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Identification of molecular events connected with development, growing and expansion of neuronal and mixed neuronal-glial tumors of central nervous system in children.

2014/15/B/NZ4/00744

Keywords

Descriptors

  • NZ2_2: Genomika, transkryptomika i epigenomika
  • NZ4_12: Inne zagadnienia pokrewne
  • NZ1_1: Biologia molekularna

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Magdalena Izabela Zakrzewska

Number of co-investigators in the project: 6

Call

OPUS 8 – announced on 2014-09-15

Amount awarded
1 173 500 PLN
Project start date
2015-07-16
Project end date
2019-07-15
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Termocykler. Cost: 50 000 PLN
  2. Wirówka laboratoryjna z chłodzeniem. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Sensitive detection of FGFR1 N546K mosaic mutation in patient with encephalocraniocutaneous lipomatosis and coexisted pilocytic astrocytoma

    Authors:
    Kordacka J, Zakrzewsk K, Gruszka R, Witusik-Perkowska M, Taha J, Sikorska B, Liberski PP, Zakrzewska M
    Academic press:
    American Journal of Medical Genetics: Part A (year: 2019, volume: Aug;179(8), pages: 1622-1627), Publisher: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/ajmg.a.61256. – link to the publication

  2. Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors

    Authors:
    Zakrzewska M, Gruszka R, Stawiski K, Fendler W, Kordacka J, Grajkowska W, Daszkiewicz P, Liberski PP, Zakrzewski K
    Academic press:
    BMC Cancer (year: 2019, volume: Jun 6;19(1), pages: 544), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12885-019-5739-5 – link to the publication

  3. Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors

    Authors:
    Rivera B, Gayden T, Carrot-Zhang J, Nadaf J, Boshari T, Faury D, Zeinieh M, Blanc R, Burk DL, Fahiminiya S, Bareke E, Schüller U, Monoranu CM, Sträter R, Kerl K, Niederstadt T, Kurlemann G, Ellezam B, Michalak Z, Thom M, Lockhart PJ, Leventer RJ, Ohm M, MacGregor D, Jones D, Karamchandani J, Greenwood CM, Berghuis AM, Bens S, Siebert R, Zakrzewska M, Liberski PP, Zakrzewski K, Sisodiya SM, Paulus W, Albrecht S, Hasselblatt M, Jabado N, Foulkes WD, Majewski J
    Academic press:
    Acta Neuropathologica (year: 2016, volume: 131(6), pages: 847-863), Publisher: Springer International Publishing AG. Part of Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00401-016-1549-x – link to the publication

  4. The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors

    Authors:
    Gruszka R, Zakrzewska M
    Academic press:
    Int J Mol Sci. (year: 2018, volume: 19(3), pages: 879), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19030879. – link to the publication

Articles in post-conference publications (3)

  1. BRAF and H3F3A genes mutations in neuronal and mixed neuronal-glial tumours of childhood.

    Authors:
    Joanna Kordacka, Magdalena Zakrzewska
    Conference:
    Juvenes Pro Medicina (year: 2017, pages: 149), Publisher: Students' Scientific Association of the Medical University of Lodz
    Date:
    conference 19-20 maja
    Status:
    Published

  2. An eight year-old with encephalocraniocutaneous lipomatosis and pilocytic astrocytoma - a case study with genetic analysis

    Authors:
    Kordacka J, Zakrzewska M
    Conference:
    Juvenes Pro Medicina (year: 2018, pages: 150), Publisher: Students' Scientific Association of the Medical University of Lodz
    Date:
    conference 25-26 maja
    Status:
    Published

  3. Comparative Analysis of miRNA Expression in Pediatric Neuronal and Mixed Neuronal-Glial Tumors

    Authors:
    M. Zakrzewska, W. Fendler, K. Stawiski, R. Gruszka, K. Zakrzewski, P.P. Liberski
    Conference:
    49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP) (year: 2017, pages: S318 of S518), Publisher: WILEY Pediatric Blood & Cancer
    Date:
    conference 12–15 października
    Status:
    Published

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