Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Structure-based modeling of ion channels activity considering influences of temperature, pressure, cell membrane fluctuations and other activating factors of a channel.

2014/15/N/NZ1/00889

Keywords:

activation gate dynamics gating mechanism simulation studies

Descriptors:

  • NZ1_3: Biophysics
  • ST1_18: Control theory and optimisation

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Politechnika Śląska, Wydział Chemiczny

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Agata Wawrzkiewicz-Jałowiecka 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 83 440 PLN

Project start date (Y-m-d): 2015-09-04

Project end date (Y-m-d): 2017-12-03

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. obliczeniowa stacja robocza (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. The temperature dependence of the BK channel activity – kinetics, thermodynamics, and long-range correlations.
    Authors:
    Agata Wawrzkiewicz-Jałowiecka, Beata Dworakowska, Zbigniew J. Grzywna
    Academic press:
    Biochimica et Biophysica Acta Biomembranes (rok: 2017, tom: 1859, strony: 1805-1814), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2017.05.013 - link to the publication
  2. Impact of geometry changes in the channel pore by the gating movements on the channel's conductance.
    Authors:
    Agata Wawrzkiewicz-Jałowiecka, Przemysław Borys, Zbigniew J. Grzywna
    Academic press:
    Biochimica et Biophysica Acta Biomembranes (rok: 2017, tom: 1859, strony: 446-458), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2017.01.002 - link to the publication
  3. Mechanosensitivity of the BK channels in human glioblastoma cells – kinetics and dynamical complexity.
    Authors:
    Agata Wawrzkiewicz-Jałowiecka, Paulina Trybek, Łukasz Machura, Beata Dworakowska, Zbigniew Grzywna
    Academic press:
    The Journal of Membrane Biology (rok: 2018, tom: 251, strony: 667–679), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00232-018-0044-9 - link to the publication
  4. The role of entropic potential in voltage activation and K+ transport through Kv 1.2 channels.
    Authors:
    Agata Wawrzkiewicz-Jałowiecka, Zbigniew Grzywna
    Academic press:
    The Journal of Chemical Physics (rok: 2018, tom: 148, strony: 115103), Wydawca: AIP Publishing
    Status:
    Published
    DOI:
    10.1063/1.5011298 - link to the publication

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