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Information on the principal investigator and host institution

Information of the project and the call

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Biotechnological research on accumulation of volatile fraction rich in active terpenoid compounds in in vitro cultures of Rhododendron tomentosum (Ledum palustre)

2014/15/N/NZ7/03027

Keywords:

Rhododendron tomentosum Ledum palustre in vitro cultures essential oil terpenoids micropropagation bioreactors high-performance thin layer chromatography gas chromatography anti-inflammatory activity

Descriptors:

  • NZ1_9: Biotechnology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Jesionek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 8 - announced on 2014-09-15

Amount awarded: 100 000 PLN

Project start date (Y-m-d): 2015-09-22

Project end date (Y-m-d): 2018-12-21

Project duration:: 39 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Automatyczny aparat zanurzeniowy CAMAG do wywoływania chromatogramów ze szklaną komorą.
  2. Komputer stacjonarny (3 500 PLN)
  3. Aparat Likens-Nickersona (kolba 1000 ml) (6 600 PLN)
  4. Trzystanowiskowa czasza grzejna Electrothermal EMEA z mieszadłem magnetycznym dla kolb o pojemności 1000 ml (6 500 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (3)
  1. Chemical variability of Rhododendron tomentosum (Ledum palustre) essential oils and their pro-apoptotic effect on lymphocytes and rheumatoid arthritis synoviocytes
    Authors:
    Anna Jesionek, Adam Kokotkiewicz, Anna Mikosik-Roczynska, Klaudia Ciesielska-Figlon, Piotr Luczkiewicz, Adam Bucinski, Agnieszka Daca, Jacek M. Witkowski, Ewa Bryl, Bozena Zabiegala, Maria Luczkiewicz
    Academic press:
    Fitoterapia (rok: 2019, tom: 139, strony: 104402), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.fitote.2019.104402 - link to the publication
  2. Validated HPTLC method for determination of ledol and alloaromadendrene in the essential oil fractions of Rhododendron tomentosum plants and in vitro cultures and bioautography for their activity screening
    Authors:
    Anna Jesionek, Loretta Poblocka-Olech, Bozena Zabiegala, Adam Bucinski, Miroslawa Krauze-Baranowska, Maria Luczkiewicz
    Academic press:
    Journal of Chromatography B (rok: 2018, tom: 1086, strony: 63-72), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2018.04.006 - link to the publication
  3. Elicitation strategies for the improvement of essential oil content in Rhododendron tomentosum (Ledum palustre) bioreactor-grown microshoots
    Authors:
    Anna Jesionek, Adam Kokotkiewicz, Aleksandra Krolicka, Bozena Zabiegala, Maria Luczkiewicz
    Academic press:
    Industrial Crops & Products (rok: 2018, tom: 123, strony: 461-469), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.indcrop.2018.07.013 - link to the publication
  4. From harvesting to extraction – effect of analytical procedures on the yield and chemical composition of Rhododendron tomentosum (Ledum palustre) essential oil
    Authors:
    Anna Jesionek, Bozena Zabiegala, Adam Bucinski, Maria Luczkiewicz
    Academic press:
    ACTA POLONIAE PHARMACEUTICA – DRUG RESEARCH (rok: 2019, tom: 76, strony: 83-92), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Published
    DOI:
    10.32383/appdr/78769 - link to the publication
  5. In vitro propagation of Rhododendron tomentosum – an endangered essential oil bearing plant from peatland
    Authors:
    Anna Jesionek, Adam Kokotkiewicz, Paulina Wlodarska, Natalia Filipowicz, Adam Bogdan, Renata Ochocka, Aleksandra Szreniawa-Sztajnert, Bozena Zabiegala, Adam Bucinski, Maria Luczkiewicz
    Academic press:
    ACTA BIOLOGICA CRACOVIENSIA Series Botanica (rok: 2016, tom: 58/2, strony: 29–43), Wydawca: Polish Academy of Sciences and Jagiellonian University, Cracow
    Status:
    Published
    DOI:
    10.1515/abcsb-2016-0019 - link to the publication
  6. Bioreactor shoot cultures of Rhododendron tomentosum (Ledum palustre) for a large-scale production of bioactive volatile compounds
    Authors:
    Anna Jesionek, Adam Kokotkiewicz, Paulina Wlodarska, Bozena Zabiegala, Adam Bucinski, Maria Luczkiewicz
    Academic press:
    Plant Cell Tiss Organ Cult (rok: 2017, tom: 131, strony: 51–64), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11240-017-1261-0 - link to the publication
  1. Quantitative analysis of ledol and alloaromadendrene by HPTLC method with densitometric detection in Rhododendron tomentosum (Ledum palustre) plants and in vitro cultures
    Authors:
    Jesionek Anna, Wlodarska Paulina, Bucinski Adam, Luczkiewicz Maria
    Conference:
    International Symposium for High Performance Thin Layer Chromatography (rok: 2017, ), Wydawca: Justus Liebig University Giessen
    Data:
    konferencja 4-8.07.2017
    Status:
    Published
  2. Biotechnological production of biologically active essential oil in Rhododendron tomentosum (Ledum palustre) microshoots in large-scale installations
    Authors:
    Jesionek Anna, Kokotkiewicz Adam, Wlodarska Paulina, Zabiegala Bozena, Luczkiewicz Maria
    Conference:
    6th International Congress of Aromatic and Medicinal Plants (rok: 2016, ), Wydawca: University of Coimbra
    Data:
    konferencja 29.05 - 01.06.2016
    Status:
    Published
    DOI:
    link to the publication
  3. Variation of ledol content in essential oil from in vivo and in vitro biomasses of Rhododendron tomentosum (Ledum palustre)
    Authors:
    Jesionek Anna, Wlodarska Paulina, Kokotkiewicz Adam, Zabiegala Bozena, Luczkiewicz Maria
    Conference:
    47th International Symposium on Essential Oils (rok: 2016, ), Wydawca: Université de Nice-Sophia Antipolis
    Data:
    konferencja 11-14.09.2016
    Status:
    Published

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