Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Function of BRM ATPase - the core subunit of SWI/SNF chromatin remodeling complex in control of glucose metabolism genes expression FBP1 and PKM in triple negative breast cancer.

2014/15/B/NZ5/03532

Keywords:

TNBC SWI/SNF glucose metabiolism

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_9: Other related subjects
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Janusz Siedlecki 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 169 040 PLN

Project start date (Y-m-d): 2015-07-21

Project end date (Y-m-d): 2021-07-20

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. termocykler.
  2. komplet pipet (9 000 PLN)
  3. speedvac - pompa z próżnią (50 000 PLN)
  4. zestaw do macierzy tkankowych (20 000 PLN)
  5. mikrotom.
  6. mikrowirówka z chłodzeniem (20 000 PLN)
  7. zasilacz do aparatów do elektroforezy (6 000 PLN)
  8. termomikser (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (3)
  1. PD-L1 Overexpression, SWI/SNF Complex Deregulation, and Profound Transcriptomic Changes Characterize Cancer-Dependent Exhaustion of Persistently Activated CD4 + T Cells
    Authors:
    Iga Jancewicz 1, Joanna Szarkowska 1, Ryszard Konopinski 1, Malgorzata Stachowiak 1, Monika Swiatek 1, Katarzyna Blachnio 2, Szymon Kubala 3, Paulina Oksinska 3, Pawel Cwiek 3, Natalia Rusetska 4, Agnieszka Tupalska 1 5, Natalia Zeber-Lubecka 6 7, Ewa Grabowska 1, Bianka Swiderska 3, Agata Malinowska 3, Michal Mikula 6, Beata Jagielska 8, Jan Walewski 9, Janusz A Siedlecki 4, Tomasz J Sarnowski 3, Sergiusz Markowicz 1, Elzbieta A Sarnowska 1
    Academic press:
    Cancers (rok: 2021, tom: 13, strony: 4148), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13164148 - link to the publication
  2. Effects of BRCA Germline Mutations on Triple-Negative Breast Cancer Prognosis
    Authors:
    Katarzyna Pogoda 1, Anna Niwińska 1, Elżbieta Sarnowska 2, Dorota Nowakowska 3, Agnieszka Jagiełło-Gruszfeld 1, Janusz Siedlecki 2, Zbigniew Nowec
    Academic press:
    Journal of Oncology (rok: 2020, tom: 18, strony: 8545643), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2020/8545643 - link to the publication
  3. SWI/SNF chromatin remodeling complex and glucose metabolism are deregulated in advanced bladder cancer.
    Authors:
    Stachowiak M, Szymanski M, Ornoch A, Jancewicz I, Rusetska N, Chrzan A, Demkow T, Siedlecki JA, Sarnowski TJ, Sarnowska E.
    Academic press:
    UBMB Life (rok: 2020, tom: Jun;72(6), strony: 1175-1188.), Wydawca: Wiley-Blackwell
    Status:
    Published
    DOI:
    10.1002/iub.2254 - link to the publication
  4. Advanced adenoid cystic carcinoma (ACC) is featured by SWI/SNF chromatin remodeling complex aberrations
    Authors:
    Beata Jagielska, Elzbieta Sarnowska, Natalia Rusetska, Iga Jancewicz, Monika Durzynska, Szymon Kubala, Ewa chmielik, Piuotr Paul, Tomasz Rutkowski, Tomasz J. Sarnowski, Janusz A. Siedlecki
    Academic press:
    Journal of Cancer Research and Clinical Oncology (rok: 2019, tom: 145, strony: 201-211), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00432-018-2783-5. - link to the publication
  5. Zaburzenia metabolizmu i funkcji enzymów metabolicznych a proces nowotworzenia
    Authors:
    Elżbieta Sarnowska, Marcin Leszczyński, Ewelina Macech-Klicka, Małgorzata Stachowiak, Janusz A. Siedlecki
    Academic press:
    NOWOTWORY Journal of Oncology (rok: 2016, tom: volume 66,, strony: 151-159), Wydawca: VIA MEDICA
    Status:
    Published
    DOI:
    10.5603/NJO.2016.0024 - link to the publication
  1. The role of SWI/SNF chromatin remodelling complex ATPase subunit - BRM in TNBC
    Authors:
    I Jancewicz N Rusetska A Armatowska M Stachowiak K Pogoda A Niwińska W Olszewski Z I Nowecki T J Sarnowski E Sarnowska J A Siedlecki
    Conference:
    ESMO2018 (rok: 2018, ), Wydawca: Ovford Academic
    Data:
    konferencja pażdziernik
    Status:
    Published
  2. SWI/SNF remodelling complex promotes triple negative breast cancer progression
    Authors:
    Iga Jancewicz, Elżbieta A. Sarnowska, Nataliia Rusetska, Aleksandra Gos, Tomasz J. Sarnowski, Janusz A. Siedlecki
    Conference:
    BIO 2016 Congress (rok: 2016, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 13-16 września
    Status:
    Published
    DOI:
    link to the publication
  3. The mTOR kinase directly regulates FBP1 gene expression via interaction with SWI/SNF chromatin remodeling complex in clear cell renal cell carcinoma (ccRCC).
    Authors:
    Sarnowska E, Cwiek P, Szarkowska J,Leszczynski M,Rusetska, Szymanski M, Jancewicz I.,Stachowiak M., Kubala S, Chrzan A, Gos A,Balcerak A, Demkow T,Siedlecki JA, Sarnowski TJ
    Conference:
    ESUR19 -26th Meeting of the EAU Section of Urological Research (rok: 2019, ), Wydawca: Elsevier
    Data:
    konferencja 10-12 October
    Status:
    Published
    DOI:
    link to the publication

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