Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of the complement system in tumorigenesis and therapeutic approaches.

2014/14/E/NZ6/00182

Keywords:

complement system monoclonal antibodies cancer

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ5_3: Pathogenesis of human diseases
  • NZ6_2: Clinical immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Gdański Uniwersytet Medyczny, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Okrój 

Number of co-investigators in the project: 3

Call: SONATA BIS 4 - announced on 2014-06-16

Amount awarded: 1 945 000 PLN

Project start date (Y-m-d): 2015-07-01

Project end date (Y-m-d): 2022-06-30

Project duration:: 84 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. wielodetekcyjny czytnik płytek z przystawką do obrazowania komórek (250 000 PLN)
  2. zestaw pipet automatycznych, wielostopniowych (3 000 PLN)
  3. inkubator do hodowli komórek in vitro (20 000 PLN)
  4. lodówka laboratoryjna (1 500 PLN)
  5. software (2 szt.) (20 000 PLN)
  6. termoblok - wytrząsarka stołowa (2 szt.) (10 000 PLN)
  7. komputer (2 szt.) (12 000 PLN)
  8. płuczka do testów immunoenzymatycznych.
  9. wytrząsarka orbitalna do inkuatora CO2.
  10. zamrażarka - 80 C (32 000 PLN)
  11. komora laminarna.
  12. zestaw pipet jedno i wielokanałowych (3 szt.) (10 500 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (4)
  1. Calcein release assay as a method for monitoring serum complement activity during monoclonal antibody therapy in patients with B-cell malignancies.
    Authors:
    Stasiłojć G, Felberg A, Urban A, Kowalska D, Ma S, Blom AM, Lundin J, Österborg A, Okrój M
    Academic press:
    Journal of Immunological Methods (rok: 2020, tom: 476, strony: 112675), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jim.2019.112675 - link to the publication
  2. Complement C4d-specific antibodies for the diagnosis of lung cancer.
    Authors:
    Ajona D, Okrój M, Pajares MJ, Agorreta J, Lozano MD, Zulueta JJ, Verri C, Roz L, Sozzi G, Pastorino U, Massion PP, Montuenga LM, Blom AM, Pio R.
    Academic press:
    Oncotarget (rok: 2018, tom: 9, strony: 6346-6355), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.23690 - link to the publication
  3. Monitoring of the Complement System Status in Patients With B-Cell Malignancies Treated With Rituximab
    Authors:
    Anna Felberg, Michał Taszner, Aleksandra Urban, Alan Majeranowski, Kinga Jaskuła, Aleksandra Jurkiewicz, Grzegorz Stasiłojć, Anna M Blom, Jan M Zaucha, Marcin Okrój
    Academic press:
    Frontiers in Immunology (rok: 2020, tom: 11, strony: 584509), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2020.584509 - link to the publication
  4. Mutations resulting in the formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics.
    Authors:
    Felberg A, Urban A, Borowska A, Stasiłojć G, Taszner M, Hellmann A, Blom AM, Okrój M.
    Academic press:
    Cancer Immunology Immunotherapy (rok: 2019, tom: 68, strony: 587-598), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-019-02304-0 - link to the publication
  5. Parameters critical for the effector mechanism of anti-CD20 antibodies revisited.
    Authors:
    Stasiłojć G, Felberg A, Okrój M.
    Academic press:
    British Journal of Haematology (rok: 2018, tom: 180, strony: 777-779), Wydawca: John Wiley at Sons Ltd.
    Status:
    Published
    DOI:
    10.1111/bjh.15130 - link to the publication
  6. Testing the Activity of Complement Convertases in Serum/Plasma for Diagnosis of C4NeF-Mediated C3 Glomerulonephritis.
    Authors:
    Blom AM, Corvillo F, Magda M, Stasiłojć G, Nozal P, Pérez-Valdivia MÁ, Cabello-Chaves V, Rodríguez de Córdoba S, López-Trascasa M, Okrój M
    Academic press:
    Journal of Clinical Immunology (rok: 2016, tom: 36, strony: 517-527), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10875-016-0290-5. - link to the publication
  7. Analysis of complement biomarkers in systemic sclerosis indicates a distinct pattern in scleroderma renal crisis.
    Authors:
    Okrój M, Johansson M, Saxne T, Blom AM, Hesselstrand R.
    Academic press:
    Arthritis Research and Therapy (rok: 2016, tom: 18, strony: 267), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13075-016-1168-x - link to the publication
  8. Measuring plasma C4D to monitor immune complexes in lupus nephritis
    Authors:
    Kraaij T, Nilsson SC, van Kooten C, Okrój M, Blom AM, Teng YO.
    Academic press:
    Lupus Science & Medicine (rok: 2019, tom: 6, strony: e000326), Wydawca: BMJ Journals
    Status:
    Published
    DOI:
    10.1136/lupus-2019-000326 - link to the publication
  9. New perspectives on complement mediated immunotherapy.
    Authors:
    Stasiłojć G, Österborg A, Blom AM, Okrój M.
    Academic press:
    Cancer Treatment Reviews (rok: 2016, tom: 45, strony: 68-75), Wydawca: Elsevier / Science Direct
    Status:
    Published
    DOI:
    10.1016/j.ctrv.2016.02.009 - link to the publication
  10. Overactivity of Alternative Pathway Convertases in Patients With Complement-Mediated Renal Diseases.
    Authors:
    Michels MAHM, van de Kar NCAJ, Okrój M, Blom AM, van Kraaij SAW, Volokhina EB1, van den Heuvel LPWJ
    Academic press:
    Frontiers in Immunology (rok: 2018, tom: 9, strony: 612), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.00612 - link to the publication
  11. Plasma C4d as marker for lupus nephritis in systemic lupus erythematosus.
    Authors:
    Martin M, Smoląg KI, Björk A, Gullstrand B, Okrój M, Leffler J, Jönsen A, Bengtsson AA, Blom AM
    Academic press:
    Arthritis Research and Therapy (rok: 2017, tom: 19, strony: 266), Wydawca: Biomed Central Ltd.
    Status:
    Published
    DOI:
    10.1186/s13075-017-1470-2. - link to the publication
  12. Complement Activation as a Helping Hand for Inflammophilic Pathogens and Cancer.
    Authors:
    Okrój M, Potempa J
    Academic press:
    Frontiers in Immunology (rok: 2019, tom: 9, strony: 3125), Wydawca: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fimmu.2018.03125 - link to the publication
  13. The complement system is activated in synovial fluid from subjects with knee injury and from patients with osteoarthritis
    Authors:
    Struglics A *, Okroj M * , Swärd P, Frobell R, Saxne T, Lohmander S, Blom AM. * - shared 1st authorship
    Academic press:
    Arthritis Research and Therapy (rok: 2016, tom: 18, strony: 223), Wydawca: PubMed Central
    Status:
    Published
    DOI:
    10.1186/s13075-016-1123-x - link to the publication
  14. Elevated expression of complement factor I in lung cancer cells associates with shorter survival - potentially via non-canonical mechanism.
    Authors:
    Anna Felberg, Michał Bieńkowski, Tomasz Stokowy, Kamil Myszczyński, Frida Mohlin, Alicja Kuźniewska, Ilse Jongerius, Robbert Spaapen, Miguel Mesa-Guzman, Luis M. Montuenga, Anna M. Blom, Ruben Pio, Marcin Okrój
    Academic press:
    Cancer Communications , Wydawca: Wiley and Sons
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Acquisition of complement-dependent cytotoxicity by type II anti-CD20 therapeutic antibody obinutuzumab.
    Authors:
    Alicja Kuźniewska, Alan Majeranowski, Daria Kowalska, Aleksandra Urban, Sara Henry, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (ICS) (rok: 2021, ), Wydawca: Elsevier / Molecular Immunology
    Data:
    konferencja 6-10 grudnia 2021
    Status:
    Published
  2. Changes in serum complement activity during anti-CD20 and anti-CD52 monoclonal antibody therapy in patients with chronic lymphocytic leukemia (CLL).
    Authors:
    Grzegorz Stasiłojć, Anna Felberg, Michał Taszner, Aleksandra Urban, Shuo Ma, Anna Blom, Jeanette Lundin, Anders Österborg, Marcin Okrój
    Conference:
    17th European Meeting on Complement in Human Diseases, EMCHD 2019, Madrid, (Spain) (rok: 2019, ), Wydawca: Elsevier/Molecular Immunology
    Data:
    konferencja September 14-17, 2019
    Status:
    Published
  3. Mutations resulting in formation of hyperactive complement convertases support cytocidal effect of anti-CD20 immunotherapeutics
    Authors:
    Anna Felberg-Miętka, Aleksandra Urban, Anna Borowska, Grzegorz Stasiłojć, Michał Taszner, Andrzej Hellmann, Anna M. Blom, Marcin Okrój
    Conference:
    17th European Meeting on Complement in Human Diseases, EMCHD 2019, Madrid, (Spain), (rok: 2019, ), Wydawca: Elsevier/Molecular Immunology
    Data:
    konferencja September 14-17, 2019
    Status:
    Published
  4. Assessment of the role of factor I in non-small cell lung cancer (NSCLC) progression.
    Authors:
    Anna Felberg-Miętka, Aleksandra Urban, Alicja Kuźniewska, Grzegorz Stasiłojć, Michał Bieńkowski, Ruben Pio, Luis Montuenga, Robbert Spaapen, Anna Blom, Marcin Okrój
    Conference:
    ICW – 2021 Virtual Workshop of the International Complement Society (rok: 2021, ), Wydawca: Elsevier / Molecular Immunology
    Data:
    konferencja 6-10 grudnia
    Status:
    Published
    DOI:
    link to the publication

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