Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Regulation of mechanisms of iron and heme acquisition and virulence in Porphyromonas gingivalis with involvement of PgFur protein and small RNAs

2014/15/B/NZ6/01723

Keywords:

Porphyromonas gingivalis periodontitis Fur gene expression small RNA iron heme virulence

Descriptors:

  • NZ6_4: Bacteriology
  • NZ5_3: Pathogenesis of human diseases
  • NZ1_10: Microbiology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Teresa Olczak 

Number of co-investigators in the project: 7

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 855 640 PLN

Project start date (Y-m-d): 2015-07-24

Project end date (Y-m-d): 2018-07-23

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 (30 000 PLN)
  2. Termocykler do analiz w czasie rzeczywistym (120 000 PLN)
  3. Wirówka do zwirowywania płytek 96-dołkowych do reakcji PCR w czasie rzeczywistym (3 360 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. PgRsp is a novel redox-sensing transcription regulator essential for Porphyromonas gingivalis virulence
    Authors:
    Śmiga M, Olczak T
    Academic press:
    Microorganisms (rok: 2019, tom: 7, strony: 623), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/microorganisms7120623 - link to the publication
  2. PgFur participates differentially in expression of virulence factors in more virulent A7436 and less virulent ATCC 33277 Porphyromonas gingivalis strains
    Authors:
    Śmiga M, Stępień P, Olczak M, Olczak T
    Academic press:
    BMC Microbiology (rok: 2019, tom: 19, strony: 127), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1186/s12866-019-1511-x - link to the publication
  3. Porphyromonas gingivalis PgFur is a member of a novel Fur subfamily with non-canonical function
    Authors:
    Śmiga M, Bielecki M, Olczak M, Olczak T
    Academic press:
    Frontiers in Cellular and Infection Microbiology (rok: 2019, tom: 9, strony: 233), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcimb.2019.00233 - link to the publication
  4. Haem acquisition mechanisms of Porphyromonas gingivalis - strategies used in polymicrobial community in a haem-limited host environment.
    Authors:
    Samlley JW, Olczak T
    Academic press:
    Molecular Oral Microbiology (rok: 2017, tom: 32, strony: 45314), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/omi.12149 - link to the publication

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