Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Aging and multipotency of adult stem cells

2014/14/M/NZ3/00475

Keywords:

stem cell regeneration aging

Descriptors:

  • NZ3_4: Ageing
  • NZ3_8: Stem cell biology
  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Ratajczak 

Number of co-investigators in the project: 3

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 1 675 700 PLN

Project start date (Y-m-d): 2015-06-08

Project end date (Y-m-d): 2019-01-07

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (26)
  • Articles in post-conference publications (2)
  1. Parentally imprinted genes regulate hematopoiesis—new evidence from the Dlk1–Gtl2 locus
    Authors:
    Gabriela Schneider, Zachariah Payne Sellers, Mariusz Z. Ratajczak
    Academic press:
    Stem Cell Investigation (rok: 2016, tom: 3, strony: 45296), Wydawca: AME
    Status:
    Published
    DOI:
    10.21037/sci.2016.06.09 - link to the publication
  2. Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization
    Authors:
    Bujko K., Rzeszotek S., Hoehlig K., Yan J., Vater A., Ratajczak M.Z.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2017, tom: 13, strony: 793-800), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-017-9769-6. - link to the publication
  3. Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.
    Authors:
    Huiyan Jin , Andrzej K. Ciechanowicz , Alanna R. Kaplan , Lin Wang , Ping-Xia Zhang , Yi-Chien Lu , Rachel E. Tobin , Brooke A. Tobin , Lauren Cohn , Caroline J. Zeiss , Patty J. Lee , Emanuela M. Bruscia , and Diane S. Krause
    Academic press:
    Am J Physiol Lung Cell Mol Physiol. (rok: 2018, tom: 5, strony: 882-892), Wydawca: American Journal of Physiology
    Status:
    Published
    DOI:
    10.1152/ajplung.00418.2017. - link to the publication
  4. A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells
    Authors:
    Ratajczak M., Ratajczak J., Suszyńska M., Miller Donald M., Kucia M., Dong-Myung S.
    Academic press:
    CIRCULATION RESEARCH (rok: 2017, tom: 120, strony: 166-178), Wydawca: Lippincott Williams & Wilkins
    Status:
    Published
    DOI:
    10.1161/CIRCRESAHA.116.309362. - link to the publication
  5. Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells
    Authors:
    Gabriela Schneider, Talita Glaser, Claudiana Lameu, Ahmed Abdelbaset-Ismail, Zachariah Payne Sellers, Marcin Moniuszko, Henning Ulrich, Mariusz Z. Ratajczak
    Academic press:
    Molecular Cancer (rok: 2015, tom: 14, strony: 45306), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s12943-015-0469-z - link to the publication
  6. Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging
    Authors:
    Ratajczak M., Bartke A., Darzynkiewicz Z.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2017, tom: 13, strony: 443-453), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-017-9728-2. - link to the publication
  7. Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies.
    Authors:
    Mariusz Z. Ratajczak, Kamila Bujko, Wojciech Wojakowski
    Academic press:
    Polish Archives of Internal Medicine (rok: 2016, tom: 126, strony: 879-890), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.3644 - link to the publication
  8. Toll-like receptor signaling-deficient mice are easy mobilizers: evidence that TLR signaling prevents mobilization of hematopoietic stem/progenitor cells in HO-1-dependent manner
    Authors:
    M Adamiak, A Abdelbaset-Ismail, M Kucia, J Ratajczak, M Z Ratajczak
    Academic press:
    Leukemia (rok: 2016, tom: 30, strony: 2416-2419), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1038/leu.2016.236 - link to the publication
  9. Bone marrow-derived VSELs engraft as lung epithelial progenitor cells after bleomycin-induced lung injury
    Authors:
    Andrzej K. Ciechanowicz, Katarzyna Sielatycka, Monika Cymer, Marta Skoda, Malwina Suszynska, Kamila Bujko, Mariusz Z. Ratajczaka, Diane S. Krause, and Magdalena Kucia
    Academic press:
    Cells (rok: 2021, tom: 10, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10071570. - link to the publication
  10. Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: therapeutic implications
    Authors:
    AGATA PONIEWIERSKA-BARAN, GABRIELA SCHNEIDER, WENYUE SUN, AHMED ABDELBASET-ISMAIL, FREDERIC G. BARR, MARIUSZ Z. RATAJCZAK
    Academic press:
    International Journal of Oncology (rok: 2016, tom: 48, strony: 1815-1824), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3439 - link to the publication
  11. Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking
    Authors:
    Adamiak M., Abdelbaset-Ismail A., Moore J.B. 4th, Zhao J., Abdel-Latif A., Wysoczynski M., Ratajczak M.Z.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2017, tom: 13, strony: 92-103), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s12015-016-9693-1. - link to the publication
  12. Innate Immunity and Mobilization of Hematopoietic Stem Cells
    Authors:
    Adamiak M., Ratajczak M.Z.
    Academic press:
    Current Stem Cell Reports (rok: 2017, tom: 3, strony: 172-180), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s40778-017-0087-3 - link to the publication
  13. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells
    Authors:
    Adamiak M., Chelvarajan L., Lynch Kevin R., Santos W., Abdel-Latif A., Ratajczak M.
    Academic press:
    ONCOTARGET (rok: 2017, tom: 8, strony: 65588-65600), Wydawca: Impact Journals, LLC
    Status:
    Published
    DOI:
    10.18632/oncotarget.19514 - link to the publication
  14. Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades
    Authors:
    Adamiak M., Abdelbaset-Ismail A. Suszyńska M., Abdel-Latif A., Ratajczak J., Ratajczak M
    Academic press:
    LEUKEMIA (rok: 2017, tom: 31, strony: 262-265), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/leu.2016.278 - link to the publication
  15. Pituitary sex hormones enhance the pro-metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase-1
    Authors:
    Abdelbaset-Ismail A., Pedziwiatr D., Schneider G., Niklinski J., Charkiewicz R., Moniuszko M. Kucia M., Ratajczak M.
    Academic press:
    International Journal of Oncology (rok: 2017, tom: 50, strony: 317-328), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/ijo.2016.3787. - link to the publication
  16. Effect of Colorectal Cancer on the Number of Normal Stem Cells Circulating in Peripheral Blood
    Authors:
    Wojciech Marlicz, Katarzyna Sielatycka, Karol Serwin, Ewa Kubis, Marta Tkacz, Rafał Głuszko, Andrzej Białek, Teresa Starzyńska, Mariusz Z Ratajczak
    Academic press:
    Oncology Reports (rok: 2016, tom: 36, strony: 3635-3642), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/or.2016.5179 - link to the publication
  17. Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades
    Authors:
    Adamiak M., Abdelbaset-Ismail A. Suszyńska M,, Abdel-Latif A,, Ratajczak J, Ratajczak M
    Academic press:
    LEUKEMIA (rok: 2017, tom: 31, strony: 262-265), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/leu.2016.278 - link to the publication
  18. Very Small Embryonic-Like Stem Cells (VSELs) An Update and Future Directions
    Authors:
    Mariusz Z. Ratajczak, Janina Ratajczak, Magda Kucia
    Academic press:
    Circulation Research (rok: 2019, tom: 2, strony: 208-210), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/CIRCRESAHA.118.314287. - link to the publication
  19. A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer
    Authors:
    Wojciech Marlicz, Agata Poniewierska-Baran, Sylwia Rzeszotek, Rafał Bartoszewski, Karolina Skonieczna-Żydecka, Teresa Starzyńska, Mariusz Z. Ratajczak
    Academic press:
    PLoS One (rok: 2018, tom: 13, strony: e0189337), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0189337. - link to the publication
  20. Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer?
    Authors:
    Mariusz Z. Ratajczak, Malwina Suszynska, Magda Kucia
    Academic press:
    Clinical and Translational Medicine (rok: 2016, tom: 5, strony: 45299), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s40169-016-0113-6 - link to the publication
  21. Human haematopoietic stem/progenitor cells express several functional sex hormone receptors
    Authors:
    Ahmed Abdelbaset‐Ismail, Malwina Suszynska, Sylwia Borkowska, Mateusz Adamiak, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak
    Academic press:
    Journal of Cellular and Molecular Medicine (rok: 2016, tom: 20, strony: 134-146), Wydawca: John Wiley & Sons
    Status:
    Published
    DOI:
    10.1111/jcmm.12712 - link to the publication
  22. Novel View on Umbilical Cord Blood and Maternal Peripheral Blood-an Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal-Maternal Circulation Barrier.
    Authors:
    Sielatycka K., Poniewierska-Baran A., Nurek K., Torbé A., Ratajczak M.Z.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2017, tom: 13, strony: 774-780), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s12015-017-9763-z. - link to the publication
  23. Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells
    Authors:
    Ahmed Abdelbaset-Ismail, Sylwia Borkowska, Anna Janowska-Wieczorek, Torsten Tonn, Cesar Rodriguez, Marcin Moniuszko, Lukasz Bolkun, Janusz Koloczko, Andrzej Eljaszewicz, Janina Ratajczak, Mariusz Z. Ratajczak, Magda Kucia
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 3033-3046), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.6698 - link to the publication
  24. Stem cells and their potential clinical applications in psychiatric disorders
    Authors:
    Ratajczak M., Ciechanowicz A., Kucharska-Mazur J., Samochowiec J.
    Academic press:
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (rok: 2018, tom: 80, strony: 45360), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pnpbp.2017.04.020. - link to the publication
  25. Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines
    Authors:
    Ahmed Abdelbaset-Ismail, Daniel Pedziwiatr, Ewa Suszyńska, Sylwia Sluczanowska-Glabowska, Gabriela Schneider, Sham S. Kakar, Mariusz Z. Ratajczak
    Academic press:
    Journal of Ovarian Research (rok: 2016, tom: 9, strony: 45303), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s13048-016-0235-x - link to the publication
  26. Why are hematopoietic stem cells so 'sexy'? on a search for developmental explanation
    Authors:
    Ratajczak M.
    Academic press:
    LEUKEMIA (rok: 2017, tom: 31, strony: 1671-1677), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/leu.2017.148. - link to the publication
  1. UDZIAŁ SFINGOZYNO-1-FOSFORANU WE WSZCZEPIENIU I ZASIEDLANIU NISZY SZPIKOWEJ PRZEZ KRWIOTWÓRCZE KOMÓRKI MACIERZYSTE
    Authors:
    Mateusz Adamiak, Sylwia Borkowska, Marcin Wysoczyński, Malwina Suszyńska, Magdalena Kucia, Ahmed Abdel-Latif, Janina Ratajczak, Mariusz Z. Ratajczak
    Conference:
    XXVII Zjazd Polskiego Towarzystwa Hematologów i Transfuzjologów (rok: 2017, ), Wydawca: Acta Haematologica Polonica
    Data:
    konferencja 21-23.09
    Status:
    Published
  2. Preliminary studies on the assessment of the proliferative potential of type II pneumocytes and bronchoalveolar stem cells isolated at various stages of bleomycin-induced lung injury.
    Authors:
    Andrzej K. Ciechanowicz, Daniel Pędziwiatr, Zuzanna Wichrzycka, Magdalena Kucia, Diane S. Krause
    Conference:
    4th Baltic Stem Cell Meeting (BSCM) (rok: 2018, ), Wydawca: Wydawnictwo Warszawskiego Uniwersytetu Medycznego
    Data:
    konferencja 28-30.09
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy