Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of the complement system in tumorigenesis and therapeutic approaches.

2014/14/E/NZ6/00182

Keywords:

complement system monoclonal antibodies cancer

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ5_3: Pathogenesis of human diseases
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Okrój 

Number of co-investigators in the project: 3

Call: SONATA BIS 4 - announced on 2014-06-16

Amount awarded: 1 945 000 PLN

Project start date (Y-m-d): 2015-07-01

Project end date (Y-m-d): 2022-06-30

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. inkubator do hodowli komórek in vitro (20 000 PLN)
  2. lodówka laboratoryjna (1 500 PLN)
  3. płuczka do testów immunoenzymatycznych.
  4. wytrząsarka orbitalna do inkuatora CO2.
  5. zamrażarka - 80 C (32 000 PLN)
  6. zestaw pipet automatycznych, wielostopniowych (3 000 PLN)
  7. software (2 szt.) (20 000 PLN)
  8. wielodetekcyjny czytnik płytek z przystawką do obrazowania komórek (250 000 PLN)
  9. komora laminarna.
  10. zestaw pipet jedno i wielokanałowych (3 szt.) (10 500 PLN)
  11. termoblok - wytrząsarka stołowa (2 szt.) (10 000 PLN)
  12. komputer (2 szt.) (12 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (4)
  1. Measuring plasma C4D to monitor immune complexes in lupus nephritis
    Authors:
    Kraaij T, Nilsson SC, van Kooten C, Okrój M, Blom AM, Teng YO.
    Academic press:
    Lupus Science & Medicine (rok: 2019, tom: 6, strony: e000326), Wydawca: BMJ Journals
    Status:
    Published
    DOI:
    10.1136/lupus-2019-000326 - link to the publication
  2. New perspectives on complement mediated immunotherapy.
    Authors:
    Stasiłojć G, Österborg A, Blom AM, Okrój M.
    Academic press:
    Cancer Treatment Reviews (rok: 2016, tom: 45, strony: 68-75), Wydawca: Elsevier / Science Direct
    Status:
    Published
    DOI:
    10.1016/j.ctrv.2016.02.009 - link to the publication
  3. Parameters critical for the effector mechanism of anti-CD20 antibodies revisited.
    Authors:
    Stasiłojć G, Felberg A, Okrój M.
    Academic press:
    British Journal of Haematology (rok: 2018, tom: 180, strony: 777-779), Wydawca: John Wiley at Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/bjh.15130 - link to the publication
  4. Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis.
    Authors:
    Blom AM, Corvillo F, Magda M, Stasiłojć G, Nozal P, Pérez-Valdivia MÁ, Cabello-Chaves V, Rodríguez de Córdoba S, López-Trascasa M, Okrój M
    Academic press:
    Journal of Clinical Immunology (rok: 2016, tom: 36, strony: 517-527), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10875-016-0290-5. - link to the publication
  5. Elevated expression of complement factor I in lung cancer cells associates with shorter survival - potentially via non-canonical mechanism.
    Authors:
    Anna Felberg, Michał Bieńkowski, Tomasz Stokowy, Kamil Myszczyński, Frida Mohlin, Alicja Kuźniewska, Ilse Jongerius, Robbert Spaapen, Miguel Mesa-Guzman, Luis M. Montuenga, Anna M. Blom, Ruben Pio, Marcin Okrój
    Academic press:
    Cancer Communications , Wydawca: Wiley and Sons
    Status:
    Submitted
    DOI:
    brak - link to the publication
  6. Complement Activation as a Helping Hand for Inflammophilic Pathogens and Cancer.
    Authors:
    Okrój M, Potempa J
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 9, strony: 3125), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.03125 - link to the publication
  7. Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics.
    Authors:
    Felberg A, Urban A, Borowska A, Stasiłojć G, Taszner M, Hellmann A, Blom AM, Okrój M.
    Academic press:
    Cancer Immunology Immunotherapy (rok: 2019, tom: 68, strony: 587-598), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-019-02304-0 - link to the publication
  8. Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus.
    Authors:
    Martin M, Smoląg KI, Björk A, Gullstrand B, Okrój M, Leffler J, Jönsen A, Bengtsson AA, Blom AM
    Academic press:
    Arthritis Research and Therapy (rok: 2017, tom: 19, strony: 266), Wydawca: Biomed Central Ltd.
    Status:
    Published
    DOI:
    10.1186/s13075-017-1470-2. - link to the publication
  9. The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis
    Authors:
    Struglics A *, Okroj M * , Swärd P, Frobell R, Saxne T, Lohmander S, Blom AM. * - shared 1st authorship
    Academic press:
    Arthritis Research and Therapy (rok: 2016, tom: 18, strony: 223), Wydawca: PubMed Central
    Status:
    Published
    DOI:
    10.1186/s13075-016-1123-x - link to the publication
  10. Complement C4d-specific antibodies for the diagnosis of lung cancer.
    Authors:
    Ajona D, Okrój M, Pajares MJ, Agorreta J, Lozano MD, Zulueta JJ, Verri C, Roz L, Sozzi G, Pastorino U, Massion PP, Montuenga LM, Blom AM, Pio R.
    Academic press:
    Oncotarget (rok: 2018, tom: 9, strony: 6346-6355), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.23690 - link to the publication
  11. Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis.
    Authors:
    Okrój M, Johansson M, Saxne T, Blom AM, Hesselstrand R.
    Academic press:
    Arthritis Research and Therapy (rok: 2016, tom: 18, strony: 267), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13075-016-1168-x - link to the publication
  12. Calcein release assay as a method for monitoring serum complement activity during monoclonal antibody therapy in patients with B-cell malignancies.
    Authors:
    Stasiłojć G, Felberg A, Urban A, Kowalska D, Ma S, Blom AM, Lundin J, Österborg A, Okrój M
    Academic press:
    Journal of Immunological Methods (rok: 2020, tom: 476, strony: 112675), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jim.2019.112675 - link to the publication
  13. Monitoring of the Complement System Status in Patients With B-Cell Malignancies Treated With Rituximab
    Authors:
    Anna Felberg, Michał Taszner, Aleksandra Urban, Alan Majeranowski, Kinga Jaskuła, Aleksandra Jurkiewicz, Grzegorz Stasiłojć, Anna M Blom, Jan M Zaucha, Marcin Okrój
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 11, strony: 584509), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.584509 - link to the publication
  14. Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.
    Authors:
    Michels MAHM, van de Kar NCAJ, Okrój M, Blom AM, van Kraaij SAW, Volokhina EB1, van den Heuvel LPWJ
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: 612), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.00612 - link to the publication
  1. Changes in serum complement activity during anti-CD20 and anti-CD52 monoclonal antibody therapy in patients with chronic lymphocytic leukemia (CLL).
    Authors:
    Grzegorz Stasiłojć, Anna Felberg, Michał Taszner, Aleksandra Urban, Shuo Ma, Anna Blom, Jeanette Lundin, Anders Österborg, Marcin Okrój
    Conference:
    17th European Meeting on Complement in Human Diseases, EMCHD 2019, Madrid, (Spain) (rok: 2019, ), Wydawca: Elsevier/Molecular Immunology
    Data:
    konferencja September 14-17, 2019
    Status:
    Published
  2. Acquisition of complement-dependent cytotoxicity by type II anti-CD20 therapeutic antibody obinutuzumab.
    Authors:
    Alicja Kuźniewska, Alan Majeranowski, Daria Kowalska, Aleksandra Urban, Sara Henry, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (ICS) (rok: 2021, ), Wydawca: Elsevier / Molecular Immunology
    Data:
    konferencja 6-10 grudnia 2021
    Status:
    Published
  3. Assessment of the role of factor I in non-small cell lung cancer (NSCLC) progression.
    Authors:
    Anna Felberg-Miętka, Aleksandra Urban, Alicja Kuźniewska, Grzegorz Stasiłojć, Michał Bieńkowski, Ruben Pio, Luis Montuenga, Robbert Spaapen, Anna Blom, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (rok: 2021, ), Wydawca: Elsevier / Molecular Immunology
    Data:
    konferencja 6-10 grudnia
    Status:
    Published
    DOI:
    link to the publication
  4. Mutations resulting in formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics
    Authors:
    Anna Felberg-Miętka, Aleksandra Urban, Anna Borowska, Grzegorz Stasiłojć, Michał Taszner, Andrzej Hellmann, Anna M. Blom, Marcin Okrój
    Conference:
    17th European Meeting on Complement in Human Diseases, EMCHD 2019, Madrid, (Spain), (rok: 2019, ), Wydawca: Elsevier/Molecular Immunology
    Data:
    konferencja September 14-17, 2019
    Status:
    Published

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