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Role of the complement system in tumorigenesis and therapeutic approaches.

2014/14/E/NZ6/00182

Keywords

Descriptors

  • NZ6_1: Odporność swoista i nieswoista
  • NZ5_3: Patogeneza chorób człowieka
  • NZ6_2: Immunologia kliniczna

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Marcin Okrój

Number of co-investigators in the project: 3

Call

SONATA BIS 4 – announced on 2014-06-16

Amount awarded
1 945 000 PLN
Project start date
2015-07-01
Project end date
2022-06-30
Project duration
84 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. inkubator do hodowli komórek in vitro. Cost: 20 000 PLN
  2. komora laminarna.
  3. komputer (2 pcs). Cost: 12 000 PLN
  4. lodówka laboratoryjna. Cost: 1 500 PLN
  5. płuczka do testów immunoenzymatycznych.
  6. software (2 pcs). Cost: 20 000 PLN
  7. termoblok - wytrząsarka stołowa (2 pcs). Cost: 10 000 PLN
  8. wielodetekcyjny czytnik płytek z przystawką do obrazowania komórek. Cost: 250 000 PLN
  9. wytrząsarka orbitalna do inkuatora CO2.
  10. zamrażarka - 80 C. Cost: 32 000 PLN
  11. zestaw pipet automatycznych, wielostopniowych. Cost: 3 000 PLN
  12. zestaw pipet jedno i wielokanałowych (3 pcs). Cost: 10 500 PLN

Information in the final report

Publication in academic press/journals (13)

  1. Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis.

    Authors:
    Blom AM, Corvillo F, Magda M, Stasiłojć G, Nozal P, Pérez-Valdivia MÁ, Cabello-Chaves V, Rodríguez de Córdoba S, López-Trascasa M, Okrój M
    Academic press:
    Journal of Clinical Immunology (year: 2016, volume: 36, pages: 517-527), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10875-016-0290-5. – link to the publication

  2. Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis.

    Authors:
    Okrój M, Johansson M, Saxne T, Blom AM, Hesselstrand R.
    Academic press:
    Arthritis Research and Therapy (year: 2016, volume: 18, pages: 267), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13075-016-1168-x – link to the publication

  3. The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis

    Authors:
    Struglics A *, Okroj M * , Swärd P, Frobell R, Saxne T, Lohmander S, Blom AM. * - shared 1st authorship
    Academic press:
    Arthritis Research and Therapy (year: 2016, volume: 18, pages: 223), Publisher: PubMed Central
    Status:
    Published
    DOI:
    10.1186/s13075-016-1123-x – link to the publication

  4. Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus.

    Authors:
    Martin M, Smoląg KI, Björk A, Gullstrand B, Okrój M, Leffler J, Jönsen A, Bengtsson AA, Blom AM
    Academic press:
    Arthritis Research and Therapy (year: 2017, volume: 19, pages: 266), Publisher: Biomed Central Ltd.
    Status:
    Published
    DOI:
    10.1186/s13075-017-1470-2. – link to the publication

  5. Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics.

    Authors:
    Felberg A, Urban A, Borowska A, Stasiłojć G, Taszner M, Hellmann A, Blom AM, Okrój M.
    Academic press:
    Cancer Immunology Immunotherapy (year: 2019, volume: 68, pages: 587-598), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-019-02304-0 – link to the publication

  6. Measuring plasma C4D to monitor immune complexes in lupus nephritis

    Authors:
    Kraaij T, Nilsson SC, van Kooten C, Okrój M, Blom AM, Teng YO.
    Academic press:
    Lupus Science & Medicine (year: 2019, volume: 6, pages: e000326), Publisher: BMJ Journals
    Status:
    Published
    DOI:
    10.1136/lupus-2019-000326 – link to the publication

  7. New perspectives on complement mediated immunotherapy.

    Authors:
    Stasiłojć G, Österborg A, Blom AM, Okrój M.
    Academic press:
    Cancer Treatment Reviews (year: 2016, volume: 45, pages: 68-75), Publisher: Elsevier / Science Direct
    Status:
    Published
    DOI:
    10.1016/j.ctrv.2016.02.009 – link to the publication

  8. Calcein release assay as a method for monitoring serum complement activity during monoclonal antibody therapy in patients with B-cell malignancies.

