Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Evaluation of an influence of interaction between clopidogrel and statins possessing different pharmacokinetic properties on therapeutic effect of clopidogrel in patients undergoing coronary angiography/angioplasty

2014/15/B/NZ7/00869

Keywords:

pharmacokinetics platelet aggregation pharmacogenetics atorvastatin rosuvastatin

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Karaźniewicz-Łada 

Number of co-investigators in the project: 5

Call: OPUS 8 - announced on 2014-09-15

Amount awarded: 472 500 PLN

Project start date (Y-m-d): 2015-08-11

Project end date (Y-m-d): 2019-08-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. aparat Multiplate do oceny funkcji płytek (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. Influence of genetic co-factors on the population pharmacokinetic model for clopidogrel and its active thiol metabolite
    Authors:
    Dorota Danielak, Marta Karaźniewicz-Łada, Anna Komosa, Paweł Burchardt, Maciej Lesiak, Łukasz Kruszyna, Agnieszka Graczyk-Szuster, Franciszek Główka
    Academic press:
    European Journal of Clinical Pharmacology (rok: 2017, tom: 73, strony: 1623-1632), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00228-017-2334-z - link to the publication
  2. Determinants of high on-treatment platelet reactivity and agreement between VerifyNow and Multiplate assays
    Authors:
    Dorota Danielak, Anna Komosa, Aleksandra Tomczak, Agnieszka Graczyk-Szuster, Maciej Lesiak, Franciszek Główka, Marta Karaźniewicz-Łada
    Academic press:
    Scandinavian Journal of Clinical and Laboratory Investigation (rok: 2017, tom: 77, strony: 190-198), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/00365513.2017.1286686 - link to the publication
  3. Development and validation of an RP-HPLC method for determination of atorvastatin and its hydroxyl metabolites in human plasma
    Authors:
    Dagmara Sowińska, Alicja Pogorzelska, Marlena Rakicka, Justyna Sznura, Justyna Janowska, Patrycja Gorzycka, Mateusz Malak, Marta Karaźniewicz-Łada
    Academic press:
    Current Pharmaceutical Analysis (rok: 2020, tom: 16, strony: 238-245), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1573412914666180912110154 - link to the publication
  4. INFLUENCE OF STATIN TREATMENT ON PHARMACOKINETICS AND PHARMACODYNAMICS OF CLOPIDOGREL AND ITS METABOLITES IN PATIENTS AFTER CORONARY ANGIOGRAPHY/ANGIOPLASTY
    Authors:
    Marta Karaźniewicz-Łada, Janusz Rzeźniczak, Franciszek Główka, Adriana Gumienna, Filip Dolatowski, Marek Słomczyński, Paweł Burchardt
    Academic press:
    Biomedicine&Pharmacotherapy (rok: 2019, tom: 116, strony: 108991), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2019.108991 - link to the publication
  5. Genetic and non-genetic determinants of the pharmacological activity of statins
    Authors:
    Marta Karaźniewicz-Łada, Anna Główka, Jakub Mikołajewski, Juliusz Przysławski
    Academic press:
    Current Drug Metabolism (rok: 2016, tom: 17, strony: 877-896), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1389200217666160919104241 - link to the publication
  6. IMPACT OF GENETIC VARIANTS OF SELECTED CYTOCHROME P450 ISOENZYMES ON PHARMACOKINETICS AND PHARMACODYNAMICS OF CLOPIDOGREL IN PATIENTS CO-TREATED WITH ATORVASTATIN OR ROSUVASTATIN
    Authors:
    Marta Karaźniewicz-Łada, Dagmara Krzyżańska, Dorota Danielak, Janusz Rzeźniczak, Franciszek Główka, Marek Słomczyński, Paweł Burchardt
    Academic press:
    European Journal of Clinical Pharmacology (rok: 2020, tom: 76, strony: 419-430), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00228-019-02822-x - link to the publication
  1. Simultaneous analysis of atorvastatin and its two active metabolites in human plasma by UPLC-MS/MS method
    Authors:
    M. Karaźniewicz-Łada, K. Bąba, F. Główka
    Conference:
    2nd Summer School on Oral Dosage Forms: Fundamentals, Challenges and Future Opportunities, ORBIS Workshop on Dosage Forms and Drug Delivery Systems (rok: 2019, ), Wydawca: University of Helsinki
    Data:
    konferencja 18-20.09.2019
    Status:
    Published
  2. Influence of statin treatment on pharmacokinetics and pharmacodynamics of clopidogrel and its metabolites in patients undergoing coronary angiography/angioplasty
    Authors:
    M. Karaźniewicz-Łada, B. Burchardt, D. Danielak, M. Słomczyński, J. Rzeźniczak, A. Gumienna, F. Główka
    Conference:
    XXVIII International Symposium on Pharmaceutical and Biomedical Analysis (PBA 2017) (rok: 2017, ), Wydawca: International PBA Scientific Committee
    Data:
    konferencja 2-5.07.2017
    Status:
    Published
  1. Zastosowanie metody UHPLC-MS/MS do badań farmakokinetycznych klopidogrelu i jego metabolitów w osoczu pacjentów poddawanych angiografii/angioplastyce tętnic wieńcowych
    Authors:
    Marta Karaźniewicz-Łada, Alicja Dobrowolska, Adriana Gumienna.
    Book:
    Współczesne problemy medycyny - przegląd zagadnień. (rok: 2018, tom: b.d., strony: 130-141), Wydawca: Wydaw. Nauk. TYGIEL, 2018
    Status:
    Published

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