Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Efficacy, toxicity and immunogenicity of carriers made of bioengineered spider silk for targeted drug delivery

2014/15/B/NZ7/00903

Keywords:

targeted therapy bioengineered spider silk toxicity immunogenicity

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ1_9: Biotechnology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Hanna Dams-Kozłowska 

Number of co-investigators in the project: 8

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 695 130 PLN

Project start date (Y-m-d): 2015-09-04

Project end date (Y-m-d): 2020-09-03

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System oczyszczania wody (20 000 PLN)
  2. Wysokoprecyzyjna waga analityczna (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  • Articles in post-conference publications (2)
  1. Delivery of chemotherapeutics using spheres made of bioengineered spider silks derived from MaSp1 and MaSp2 proteins.
    Authors:
    Jastrzebska K, Florczak A, Kucharczyk K, Lin Y, Wang Q, Mackiewicz A, Kaplan DL, Dams-Kozlowska H.
    Academic press:
    Nanomedicine (Lond). (rok: 2018, tom: 13, strony: 439-454), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/nnm-2017-0276 - link to the publication
  2. Drug affinity and targeted delivery: double functionalization of silk spheres for controlled doxorubicin delivery into Her2‑positive cancer cells
    Authors:
    Kamil Kucharczyk, Anna Florczak, Tomasz Deptuch, Karolina Penderecka, Katarzyna Jastrzebska, Andrzej Mackiewicz, and Hanna Dams‑Kozlowska
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 56), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12951-020-00609-2 - link to the publication
  3. Functionalized bioengineered spider silk spheres improve nuclease resistance and activity of oligonucleotide therapeutics providing a strategy for cancer treatment
    Authors:
    Anna Karolina Kozlowska, Anna Florczak, Maciej Smialek, Ewelina Dondajewska, Andrzej Mackiewicz, Marcin Kortylewski, Hanna Dams-Kozlowska
    Academic press:
    Acta Biomaterialia (rok: 2017, tom: 59, strony: 221-233), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.actbio.2017.07.014 - link to the publication
  4. Cellular uptake, intracellular distribution and degradation of Her2-targeting silk nanospheres.
    Authors:
    Florczak A, Mackiewicz A, Dams-Kozlowska H.
    Academic press:
    International Journal of Nanomedicine (rok: 2019, tom: 14, strony: 6855-6865), Wydawca: DOVE MEDICAL PRESS LTD
    Status:
    Published
    DOI:
    10.2147/IJN.S217854 - link to the publication
  5. Silk Materials Functionalized via Genetic Engineering for Biomedical Applications
    Authors:
    Tomasz Deptuch and Hanna Dams-Kozlowska
    Academic press:
    Materials (rok: 2017, tom: 10, strony: 1417), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma10121417 - link to the publication
  6. The method of purifying bioengineered spider silk determines the silk sphere properties.
    Authors:
    Jastrzebska K, Felcyn E, Kozak M, Szybowicz M, Buchwald T, Pietralik Z, Jesionowski T, Mackiewicz A, Dams-Kozlowska H.
    Academic press:
    Scientific reports (rok: 2016, tom: 6, strony: 6:28106), Wydawca: London : Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep28106 - link to the publication
  7. Bioengineering the spider silk sequence to modify its affinity for drugs
    Authors:
    Kamil Kucharczyk, Marek Weiss, Katarzyna Jastrzebska, Magdalena Luczak, Arkadiusz Ptak, Maciej Kozak, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    International Journal of Nanomedicine (rok: 2018, tom: 13, strony: 4247-4261), Wydawca: DOVE MEDICAL PRESS LTD
    Status:
    Published
    DOI:
    10.2147/IJN.S168081 - link to the publication
  8. Hyperthermia treatment of cancer cells by the application of targeted silk/iron oxide composite spheres
    Authors:
