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DNA repair pathways contributing to resistance to photodynamic therapy and as possible theraupeutic targets

2014/15/B/NZ5/01444

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Instytut Biochemii i Biofizyki PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Elżbieta Speina

Number of co-investigators in the project: 7

Call

OPUS 8 – announced on 2014-09-15

Amount awarded
1 016 830 PLN
Project start date
2015-07-21
Project end date
2019-07-20
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy białek wraz z transferem. Cost: 10 000 PLN
  2. Aparat do real time PCR. Cost: 75 000 PLN
  3. Komputer PC z drukarką. Cost: 5 000 PLN
  4. Waga analityczna. Cost: 4 700 PLN
  5. Wirówka z chłodzeniem. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. The role of the N-terminal domain of human apurinic/apyrimidinic endonuclease 1, APE1, in DNA glycosylase stimulation.

    Authors:
    Kladova OA, Bazlekowa-Karaban M, Baconnais S, Piétrement O, Ishchenko AA, Matkarimov BT, Iakovlev DA, Vasenko A, Fedorova OS, Le Cam E, Tudek B, Kuznetsov NA, Saparbaev M.
    Academic press:
    DNA Repair (Amst). (year: 2018, volume: 64, pages: 46320), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dnarep.2018.02.001. – link to the publication

  2. Lipid peroxidation in face of DNA damage, DNA repair and other cellular processes

    Authors:
    Barbara Tudek, Daria Zdżalik-Bielecka, Agnieszka Tudek, Konrad Kosicki, Anna Fabisiewicz, Elżbieta Speina
    Academic press:
    Free Radical Biology and Medicine (year: 2017, volume: 107, pages: 77-89), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2016.11.043 – link to the publication

  3. Increased DNA repair capacity augments resistance of glioblastoma cells to photodynamic therapy

    Authors:
    Somayeh Shahmoradi Ghahe, Konrad Kosicki, Maria Wojewódzka, Bartosz A Majchrzak, Anna Fogtman, Roksana Iwanicka-Nowicka, Agata Ciuba, Marta Koblowska, Marcin Kruszewski, Barbara Tudek, Elżbieta Speina
    Academic press:
    DNA Repair (year: 2021, volume: 104, pages: 103136), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dnarep.2021.103136 – link to the publication

  4. Mechanism of stimulation of DNA binding of the transcription factors by human apurinic/apyrimidinic endonuclease 1, APE1.

    Authors:
    Milena Bazlekowa-Karabana, Paulina Prorok, Sonia Baconnaise, Sabira Taipakova, Zhiger Akishev, Dominika Zembrzuska, Alexander V. Popov, Anton V. Endutking, Regina Groismana, Alexander A. Ishchenkoa, Bakhyt T. Matkarimovi, Amangeldy Bissenbaev, Eric Le Came, Dmitry O. Zharkov, Barbara Tudek, Murat Saparbaev
    Status:
    Accepted for publication

Articles in post-conference publications (16)

  1. Lipid Peroxidation Can Influence the Phenotype of Fanconi Anemia Cells Through Direct Inhibition of DNA Damage Signaling Proteins

    Authors:
    Elżbieta Speina, Ewelina Borsuk, Martyna Ciepielak, Barbara Tudek
    Conference:
    THE 12TH INTERNATIONAL CONFERENCE & ASIAN CONGRESS ON ENVIRONMENTAL MUTAGENS with the 33' Annual Meeting of KSOT/KEMS (year: 2017, pages: PO01-56), Publisher: Asian Society on Environmental Mutagens
    Date:
    conference 12-16 listopada
    Status:
    Published

  2. The role of human DNA repair protein APE1/Ref-1 in transcriptional regulation of genes involved in cancer development

    Authors:
    Milena Bazlekowa-Karaban, Paulina Prorok, Sonia Baconnais, Sabira Taipakova, Zhiger Akishev, Amangeldy Bissenbaev, Alexander A. Ishchenko, Eric Le Cam, Barbara Tudek, Murat Saparbaev
    Conference:
    6TH EU-US CONFERENCE on repair endogenous DNA damage (year: 2017, pages: 35/P39), Publisher: University of Udine
    Date:
    conference 24-28 września
    Status:
    Published

