Aging and multipotency of adult stem cells

2014/14/M/NZ3/00475

Keywords

Descriptors

  • NZ3_4: Starzenie
  • NZ3_8: Komórki macierzyste
  • NZ3_1: Biologia komórki

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Warszawski Uniwersytet Medyczny

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Mariusz Zdzisław Ratajczak

Number of co-investigators in the project: 3

Call

HARMONIA 6 – announced on 2014-06-16

Amount awarded
1 675 700 PLN
Project start date
2015-06-08
Project end date
2019-01-07
Project duration
43 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (26)

  1. Very Small Embryonic-Like Stem Cells (VSELs) An Update and Future Directions

    Authors:
    Mariusz Z. Ratajczak, Janina Ratajczak, Magda Kucia
    Academic press:
    Circulation Research (year: 2019, volume: 2, pages: 208-210), Publisher: American Heart Association
    Status:
    Published
    DOI:
    10.1161/CIRCRESAHA.118.314287. – link to the publication
  2. A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer

    Authors:
    Wojciech Marlicz, Agata Poniewierska-Baran, Sylwia Rzeszotek, Rafał Bartoszewski, Karolina Skonieczna-Żydecka, Teresa Starzyńska, Mariusz Z. Ratajczak
    Academic press:
    PLoS One (year: 2018, volume: 13, pages: e0189337), Publisher: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0189337. – link to the publication
  3. Innate Immunity and Mobilization of Hematopoietic Stem Cells

    Authors:
    Adamiak M., Ratajczak M.Z.
    Academic press:
    Current Stem Cell Reports (year: 2017, volume: 3, pages: 172-180), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s40778-017-0087-3 – link to the publication
  4. Parentally imprinted genes regulate hematopoiesis—new evidence from the Dlk1–Gtl2 locus

    Authors:
    Gabriela Schneider, Zachariah Payne Sellers, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Investigation (year: 2016, volume: 3, pages: 46027), Publisher: AME
    Status:
    Published
    DOI:
    10.21037/sci.2016.06.09 – link to the publication
  5. Toll-like receptor signaling-deficient mice are easy mobilizers: evidence that TLR signaling prevents mobilization of hematopoietic stem/progenitor cells in HO-1-dependent manner

    Authors:
    M Adamiak, A Abdelbaset-Ismail, M Kucia, J Ratajczak, M Z Ratajczak
    Academic press:
    Leukemia (year: 2016, volume: 30, pages: 2416-2419), Publisher: Springer
    Status:
    Published
    DOI:
    10.1038/leu.2016.236 – link to the publication
  6. Bone marrow-derived VSELs engraft as lung epithelial progenitor cells after bleomycin-induced lung injury

    Authors:
    Andrzej K. Ciechanowicz, Katarzyna Sielatycka, Monika Cymer, Marta Skoda, Malwina Suszynska, Kamila Bujko, Mariusz Z. Ratajczaka, Diane S. Krause, and Magdalena Kucia
    Academic press:
    Cells (year: 2021, volume: 10, pages: 46038), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10071570. – link to the publication
  7. Effect of Colorectal Cancer on the Number of Normal Stem Cells Circulating in Peripheral Blood

    Authors:
    Wojciech Marlicz, Katarzyna Sielatycka, Karol Serwin, Ewa Kubis, Marta Tkacz, Rafał Głuszko, Andrzej Białek, Teresa Starzyńska, Mariusz Z Ratajczak
    Academic press:
    Oncology Reports (year: 2016, volume: 36, pages: 3635-3642), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/or.2016.5179 – link to the publication
  8. Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells

    Authors:
    Ahmed Abdelbaset-Ismail, Sylwia Borkowska, Anna Janowska-Wieczorek, Torsten Tonn, Cesar Rodriguez, Marcin Moniuszko, Lukasz Bolkun, Janusz Koloczko, Andrzej Eljaszewicz, Janina Ratajczak, Mariusz Z. Ratajczak, Magda Kucia
    Academic press:
    Oncotarget (year: 2016, volume: 7, pages: 3033-3046), Publisher: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.6698 – link to the publication
  9. Human haematopoietic stem/progenitor cells express several functional sex hormone receptors

    Authors:
    Ahmed Abdelbaset‐Ismail, Malwina Suszynska, Sylwia Borkowska, Mateusz Adamiak, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak
    Academic press:
    Journal of Cellular and Molecular Medicine (year: 2016, volume: 20, pages: 134-146), Publisher: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/jcmm.12712 – link to the publication
  10. Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer?

    Authors:
    Mariusz Z. Ratajczak, Malwina Suszynska, Magda Kucia
    Academic press:
    Clinical and Translational Medicine (year: 2016, volume: 5, pages: 46030), Publisher: Springer
    Status:
    Published
    DOI:
    10.1186/s40169-016-0113-6 – link to the publication
  11. Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: therapeutic implications

    Authors:
    AGATA PONIEWIERSKA-BARAN, GABRIELA SCHNEIDER, WENYUE SUN, AHMED ABDELBASET-ISMAIL, FREDERIC G. BARR, MARIUSZ Z. RATAJCZAK
    Academic press:
    International Journal of Oncology (year: 2016, volume: 48, pages: 1815-1824), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3439 – link to the publication
  12. Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies.

    Authors:
    Mariusz Z. Ratajczak, Kamila Bujko, Wojciech Wojakowski
    Academic press:
    Polish Archives of Internal Medicine (year: 2016, volume: 126, pages: 879-890), Publisher: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.3644 – link to the publication
  13. Novel View on Umbilical Cord Blood and Maternal Peripheral Blood-an Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal-Maternal Circulation Barrier.

    Authors:
    Sielatycka K., Poniewierska-Baran A., Nurek K., Torbé A., Ratajczak M.Z.
    Academic press:
    Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 774-780), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s12015-017-9763-z. – link to the publication
  14. Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.

    Authors:
    Huiyan Jin , Andrzej K. Ciechanowicz , Alanna R. Kaplan , Lin Wang , Ping-Xia Zhang , Yi-Chien Lu , Rachel E. Tobin , Brooke A. Tobin , Lauren Cohn , Caroline J. Zeiss , Patty J. Lee , Emanuela M. Bruscia , and Diane S. Krause
    Academic press:
    Am J Physiol Lung Cell Mol Physiol. (year: 2018, volume: 5, pages: 882-892), Publisher: American Journal of Physiology
    Status:
    Published
    DOI:
    10.1152/ajplung.00418.2017. – link to the publication
  15. Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines

    Authors:
    Ahmed Abdelbaset-Ismail, Daniel Pedziwiatr, Ewa Suszyńska, Sylwia Sluczanowska-Glabowska, Gabriela Schneider, Sham S. Kakar, Mariusz Z. Ratajczak
    Academic press:
    Journal of Ovarian Research (year: 2016, volume: 9, pages: 46034), Publisher: Springer
    Status:
    Published
    DOI:
    10.1186/s13048-016-0235-x – link to the publication
  16. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells

    Authors:
    Gabriela Schneider, Talita Glaser, Claudiana Lameu, Ahmed Abdelbaset-Ismail, Zachariah Payne Sellers, Marcin Moniuszko, Henning Ulrich, Mariusz Z. Ratajczak
    Academic press:
    Molecular Cancer (year: 2015, volume: 14, pages: 46037), Publisher: Springer
    Status:
    Published
    DOI:
    10.1186/s12943-015-0469-z – link to the publication
  17. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells

    Authors:
    Adamiak M., Chelvarajan L., Lynch Kevin R., Santos W., Abdel-Latif A., Ratajczak M.
    Academic press:
    ONCOTARGET (year: 2017, volume: 8, pages: 65588-65600), Publisher: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.19514 – link to the publication
  18. Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

    Authors:
    Adamiak M., Abdelbaset-Ismail A. Suszyńska M., Abdel-Latif A., Ratajczak J., Ratajczak M
    Academic press:
    LEUKEMIA (year: 2017, volume: 31, pages: 262-265), Publisher: Nature
    Status:
    Published
    DOI:
    10.1038/leu.2016.278 – link to the publication
  19. Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging

    Authors:
    Ratajczak M., Bartke A., Darzynkiewicz Z.
    Academic press:
    Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 443-453), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-017-9728-2. – link to the publication
  20. A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells

    Authors:
    Ratajczak M., Ratajczak J., Suszyńska M., Miller Donald M., Kucia M., Dong-Myung S.
    Academic press:
    CIRCULATION RESEARCH (year: 2017, volume: 120, pages: 166-178), Publisher: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1161/CIRCRESAHA.116.309362. – link to the publication
  21. Why are hematopoietic stem cells so 'sexy'? on a search for developmental explanation

    Authors:
    Ratajczak M.
    Academic press:
    LEUKEMIA (year: 2017, volume: 31, pages: 1671-1677), Publisher: Nature
    Status:
    Published
    DOI:
    10.1038/leu.2017.148. – link to the publication
  22. Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

    Authors:
    Adamiak M., Abdelbaset-Ismail A. Suszyńska M,, Abdel-Latif A,, Ratajczak J, Ratajczak M
    Academic press:
    LEUKEMIA (year: 2017, volume: 31, pages: 262-265), Publisher: Nature
    Status:
    Published
    DOI:
    10.1038/leu.2016.278 – link to the publication
  23. Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking

    Authors:
    Adamiak M., Abdelbaset-Ismail A., Moore J.B. 4th, Zhao J., Abdel-Latif A., Wysoczynski M., Ratajczak M.Z.
    Academic press:
    Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 92-103), Publisher: Springer Link
    Status:
    Published
    DOI:
    10.1007/s12015-016-9693-1. – link to the publication
  24. Pituitary sex hormones enhance the pro-metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase-1

    Authors:
    Abdelbaset-Ismail A., Pedziwiatr D., Schneider G., Niklinski J., Charkiewicz R., Moniuszko M. Kucia M., Ratajczak M.
    Academic press:
    International Journal of Oncology (year: 2017, volume: 50, pages: 317-328), Publisher: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3787. – link to the publication
  25. Stem cells and their potential clinical applications in psychiatric disorders

    Authors:
    Ratajczak M., Ciechanowicz A., Kucharska-Mazur J., Samochowiec J.
    Academic press:
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (year: 2018, volume: 80, pages: 46090), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2017.04.020. – link to the publication
  26. Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization

    Authors:
    Bujko K., Rzeszotek S., Hoehlig K., Yan J., Vater A., Ratajczak M.Z.
    Academic press:
    Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 793-800), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-017-9769-6. – link to the publication

Articles in post-conference publications (2)

  1. UDZIAŁ SFINGOZYNO-1-FOSFORANU WE WSZCZEPIENIU I ZASIEDLANIU NISZY SZPIKOWEJ PRZEZ KRWIOTWÓRCZE KOMÓRKI MACIERZYSTE

    Authors:
    Mateusz Adamiak, Sylwia Borkowska, Marcin Wysoczyński, Malwina Suszyńska, Magdalena Kucia, Ahmed Abdel-Latif, Janina Ratajczak, Mariusz Z. Ratajczak
    Conference:
    XXVII Zjazd Polskiego Towarzystwa Hematologów i Transfuzjologów (year: 2017, pages: 195), Publisher: Acta Haematologica Polonica
    Date:
    conference 21-23.09
    Status:
    Published
  2. Preliminary studies on the assessment of the proliferative potential of type II pneumocytes and bronchoalveolar stem cells isolated at various stages of bleomycin-induced lung injury.

    Authors:
    Andrzej K. Ciechanowicz, Daniel Pędziwiatr, Zuzanna Wichrzycka, Magdalena Kucia, Diane S. Krause
    Conference:
    4th Baltic Stem Cell Meeting (BSCM) (year: 2018, pages: Abstract 005), Publisher: Wydawnictwo Warszawskiego Uniwersytetu Medycznego
    Date:
    conference 28-30.09
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski