Next generation in vitro experimental model of melanoma for pharmacological studies
2014/15/B/NZ7/00947
Keywords
Descriptors
- NZ7_14: Farmacja, farmakoterapia, farmakologia
- NZ7_16: Inne zagadnienia pokrewne
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Medyczny w Łodzi, Wydział Lekarski
Voivodeship: łódzkie
Principal investigator (from the host institution)
Number of co-investigators in the project: 6
Call
OPUS 8 – announced on 2014-09-15
- Amount awarded
- 1 398 040 PLN
- Project start date
- 2015-07-16
- Project end date
- 2019-07-15
- Project duration
- 48 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- Inkubator do howowli komórkowych. Cost: 34 000 PLN
- Platforma do rejestrowania obrazu komórek w czasie rzeczywistym zawierająca całkowicie zautomatyzowany mikroskop fluorescencyjny z oprogramowaniem. Cost: 480 000 PLN
- Wysokopojemny zasobnik dla azotu. Cost: 25 000 PLN
Information in the final report
Publication in academic press/journals (14)
-
Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro
- Authors:
- Osrodek M, Hartman ML, Czyz M
- Academic press:
- International Journal of Molecular Sciences (year: 2019, volume: 20, pages: E4203), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms20174203 – link to the publication
-
TYRP1 mRNA level is stable and MITF-M-independent in drug-naïve and vemurafenibresistant melanoma cells
- Authors:
- Hartman ML Czyz M
- Academic press:
- Archives of Dermatological Research (year: 2020, volume: 12, pages: 385-392), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s00403-019-01995-w – link to the publication
-
Role of miRNAs in Melanoma Metastasis
- Authors:
- Anna Gajos-Michniewicz, Małgorzata Czyż
- Academic press:
- Cancers (year: 2019, volume: 11, pages: E326), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cancers11030326 – link to the publication
-
17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.
- Authors:
- Mielczarek-Lewandowska A, Sztiller-Sikorska M, Osrodek M, Czyz M, Hartman ML
- Academic press:
- Apoptosis (year: 2019, volume: 24, pages: 596-611), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s10495-019-01542-y – link to the publication
-
Fibroblast Growth Factor Receptor Signaling in Skin Cancers
- Authors:
- Czyz M
- Academic press:
- Cells (year: 2019, volume: 8, pages: E540), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells8060540 – link to the publication
-
Plasticity of Drug-Naïve and Vemurafenib- or Trametinib-Resistant Melanoma Cells in Execution of Differentiation/Pigmentation Program
- Authors:
- Czyz M, Sztiller-Sikorska M, Gajos-Michniewicz A, Osrodek M, Hartman ML
- Academic press:
- Journal of Oncology (year: 2019, volume: 2019, pages: 1697913), Publisher: Hindawi
- Status:
- Published
- DOI:
- 10.1155/2019/1697913 – link to the publication
-
Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells
- Authors:
- Hartman ML, Sztiller-Sikorska M, Czyz M
- Academic press:
- Molecular Carcinogenesis (year: 2019, volume: 58, pages: 588-602), Publisher: Wiley
- Status:
- Published
- DOI:
- 10.1002/mc.22953 – link to the publication
-
miRNAs in Melanoma: Tumor Suppressors and Oncogenes with Prognostic Potential.
- Authors:
- Wozniak M, Mielczarek A, Czyz M.
- Academic press:
- Current Medicinal Chemistry (year: 2016, volume: 23 (28), pages: 3136-3153), Publisher: Bentham Science Publishers
- Status:
- Published
-
Dissecting Mechanisms of Melanoma Resistance to BRAF and MEK Inhibitors Revealed Genetic and Non-Genetic Patient- and Drug-Specific Alterations and Remarkable Phenotypic Plasticity
- Authors:
- Mariusz L. Hartman, Malgorzata Sztiller-Sikorska, Anna Gajos-Michniewicz and Malgorzata Czyz
- Academic press:
- Cells (year: 2020, volume: 9, pages: 142), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells9010142 – link to the publication
-
17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines
- Authors:
- Hartman ML, Rogut M, Mielczarek-Lewandowska A, Wozniak M, Czyz M
- Academic press:
- International Journal of Molecular Sciences (year: 2020, volume: 21, pages: 3749), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms21113749 – link to the publication
-
Inhibitors of HSP90 in melanoma
- Authors:
- Aleksandra Mielczarek-Lewandowska, Mariusz L. Hartman, Malgorzata Czyz
- Academic press:
- Apoptosis (year: 2020, volume: 25, pages: 46384), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s10495-019-01577-1 – link to the publication
-
HGF/c-MET Signaling in Melanocytes and Melanoma
- Authors:
- Czyz M
- Academic press:
- International Journal of Molecular Sciences (year: 2018, volume: 19 (12), pages: E3844), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms19123844 – link to the publication
-
Exogenous growth factors bFGF, EGF and HGF do not influence viability and phenotype of V600EBRAF melanoma cells and their response to vemurafenib and trametinib in vitro
- Authors:
- Zalesna I, Osrodek M, Hartman ML, Rozanski M, Sztiller-Sikorska M, Niewinna K, Nejc D, Czyz M
- Academic press:
- PlosOne (year: 2017, volume: 12 (8), pages: e0183498), Publisher: PLOS
- Status:
- Published
- DOI:
- 10.1371/journal.pone – link to the publication
-
Vemurafenib and trametinib reduce expression of CTGF and IL-8 in V600EBRAF melanoma cells
- Authors:
- Hartman ML, Rozanski M, Osrodek M, Zalesna I, Czyz M.
- Academic press:
- Laboratory Investigation (year: 2017, volume: 97(2), pages: 217-227), Publisher: Nature Publishing Group
- Status:
- Published
- DOI:
- 10.1038/labinvest.2016.140. – link to the publication