  3. DNA damage response genes offer possible target for the therapy of cancer cells resistant to photodynamic therapy (PDT)

    Authors:
    Konrad Kosicki, Somayeh Shahmoradi, Marta Bak, Anna Fogtman, Roksana Iwanicka-Nowicka, Marta Koblowska, Barbara Tudek
    Conference:
    6TH EU-US CONFERENCE on repair endogenous DNA damage (year: 2017, pages: 47/P83), Publisher: University of Udine
    Date:
    conference 24-28 września
    Status:
    Published

  4. Higher capacity of DNA repair promotes resistance to the photodynamic therapy in U-87 glioblastoma cell line

    Authors:
    Somayeh Shahmoradi Ghahe, Konrad Kosicki, Marta Bak, Maria Wojewodzka, Barbara Tudek
    Conference:
    Brain Tumors, from biology to therapy (year: 2018, pages: 75), Publisher: Nencki Institute of Experimental Biology, Neurobiology Center
    Date:
    conference 21-23 czerwca
    Status:
    Published

  5. Zmiany w komórkach towarzyszące nabywaniu oporności na trapię fotodynamiczną

    Authors:
    Beata Mossakowska, Anna Fabisiewicz, Janusz Siedlecki, Barbara Tudek
    Conference:
    Perspektywy w onkologii molekularnej III Zjazd Centrum Onkologii – Instytutu im. Marii Skłodowskiej – Curie (year: 2018, pages: 81), Publisher: Centrum Onkologii – Instytutu im. Marii Skłodowskiej – Curie
    Date:
    conference 5 – 6 kwietnia
    Status:
    Published

  6. DNA demethylation and BER pathway genes offer possible target for the therapy of cancer cells resistant to photodynamic therapy (PDT)

    Authors:
    Konrad Kosicki, Somayeh Shahmoradi-Ghahe, Marta Bąk, Anna Fottman Fogtman, Roksana Iwanicka-Nowicka, Marta Koblowska, Barbara Tudek
    Conference:
    46th EEMGS/30th GUM Meeting (year: 2018, pages: 69), Publisher: European Environmental Mutagenesis & Genomics Society, Gesellschaft fur Umwelt-Mutationsforschung e.V.
    Date:
    conference 18-21 marca
    Status:
    Published

  7. The role of epigenetic mark profile, cell cycle alteration and DNA repair in resistance of glioblastoma cells to photodynamic therapy (PDT)

    Authors:
    Somayeh Shahmoracii Chahe, Agata Ciuba, Karolina Kopania, Marek Foksinski, Ryszard Olinski, Barbara Tudek
    Conference:
    EACR-AACR-SIC SPECIAL CONFERENCE 2017 (year: 2017, pages: 602), Publisher: EACR-AACR
    Date:
    conference 24-27 czerwca
    Status:
    Published

  8. The role of epigenetic mark profile, cell cycle alteration and DNA repair in resistance of glioblastoma cells to photodynamic therapy

    Authors:
    Shahmoradi Ghane, Karolina Kopania, Agata Ciuba, Marek Foksinski, Ryszard Oliński, Barbara Tudek
    Conference:
    American Association for Cancer Research Annual Meeting (year: 2017, pages: 526/2049), Publisher: AACR
    Date:
    conference 1-5 kwietnia
    Status:
    Published

  9. The Role of Human DNA Repair Protein APEl/Ref-1 In Transcriptional Regulation of Genes Involved in Cancer Development

    Authors:
    Milena Bazlekowa, Somayeh Shahmoradi Ghahe, Paulina Prorok, Zhiger Akishev, Bakhyt T. Matkarimov, Olga A. Kladova, Nikita A. Kuznetsov, Alexander A. Ishchenko, Dominika Zembrzuska, Barbara Tudek, Murat Saparbaev
    Conference:
    43rd ISOBM ANNUAL CONGRESS (year: 2016, pages: S10), Publisher: International Society of Oncology and Biomarkers
    Date:
    conference 1-6 września
    Status:
    Published

  10. Resistance to photodynamic therapy in glioblastoma cancer cells

    Authors:
    Somayeh Shahmoradi Ghane, Bartosz Majchrzak, Karolina Kopania, Agata Ciuba, Barbara Tudek
    Conference:
    24th Biennial Congress of the European Association for Cancer Research (year: 2016, pages: S141), Publisher: European Association for Cancer Research
    Date:
    conference 1-6 września
    Status:
    Published

  11. Higher capacity of DNA repair promotes resistance to the photodynamic therapy in U-87 glioblastoma cell line

    Authors:
    Shahmoradi-Ghahe Somayeh, Kosicki Konrad, Bak Marta, Wojewódzka Maria, Tudek Barbara
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (year: 2018, pages: 45-46), Publisher: Institute of Biochemistry and Biophysics, Polish Academy of Sciences
    Date:
    conference 13-14 września
    Status:
    Published

  12. The role of DNA repair protein APE1/Ref1 in transcriptional regulation of genes in B-cell lymphoma cells treated with photodynamic therapy

    Authors:
    Milena Bazlekowa-Karaban, Matylda Izert, Roksana Iwanicka-Nowicka, Agnieszka Gromadka, Barbara Tudek, Murat Saparbaev
    Conference:
    13th 3R Meeting, Replication – Repair – Recombination, from Molecular Mechanisms to Clinical Applications (year: 2019, pages: P10), Publisher: CEA (Commission (Commissariat à l'énergie atomique et aux énergies alternatives), CNRS (Centre national de la recherche scientifique) i INSERM (Institut national de la santé et de la recherche médicale)
    Date:
    conference 21-24 maja
    Status:
    Published

  13. DNA repair capacity is increased in glioblastoma and cervical carcinoma cells resistant to photodynamic therapy

    Authors:
    Elżbieta Speina, Somayeh Shahmoradi Ghahe
    Conference:
    The 5th Warsaw Conference on Perspectives of Molecular Oncology: Molecular Immunology of Cancer (year: 2020, pages: Brak), Publisher: Maria Sklodowska-Curie National Research Institute of Oncology
    Date:
    conference 23-24 września
    Status:
    Published

  14. The role of epigenetic mediated gene silencing in resistance to photodynamic therapy

    Authors:
    1.Somayeh Shahmoradi-Ghan, Konrad Kosicki, Ewelina Zarakowska, Ryszard Oliński, Brabara Tudek
    Conference:
    Young Scientific Conference on Molecular and Cell Biology (year: 2019, pages: 67), Publisher: International Institute of Molecular and Cellular Biology, Warszawa, Polska
    Date:
    conference 11 kwietnia
    Status:
    Published

  15. The role of DNA repair protein APE1/Ref-1 in transcriptional regulation of genes in mouse B – cell lymphoma cells treated with photodynamic therapy

    Authors:
    Bazlekowa-Karaban Milena, Izert Matylda, Iwanicka-Nowicka Roksana, Gromadka Agnieszka, Tudek Barbara, Saparbaev Murat
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (year: 2018, pages: 26), Publisher: Institute of Biochemistry and Biophysics, Polish Academy of Sciences
    Date:
    conference 13-14 września
    Status:
    Published

  16. APE1 repair domain inhibitors in cancer treatment

    Authors:
    Mossakowska Beata, Fabisiewicz Anna, Siedlecki Janusz, Tudek Barbara
    Conference:
    9th Central European Genome Stability and Dynamics Meeting (year: 2018, pages: 39), Publisher: Instytut Biochemii i Biofizyki, Polish Academy of Sciences
    Date:
    conference 13-14 września
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski