Aging and multipotency of adult stem cells
2014/14/M/NZ3/00475
Keywords
Descriptors
- NZ3_4: Starzenie
- NZ3_8: Komórki macierzyste
- NZ3_1: Biologia komórki
Panel
NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology
Host institution
Warszawski Uniwersytet Medyczny
Voivodeship: mazowieckie
Principal investigator (from the host institution)
prof. Mariusz Zdzisław Ratajczak
Number of co-investigators in the project: 3
Call
HARMONIA 6 – announced on 2014-06-16
- Amount awarded
- 1 675 700 PLN
- Project start date
- 2015-06-08
- Project end date
- 2019-01-07
- Project duration
- 43 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (26)
-
Very Small Embryonic-Like Stem Cells (VSELs) An Update and Future Directions
- Authors:
- Mariusz Z. Ratajczak, Janina Ratajczak, Magda Kucia
- Academic press:
- Circulation Research (year: 2019, volume: 2, pages: 208-210), Publisher: American Heart Association
- Status:
- Published
- DOI:
- 10.1161/CIRCRESAHA.118.314287. – link to the publication
-
A novel potential role of pituitary gonadotropins in the pathogenesis of human colorectal cancer
- Authors:
- Wojciech Marlicz, Agata Poniewierska-Baran, Sylwia Rzeszotek, Rafał Bartoszewski, Karolina Skonieczna-Żydecka, Teresa Starzyńska, Mariusz Z. Ratajczak
- Academic press:
- PLoS One (year: 2018, volume: 13, pages: e0189337), Publisher: Public Library of Science
- Status:
- Published
- DOI:
- 10.1371/journal.pone.0189337. – link to the publication
-
Innate Immunity and Mobilization of Hematopoietic Stem Cells
- Authors:
- Adamiak M., Ratajczak M.Z.
- Academic press:
- Current Stem Cell Reports (year: 2017, volume: 3, pages: 172-180), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s40778-017-0087-3 – link to the publication
-
Parentally imprinted genes regulate hematopoiesis—new evidence from the Dlk1–Gtl2 locus
- Authors:
- Gabriela Schneider, Zachariah Payne Sellers, Mariusz Z. Ratajczak
- Academic press:
- Stem Cell Investigation (year: 2016, volume: 3, pages: 46027), Publisher: AME
- Status:
- Published
- DOI:
- 10.21037/sci.2016.06.09 – link to the publication
-
Toll-like receptor signaling-deficient mice are easy mobilizers: evidence that TLR signaling prevents mobilization of hematopoietic stem/progenitor cells in HO-1-dependent manner
- Authors:
- M Adamiak, A Abdelbaset-Ismail, M Kucia, J Ratajczak, M Z Ratajczak
- Academic press:
- Leukemia (year: 2016, volume: 30, pages: 2416-2419), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1038/leu.2016.236 – link to the publication
-
Bone marrow-derived VSELs engraft as lung epithelial progenitor cells after bleomycin-induced lung injury
- Authors:
- Andrzej K. Ciechanowicz, Katarzyna Sielatycka, Monika Cymer, Marta Skoda, Malwina Suszynska, Kamila Bujko, Mariusz Z. Ratajczaka, Diane S. Krause, and Magdalena Kucia
- Academic press:
- Cells (year: 2021, volume: 10, pages: 46038), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/cells10071570. – link to the publication
-
Effect of Colorectal Cancer on the Number of Normal Stem Cells Circulating in Peripheral Blood
- Authors:
- Wojciech Marlicz, Katarzyna Sielatycka, Karol Serwin, Ewa Kubis, Marta Tkacz, Rafał Głuszko, Andrzej Białek, Teresa Starzyńska, Mariusz Z Ratajczak
- Academic press:
- Oncology Reports (year: 2016, volume: 36, pages: 3635-3642), Publisher: Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/or.2016.5179 – link to the publication
-
Novel evidence that pituitary gonadotropins directly stimulate human leukemic cells-studies of myeloid cell lines and primary patient AML and CML cells
- Authors:
- Ahmed Abdelbaset-Ismail, Sylwia Borkowska, Anna Janowska-Wieczorek, Torsten Tonn, Cesar Rodriguez, Marcin Moniuszko, Lukasz Bolkun, Janusz Koloczko, Andrzej Eljaszewicz, Janina Ratajczak, Mariusz Z. Ratajczak, Magda Kucia
- Academic press:
- Oncotarget (year: 2016, volume: 7, pages: 3033-3046), Publisher: Impact Journals
- Status:
- Published
- DOI:
- 10.18632/oncotarget.6698 – link to the publication
-
Human haematopoietic stem/progenitor cells express several functional sex hormone receptors
- Authors:
- Ahmed Abdelbaset‐Ismail, Malwina Suszynska, Sylwia Borkowska, Mateusz Adamiak, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak
- Academic press:
- Journal of Cellular and Molecular Medicine (year: 2016, volume: 20, pages: 134-146), Publisher: John Wiley & Sons
- Status:
- Published
- DOI:
- 10.1111/jcmm.12712 – link to the publication
-
Does it make sense to target one tumor cell chemotactic factor or its receptor when several chemotactic axes are involved in metastasis of the same cancer?
