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Oxidative stress during thermogenesis in laboratory mice with genetic variation in maximum and basal metabolic rate: the role of UCP1 protein

2014/15/B/NZ8/00244

Keywords:

oxidative stress metabolic rate thermogenesis UCP1 artificial selection

Descriptors:

  • NZ8_1:

Panel:

NZ8 - Evolutionary and environmental biology: evolution, ecology, population biology, biodiversity, biogeography

Host institution :

Uniwersytet w Białymstoku, Wydział Biologii

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Paweł Robert Brzęk 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 686 980 PLN

Project start date (Y-m-d): 2015-08-07

Project end date (Y-m-d): 2020-02-06

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (5)
  1. Significance of variation in basal metabolic rate in laboratory mice for translational experiments
    Authors:
    Paweł Brzęk, Andrzej Gębczyński, Piotr Selewestruk, Aneta Książek, Julita Sadowska, Marek Konarzewski
    Academic press:
    Journal of Comparative Physiology B (rok: 2022, tom: 192, strony: 161–169), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00360-021-01410-9 - link to the publication
  2. Divergent selection for basal metabolic rate in mice affects the abundance of UCP1 protein: implications for translational studies
    Authors:
    Paweł Brzęk, Piotr Selewestruk, Julita Sadowska, Andrzej K. Gębczyński, Aneta Książek, Anastasia Kalinovitch, Jan Nedergaard, Marek Konarzewski
    Academic press:
    Journal of Physiology (rok: 2025, tom: 603, strony: 319-336), Wydawca: Wiley-Blackwell, The Physiological Society
    Status:
    Published
    DOI:
    10.1113/JP286669 - link to the publication
  3. Mice selected for a high basal metabolic rate evolved larger guts but not more efficient mitochondria
    Authors:
    Paweł Brzęk, Damien Roussel, Marek Konarzewski
    Academic press:
    Proceedings of the Royal Society B (rok: 2022, tom: 289, strony: 20220719), Wydawca: the Royal Society
    Status:
    Published
    DOI:
    10.1098/rspb.2022.0719 - link to the publication
  4. Sex differences in nonshivering thermogenesis in the wild
    Authors:
    Paweł Brzęk
    Academic press:
    Molecular and Cellular Endocrinology (rok: 2021, tom: 536, strony: 111402), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2021.111402 - link to the publication
  1. Capacity of non-shivering thermogenesis in laboratory mice with genetic variation in maximum and basal metabolic rate
    Authors:
    Paweł Brzęk, Julita Sadowska, Andrzej Gębczyński, Piotr Selewestruk, Jan Nedergaard, Marek Konarzewski
    Conference:
    Annual Meeting of the Society for Experimental Biology, Florencja (rok: 2018, ), Wydawca: Society for Experimental Biology
    Data:
    konferencja 3-6 lipca
    Status:
    Published
  2. Physiological and Behavioral Correlates of Selection for High Swim-Induced Peak Metabolic Rate in Laboratory Mice: Implications for the Aerobic Capacity Model of the Evolution of Endothermy
    Authors:
    Brzęk P., Selewestruk P., Gębczyński A., Książek A., Sadowska J., Nedergaard J., Konarzewski M.
    Conference:
    Annual Meeting of the Society for Integrative and Comparative Biology (SICB) (rok: 2018, ), Wydawca: Oxford University Press
    Data:
    konferencja 2018
    Status:
    Published
  3. Divergent selection for basal metabolic rate in laboratory mice affected the amount of UCP1 protein
    Authors:
    Brzęk P., Selewestruk P., Nedergaard J., Konarzewski M.
    Conference:
    Annual Meeting of the Society for Integrative and Comparative Biology (SICB) (rok: 2019, ), Wydawca: Oxford University Press
    Data:
    konferencja 2019
    Status:
    Published
    DOI:
    link to the publication
  4. Effect of ambient temperature on spontaneous locomotor activity and daily energy expenditure in mice divergently selected for high and low basal metabolic rate
    Authors:
    Paweł Brzęk, Andrzej Gębczyński, Julita Sadowska, Aneta Książek, Jan Nedergaard, Marek Konarzewski
    Conference:
    Annual Meeting of the Society for Experimental Biology, Goeteborg (rok: 2017, ), Wydawca: Society for Experimental Biology
    Data:
    konferencja 3-6 lipca
    Status:
    Published
  5. Energy management and locomotor activity in laboratory mice divergenty selected for basal metabolic rate
    Authors:
    Brzęk P., Selewestruk P., Gębczyński A., Nedergaard J., Konarzewski M.
    Conference:
    Annual Meeting of the Society for Experimental Biology, Sewilla (rok: 2019, ), Wydawca: Society for Experimental Biology
    Data:
    konferencja 2019
    Status:
    Published

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