Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The molecular mechanism of activity of alphaherpesvirus-encoded key immune evasion proteins

2014/14/E/NZ6/00164

Keywords:

alphaherpesvirus immune evasion BHV-1 MHC class I transport of antigenic peptides endocytosis tetherin

Descriptors:

  • NZ6_5: Virology
  • NZ1_1: Molecular biology
  • NZ1_10: Microbiology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Andrea Lipińska 

Number of co-investigators in the project: 9

Call: SONATA BIS 4 - announced on 2014-06-16

Amount awarded: 1 870 760 PLN

Project start date (Y-m-d): 2015-05-05

Project end date (Y-m-d): 2021-01-04

Project duration:: 68 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Nastołowy dwu-laserowy cytometr przepływowy z zestawem komputerowym (250 000 PLN)
  2. Zestaw komputerowy dużej mocy obliczeniowej-serwer (15 000 PLN)
  3. System do obrazowania i dokumentacji kwasów nukleinowych (50 000 PLN)
  4. Wirówka na duże objętości z chłodzeniem.
  5. Wirówka z chłodzeniem (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Investigation of the Effects of Primary Structure Modifications within the RRE Motif on the Conformation of Synthetic Bovine Herpesvirus 1‐Encoded UL49.5 Protein Fragments
    Authors:
    Karska N, Graul M, Sikorska E, Ślusarz MJ, Zhukov I, Kasprzykowski F, Kubiś A, Lipińska AD, Rodziewicz-Motowidło S.
    Academic press:
    Chemistry and Biodiversity (rok: 2021, tom: 18(2), strony: e2000883), Wydawca: Wiley-VHCA AG, Zurich, Switzerland
    Status:
    Published
    DOI:
    10.1002/cbdv.202000883 - link to the publication
  2. Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics
    Authors:
    Karska N, Graul M, Sikorska E, Zhukov I, Ślusarz MJ, Kasprzykowski F, Lipińska AD, Rodziewicz-Motowidło S
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Biomembranes (rok: 2019, tom: 1861(5), strony: 926-938), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2019.02.005 - link to the publication
  3. Fluorescent TAP as a platform for virus-induced degradation of the antigenic peptide transporter
    Authors:
    Wąchalska M, Graul M, Praest P, Luteijn RD, Babnis AW, Wiertz EJHJ, Bieńkowska-Szewczyk K, Lipińska AD
    Academic press:
    Cells (rok: 2019, tom: 8, strony: E1590), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8121590 - link to the publication
  4. Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking
    Authors:
    Graul M, Kisielnicka E, Rychłowski M, Verweij MC, Tobler K, Ackermann M, Wiertz EJHJ, Bieńkowska-Szewczyk K, Lipińska AD
    Academic press:
    Journal of General Virology (rok: 2019, tom: 100(3), strony: 497-510), Wydawca: Microbiology Society
    Status:
    Published
    DOI:
    10.1099/jgv.0.001224 - link to the publication