- Authors:
- Mariusz Z. Ratajczak, Malwina Suszynska, Magda Kucia
- Academic press:
- Clinical and Translational Medicine (year: 2016, volume: 5, pages: 46030), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1186/s40169-016-0113-6 – link to the publication
-
Human rhabdomyosarcoma cells express functional pituitary and gonadal sex hormone receptors: therapeutic implications
- Authors:
- AGATA PONIEWIERSKA-BARAN, GABRIELA SCHNEIDER, WENYUE SUN, AHMED ABDELBASET-ISMAIL, FREDERIC G. BARR, MARIUSZ Z. RATAJCZAK
- Academic press:
- International Journal of Oncology (year: 2016, volume: 48, pages: 1815-1824), Publisher: Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/ijo.2016.3439 – link to the publication
-
Stem cells and clinical practice: new advances and challenges at the time of emerging problems with induced pluripotent stem cell therapies.
- Authors:
- Mariusz Z. Ratajczak, Kamila Bujko, Wojciech Wojakowski
- Academic press:
- Polish Archives of Internal Medicine (year: 2016, volume: 126, pages: 879-890), Publisher: Medycyna Praktyczna
- Status:
- Published
- DOI:
- 10.20452/pamw.3644 – link to the publication
-
Novel View on Umbilical Cord Blood and Maternal Peripheral Blood-an Evidence for an Increase in the Number of Circulating Stem Cells on Both Sides of the Fetal-Maternal Circulation Barrier.
- Authors:
- Sielatycka K., Poniewierska-Baran A., Nurek K., Torbé A., Ratajczak M.Z.
- Academic press:
- Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 774-780), Publisher: Springer Link
- Status:
- Published
- DOI:
- 10.1007/s12015-017-9763-z. – link to the publication
-
Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair.
- Authors:
- Huiyan Jin , Andrzej K. Ciechanowicz , Alanna R. Kaplan , Lin Wang , Ping-Xia Zhang , Yi-Chien Lu , Rachel E. Tobin , Brooke A. Tobin , Lauren Cohn , Caroline J. Zeiss , Patty J. Lee , Emanuela M. Bruscia , and Diane S. Krause
- Academic press:
- Am J Physiol Lung Cell Mol Physiol. (year: 2018, volume: 5, pages: 882-892), Publisher: American Journal of Physiology
- Status:
- Published
- DOI:
- 10.1152/ajplung.00418.2017. – link to the publication
-
Vitamin D3 stimulates embryonic stem cells but inhibits migration and growth of ovarian cancer and teratocarcinoma cell lines
- Authors:
- Ahmed Abdelbaset-Ismail, Daniel Pedziwiatr, Ewa Suszyńska, Sylwia Sluczanowska-Glabowska, Gabriela Schneider, Sham S. Kakar, Mariusz Z. Ratajczak
- Academic press:
- Journal of Ovarian Research (year: 2016, volume: 9, pages: 46034), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1186/s13048-016-0235-x – link to the publication
-
Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells
- Authors:
- Gabriela Schneider, Talita Glaser, Claudiana Lameu, Ahmed Abdelbaset-Ismail, Zachariah Payne Sellers, Marcin Moniuszko, Henning Ulrich, Mariusz Z. Ratajczak
- Academic press:
- Molecular Cancer (year: 2015, volume: 14, pages: 46037), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1186/s12943-015-0469-z – link to the publication
-
Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells
- Authors:
- Adamiak M., Chelvarajan L., Lynch Kevin R., Santos W., Abdel-Latif A., Ratajczak M.
- Academic press:
- ONCOTARGET (year: 2017, volume: 8, pages: 65588-65600), Publisher: Impact Journals, LLC
- Status:
- Published
- DOI:
- 10.18632/oncotarget.19514 – link to the publication
-
Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades
- Authors:
- Adamiak M., Abdelbaset-Ismail A. Suszyńska M., Abdel-Latif A., Ratajczak J., Ratajczak M
- Academic press:
- LEUKEMIA (year: 2017, volume: 31, pages: 262-265), Publisher: Nature
- Status:
- Published
- DOI:
- 10.1038/leu.2016.278 – link to the publication
-
Prolonged Growth Hormone/Insulin/Insulin-like Growth Factor Nutrient Response Signaling Pathway as a Silent Killer of Stem Cells and a Culprit in Aging
- Authors:
- Ratajczak M., Bartke A., Darzynkiewicz Z.
- Academic press:
- Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 443-453), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12015-017-9728-2. – link to the publication
-
A Novel View of the Adult Stem Cell Compartment From the Perspective of a Quiescent Population of Very Small Embryonic-Like Stem Cells
- Authors:
- Ratajczak M., Ratajczak J., Suszyńska M., Miller Donald M., Kucia M., Dong-Myung S.
- Academic press:
- CIRCULATION RESEARCH (year: 2017, volume: 120, pages: 166-178), Publisher: Lippincott Williams & Wilkins
- Status:
- Published
- DOI:
- 10.1161/CIRCRESAHA.116.309362. – link to the publication
-
Why are hematopoietic stem cells so 'sexy'? on a search for developmental explanation
- Authors:
- Ratajczak M.
- Academic press:
- LEUKEMIA (year: 2017, volume: 31, pages: 1671-1677), Publisher: Nature
- Status:
- Published
- DOI:
- 10.1038/leu.2017.148. – link to the publication
-
Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades
- Authors:
- Adamiak M., Abdelbaset-Ismail A. Suszyńska M,, Abdel-Latif A,, Ratajczak J, Ratajczak M
- Academic press:
- LEUKEMIA (year: 2017, volume: 31, pages: 262-265), Publisher: Nature
- Status:
- Published
- DOI:
- 10.1038/leu.2016.278 – link to the publication
-
Inducible Nitric Oxide Synthase (iNOS) Is a Novel Negative Regulator of Hematopoietic Stem/Progenitor Cell Trafficking
- Authors:
- Adamiak M., Abdelbaset-Ismail A., Moore J.B. 4th, Zhao J., Abdel-Latif A., Wysoczynski M., Ratajczak M.Z.
- Academic press:
- Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 92-103), Publisher: Springer Link
- Status:
- Published
- DOI:
- 10.1007/s12015-016-9693-1. – link to the publication
-
Pituitary sex hormones enhance the pro-metastatic potential of human lung cancer cells by downregulating the intracellular expression of heme oxygenase-1
- Authors:
- Abdelbaset-Ismail A., Pedziwiatr D., Schneider G., Niklinski J., Charkiewicz R., Moniuszko M. Kucia M., Ratajczak M.
- Academic press:
- International Journal of Oncology (year: 2017, volume: 50, pages: 317-328), Publisher: Spandidos Publications
- Status:
- Published
- DOI:
- 10.3892/ijo.2016.3787. – link to the publication
-
Stem cells and their potential clinical applications in psychiatric disorders
- Authors:
- Ratajczak M., Ciechanowicz A., Kucharska-Mazur J., Samochowiec J.
- Academic press:
- PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (year: 2018, volume: 80, pages: 46090), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.pnpbp.2017.04.020. – link to the publication
-
Signaling of the Complement Cleavage Product Anaphylatoxin C5a Through C5aR (CD88) Contributes to Pharmacological Hematopoietic Stem Cell Mobilization
- Authors:
- Bujko K., Rzeszotek S., Hoehlig K., Yan J., Vater A., Ratajczak M.Z.
- Academic press:
- Stem Cell Reviews and Reports (year: 2017, volume: 13, pages: 793-800), Publisher: Springer
- Status:
- Published
- DOI:
- 10.1007/s12015-017-9769-6. – link to the publication
Articles in post-conference publications (2)
-
UDZIAŁ SFINGOZYNO-1-FOSFORANU WE WSZCZEPIENIU I ZASIEDLANIU NISZY SZPIKOWEJ PRZEZ KRWIOTWÓRCZE KOMÓRKI MACIERZYSTE
- Authors:
- Mateusz Adamiak, Sylwia Borkowska, Marcin Wysoczyński, Malwina Suszyńska, Magdalena Kucia, Ahmed Abdel-Latif, Janina Ratajczak, Mariusz Z. Ratajczak
- Conference:
- XXVII Zjazd Polskiego Towarzystwa Hematologów i Transfuzjologów (year: 2017, pages: 195), Publisher: Acta Haematologica Polonica
- Date:
- conference 21-23.09
- Status:
- Published
-
Preliminary studies on the assessment of the proliferative potential of type II pneumocytes and bronchoalveolar stem cells isolated at various stages of bleomycin-induced lung injury.
- Authors:
- Andrzej K. Ciechanowicz, Daniel Pędziwiatr, Zuzanna Wichrzycka, Magdalena Kucia, Diane S. Krause
- Conference:
- 4th Baltic Stem Cell Meeting (BSCM) (year: 2018, pages: Abstract 005), Publisher: Wydawnictwo Warszawskiego Uniwersytetu Medycznego
- Date:
- conference 28-30.09
- Status:
- Published