    Authors:
    Stasiłojć G, Felberg A, Urban A, Kowalska D, Ma S, Blom AM, Lundin J, Österborg A, Okrój M
    Academic press:
    Journal of Immunological Methods (year: 2020, volume: 476, pages: 112675), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jim.2019.112675 – link to the publication

  9. Monitoring of the Complement System Status in Patients With B-Cell Malignancies Treated With Rituximab

    Authors:
    Anna Felberg, Michał Taszner, Aleksandra Urban, Alan Majeranowski, Kinga Jaskuła, Aleksandra Jurkiewicz, Grzegorz Stasiłojć, Anna M Blom, Jan M Zaucha, Marcin Okrój
    Academic press:
    Frontiers in Immunology (year: 2020, volume: 11, pages: 584509), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.584509 – link to the publication

  10. Complement Activation as a Helping Hand for Inflammophilic Pathogens and Cancer.

    Authors:
    Okrój M, Potempa J
    Academic press:
    Frontiers in Immunology (year: 2019, volume: 9, pages: 3125), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.03125 – link to the publication

  11. Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.

    Authors:
    Michels MAHM, van de Kar NCAJ, Okrój M, Blom AM, van Kraaij SAW, Volokhina EB1, van den Heuvel LPWJ
    Academic press:
    Frontiers in Immunology (year: 2018, volume: 9, pages: 612), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.00612 – link to the publication

  12. Parameters critical for the effector mechanism of anti-CD20 antibodies revisited.

    Authors:
    Stasiłojć G, Felberg A, Okrój M.
    Academic press:
    British Journal of Haematology (year: 2018, volume: 180, pages: 777-779), Publisher: John Wiley at Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/bjh.15130 – link to the publication

  13. Complement C4d-specific antibodies for the diagnosis of lung cancer.

    Authors:
    Ajona D, Okrój M, Pajares MJ, Agorreta J, Lozano MD, Zulueta JJ, Verri C, Roz L, Sozzi G, Pastorino U, Massion PP, Montuenga LM, Blom AM, Pio R.
    Academic press:
    Oncotarget (year: 2018, volume: 9, pages: 6346-6355), Publisher: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.23690 – link to the publication

Articles in post-conference publications (4)

  1. Changes in serum complement activity during anti-CD20 and anti-CD52 monoclonal antibody therapy in patients with chronic lymphocytic leukemia (CLL).

    Authors:
    Grzegorz Stasiłojć, Anna Felberg, Michał Taszner, Aleksandra Urban, Shuo Ma, Anna Blom, Jeanette Lundin, Anders Österborg, Marcin Okrój
    Conference:
    17th European Meeting on Complement in Human Diseases, EMCHD 2019, Madrid, (Spain) (year: 2019, pages: 415), Publisher: Elsevier/Molecular Immunology
    Date:
    conference September 14-17, 2019
    Status:
    Published

  2. Mutations resulting in formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics

    Authors:
    Anna Felberg-Miętka, Aleksandra Urban, Anna Borowska, Grzegorz Stasiłojć, Michał Taszner, Andrzej Hellmann, Anna M. Blom, Marcin Okrój
    Conference:
    17th European Meeting on Complement in Human Diseases, EMCHD 2019, Madrid, (Spain), (year: 2019, pages: 414), Publisher: Elsevier/Molecular Immunology
    Date:
    conference September 14-17, 2019
    Status:
    Published

  3. Acquisition of complement-dependent cytotoxicity by type II anti-CD20 therapeutic antibody obinutuzumab.

    Authors:
    Alicja Kuźniewska, Alan Majeranowski, Daria Kowalska, Aleksandra Urban, Sara Henry, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (ICS) (year: 2021, pages: 122-123), Publisher: Elsevier / Molecular Immunology
    Date:
    conference 6-10 grudnia 2021
    Status:
    Published

  4. Assessment of the role of factor I in non-small cell lung cancer (NSCLC) progression.

    Authors:
    Anna Felberg-Miętka, Aleksandra Urban, Alicja Kuźniewska, Grzegorz Stasiłojć, Michał Bieńkowski, Ruben Pio, Luis Montuenga, Robbert Spaapen, Anna Blom, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (year: 2021, pages: 129), Publisher: Elsevier / Molecular Immunology
    Date:
    conference 6-10 grudnia
    Status:
    Published
    DOI:
    link to the publication

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Graphic design and implementation: Jakub Piotrowski