    Kamil Kucharczyk, Katarzyna Kaczmarek, Arkadiusz Jozefczak, Mariusz Slachcinski, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    Materials Science and Engineering: C (rok: 2021, tom: 120, strony: 120:111654), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2020.111654 - link to the publication
  9. Optimization of spider silk sphere formation processing conditions to obtain carriers with controlled characteristics.
    Authors:
    Florczak A, Jastrzebska K, Bialas W, Mackiewicz A, Dams-Kozlowska H.
    Academic press:
    Journal of Biomedical Materials Research Part A (rok: 2018, tom: 106, strony: 3211-3221), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1002/jbm.a.36516. - link to the publication
  10. In Vivo Study of the Immune Response to the MS1-type Bioengineered Spider Silk Spheres
    Authors:
    Tomasz Deptuch, Karolina Penderecka, Hanna Dams-Kozlowska
    Academic press:
    NanoImpact (rok: 2021, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    nie - link to the publication
  11. Blending two bioengineered spider silks to develop cancer targeting spheres
    Authors:
    Anna Florczak, Katarzyna Jastrzebska, Andrzej Mackiewicz and Hanna Dams-Kozlowska
    Academic press:
    Journal of Materials Chemistry B (rok: 2017, tom: 5, strony: 3000-3011), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7tb00233e - link to the publication
  12. Composite spheres made of bioengineered spider silk and iron oxide nanoparticles for theranostics applications
    Authors:
    Kamil Kucharczyk, Jakub Dalibor Rybka, Michael Hilgendorff, Michal Krupinski, Mariusz Slachcinski, Andrzej Mackiewicz, Michael Giersig, Hanna Dams- Kozlowska
    Academic press:
    PlosOne (rok: 2019, tom: 14(7), strony: e0219790), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal. - link to the publication
  13. Functionalized Silk Spheres Selectively and Effectively Deliver a Cytotoxic Drug to Targeted Cancer Cells In Vivo.
    Authors:
    Anna Florczak, Tomasz Deptuch, Anna Lewandowska, Karolina Penderecka, Elzbieta Kramer, Andrzej Marszalek, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    Journal of Nanobiotechnology (rok: 2020, tom: 18, strony: 177), Wydawca: BMC Part of Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12951-020-00734-y - link to the publication
  14. MS1-type bioengineered spider silk nanoparticles do not exhibit toxicity in an in vivo mouse model
    Authors:
    Tomasz Deptuch, Anna Florczak, Anna Lewandowska, Ewa Leporowska, Karolina Penderecka, Andrzej Marszalek, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    Nanomedicine (Lond) (rok: 2021, tom: 16, strony: 1553-1565), Wydawca: Future Medicine Ltd
    Status:
    Published
    DOI:
    10.2217/nnm-2021-0029 - link to the publication
  15. Silk Particles as Carriers of Therapeutic Molecules for Cancer Treatment
    Authors:
    Anna Florczak , Inga Grzechowiak, Tomasz Deptuch, Kamil Kucharczyk, Alicja Kaminska, Hanna Dams-Kozlowska
    Academic press:
    Materials (rok: 2020, tom: 13, strony: 4946), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13214946 - link to the publication
  1. Bioengineered silk spheres for targeted drug delivery in Her2-positive breast cancer model.
    Authors:
    Anna Florczak, Tomasz Deptuch, Anna Lewandowska, Konstanty Korski, Andrzej Mackiewicz, Hanna Dams-Kozłowska.
    Conference:
    8th International Conference of Contemporary Oncology "Integrated oncology: genomics, immunotherapies, and molecular targets". (rok: 2016, ), Wydawca: Termedia sp. z o.o.
    Data:
    konferencja 16-18 March 2016.
    Status:
    Published
  2. Efficacy of carriers made of biotechnologically produced bioengineered silk for targeted drug delivery – in vivo study
    Authors:
    Anna Florczak, Tomasz Deptuch, Konstanty Korski, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Conference:
    Bio2016 – Expanding beyond the limits (rok: 2016, ), Wydawca: Polish Biochemical Society
    Data:
    konferencja 13-16 Sept
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy