Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Identification of molecular events connected with development, growing and expansion of neuronal and mixed neuronal-glial tumors of central nervous system in children.

2014/15/B/NZ4/00744

Keywords:

central nervous system epigenetics expression methylation miRNA neuronal and mixed neuronal-glial tumors

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ4_12: Other related subjects
  • NZ1_1: Molecular biology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Zakrzewska 

Number of co-investigators in the project: 6

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 1 173 500 PLN

Project start date (Y-m-d): 2015-07-16

Project end date (Y-m-d): 2019-07-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termocykler (50 000 PLN)
  2. Wirówka laboratoryjna z chłodzeniem (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  1. Expression-based decision tree model reveals distinct microRNA expression pattern in pediatric neuronal and mixed neuronal-glial tumors
    Authors:
    Zakrzewska M, Gruszka R, Stawiski K, Fendler W, Kordacka J, Grajkowska W, Daszkiewicz P, Liberski PP, Zakrzewski K
    Academic press:
    BMC Cancer (rok: 2019, tom: Jun 6;19(1), strony: 544), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12885-019-5739-5 - link to the publication
  2. Germline and somatic FGFR1 abnormalities in dysembryoplastic neuroepithelial tumors
    Authors:
    Rivera B, Gayden T, Carrot-Zhang J, Nadaf J, Boshari T, Faury D, Zeinieh M, Blanc R, Burk DL, Fahiminiya S, Bareke E, Schüller U, Monoranu CM, Sträter R, Kerl K, Niederstadt T, Kurlemann G, Ellezam B, Michalak Z, Thom M, Lockhart PJ, Leventer RJ, Ohm M, MacGregor D, Jones D, Karamchandani J, Greenwood CM, Berghuis AM, Bens S, Siebert R, Zakrzewska M, Liberski PP, Zakrzewski K, Sisodiya SM, Paulus W, Albrecht S, Hasselblatt M, Jabado N, Foulkes WD, Majewski J
    Academic press:
    Acta Neuropathologica (rok: 2016, tom: 131(6), strony: 847-863), Wydawca: Springer International Publishing AG. Part of Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00401-016-1549-x - link to the publication
  3. Sensitive detection of FGFR1 N546K mosaic mutation in patient with encephalocraniocutaneous lipomatosis and coexisted pilocytic astrocytoma
    Authors:
    Kordacka J, Zakrzewsk K, Gruszka R, Witusik-Perkowska M, Taha J, Sikorska B, Liberski PP, Zakrzewska M
    Academic press:
    American Journal of Medical Genetics: Part A (rok: 2019, tom: Aug;179(8), strony: 1622-1627), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/ajmg.a.61256. - link to the publication
  4. The Oncogenic Relevance of miR-17-92 Cluster and Its Paralogous miR-106b-25 and miR-106a-363 Clusters in Brain Tumors
    Authors:
    Gruszka R, Zakrzewska M
    Academic press:
    Int J Mol Sci. (rok: 2018, tom: 19(3), strony: 879), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19030879. - link to the publication
  1. Comparative Analysis of miRNA Expression in Pediatric Neuronal and Mixed Neuronal-Glial Tumors
    Authors:
    M. Zakrzewska, W. Fendler, K. Stawiski, R. Gruszka, K. Zakrzewski, P.P. Liberski
    Conference:
    49th CONGRESS OF THE INTERNATIONAL SOCIETY OF PAEDIATRIC ONCOLOGY (SIOP) (rok: 2017, ), Wydawca: WILEY Pediatric Blood & Cancer
    Data:
    konferencja 12–15 października
    Status:
    Published
  2. An eight year-old with encephalocraniocutaneous lipomatosis and pilocytic astrocytoma - a case study with genetic analysis
    Authors:
    Kordacka J, Zakrzewska M
    Conference:
    Juvenes Pro Medicina (rok: 2018, ), Wydawca: Students' Scientific Association of the Medical University of Lodz
    Data:
    konferencja 25-26 maja
    Status:
    Published
  3. BRAF and H3F3A genes mutations in neuronal and mixed neuronal-glial tumours of childhood.
    Authors:
    Joanna Kordacka, Magdalena Zakrzewska
    Conference:
    Juvenes Pro Medicina (rok: 2017, ), Wydawca: Students' Scientific Association of the Medical University of Lodz
    Data:
    konferencja 19-20 maja
    Status:
    Published

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