Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Next generation in vitro experimental model of melanoma for pharmacological studies

2014/15/B/NZ7/00947

Keywords:

melanoma genetic profile MAPK pathway inhibitors targeted tharapy vemurafenib trametinib

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Małgorzata Czyż 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 398 040 PLN

Project start date (Y-m-d): 2015-07-16

Project end date (Y-m-d): 2019-07-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Platforma do rejestrowania obrazu komórek w czasie rzeczywistym zawierająca całkowicie zautomatyzowany mikroskop fluorescencyjny z oprogramowaniem (480 000 PLN)
  2. Inkubator do howowli komórkowych (34 000 PLN)
  3. Wysokopojemny zasobnik dla azotu (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  1. Exogenous growth factors bFGF, EGF and HGF do not influence viability and phenotype of V600EBRAF melanoma cells and their response to vemurafenib and trametinib in vitro
    Authors:
    Zalesna I, Osrodek M, Hartman ML, Rozanski M, Sztiller-Sikorska M, Niewinna K, Nejc D, Czyz M
    Academic press:
    PlosOne (rok: 2017, tom: 12 (8), strony: e0183498), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone - link to the publication
  2. Inhibitors of HSP90 in melanoma
    Authors:
    Aleksandra Mielczarek-Lewandowska, Mariusz L. Hartman, Malgorzata Czyz
    Academic press:
    Apoptosis (rok: 2020, tom: 25, strony: 45654), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-019-01577-1 - link to the publication
  3. Plasticity of Drug-Naïve and Vemurafenib- or Trametinib-Resistant Melanoma Cells in Execution of Differentiation/Pigmentation Program
    Authors:
    Czyz M, Sztiller-Sikorska M, Gajos-Michniewicz A, Osrodek M, Hartman ML
    Academic press:
    Journal of Oncology (rok: 2019, tom: 2019, strony: 1697913), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/1697913 - link to the publication
  4. Role of miRNAs in Melanoma Metastasis
    Authors:
    Anna Gajos-Michniewicz, Małgorzata Czyż
    Academic press:
    Cancers (rok: 2019, tom: 11, strony: E326), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers11030326 - link to the publication
  5. miRNAs in Melanoma: Tumor Suppressors and Oncogenes with Prognostic Potential.
    Authors:
    Wozniak M, Mielczarek A, Czyz M.
    Academic press:
    Current Medicinal Chemistry (rok: 2016, tom: 23 (28), strony: 3136-3153), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    brak - link to the publication
  6. 17-Aminogeldanamycin selectively diminishes IRE1α-XBP1s pathway activity and cooperatively induces apoptosis with MEK1/2 and BRAFV600E inhibitors in melanoma cells of different genetic subtypes.
    Authors:
    Mielczarek-Lewandowska A, Sztiller-Sikorska M, Osrodek M, Czyz M, Hartman ML
    Academic press:
    Apoptosis (rok: 2019, tom: 24, strony: 596-611), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10495-019-01542-y - link to the publication
  7. Vemurafenib and trametinib reduce expression of CTGF and IL-8 in V600EBRAF melanoma cells
    Authors:
    Hartman ML, Rozanski M, Osrodek M, Zalesna I, Czyz M.
    Academic press:
    Laboratory Investigation (rok: 2017, tom: 97(2), strony: 217-227), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/labinvest.2016.140. - link to the publication
  8. Dissecting Mechanisms of Melanoma Resistance to BRAF and MEK Inhibitors Revealed Genetic and Non-Genetic Patient- and Drug-Specific Alterations and Remarkable Phenotypic Plasticity
    Authors:
    Mariusz L. Hartman, Malgorzata Sztiller-Sikorska, Anna Gajos-Michniewicz and Malgorzata Czyz
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 142), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9010142 - link to the publication
  9. Fibroblast Growth Factor Receptor Signaling in Skin Cancers
    Authors:
    Czyz M
    Academic press:
    Cells (rok: 2019, tom: 8, strony: E540), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8060540 - link to the publication
  10. HGF/c-MET Signaling in Melanocytes and Melanoma
    Authors:
    Czyz M
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19 (12), strony: E3844), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19123844 - link to the publication
  11. Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro
    Authors:
    Osrodek M, Hartman ML, Czyz M
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20, strony: E4203), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20174203 - link to the publication
  12. TYRP1 mRNA level is stable and MITF-M-independent in drug-naïve and vemurafenibresistant melanoma cells
    Authors:
    Hartman ML Czyz M
    Academic press:
    Archives of Dermatological Research (rok: 2020, tom: 12, strony: 385-392), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00403-019-01995-w - link to the publication
  13. Whole-exome sequencing reveals novel genetic variants associated with diverse phenotypes of melanoma cells
    Authors:
    Hartman ML, Sztiller-Sikorska M, Czyz M
    Academic press:
    Molecular Carcinogenesis (rok: 2019, tom: 58, strony: 588-602), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/mc.22953 - link to the publication
  14. 17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines
    Authors:
    Hartman ML, Rogut M, Mielczarek-Lewandowska A, Wozniak M, Czyz M
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: 3749), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21113749 - link to the publication

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