neurotoxic proteins
    Authors:
    M. Wojciechowski, A. Gomez-Sicilia, M. Carrion-Vazquez, M. Cieplak
    Academic press:
    Molecular Biosystems (rok: 2016, tom: 12, strony: 2700-2712), Wydawca: Royal Chemical Society
    Status:
    Published
    DOI:
    10.1039/c6mb00214e - link to the publication

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