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Information on the principal investigator and host institution

Information of the project and the call

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Role of HAX1 in the regulation of mRNA and its implications for cell invasive potential.

2014/14/M/NZ1/00437

Keywords:

RNA immunoprecipitation metastatic protrusions RNA-protein interaction

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Ewa Grzybowska 

Number of co-investigators in the project: 6

Call: HARMONIA 6 - announced on 2014-06-16

Amount awarded: 552 000 PLN

Project start date (Y-m-d): 2015-07-01

Project end date (Y-m-d): 2019-12-31

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (10)
  1. The interactome of multifunctional HAX1 protein suggests its role in the regulation of energy metabolism, de-aggregation, cytoskeleton organization and RNA-processing.
    Authors:
    Wakula M, Balcerak A, Rubel T, Chmielarczyk M, Konopinski R, Lyczek F, Grzybowska EA.
    Academic press:
    Bioscience Reports (rok: 2020, tom: 40, strony: BSR20203094), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BSR20203094 - link to the publication
  2. Quantification of Cell-Substrate Adhesion Area and Cell Shape Distributions in MCF7 Cell Monolayers
    Authors:
    Wakula M, Balcerak A, Smietanka U, Chmielarczyk M, Konopiński R, Grzybowska EA.
    Academic press:
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (rok: 2020, tom: 160, strony: e61461), Wydawca: JoVE
    Status:
    Published
    DOI:
    10.3791/61461 - link to the publication
  3. HAX1 impact on collective cell migration, cell adhesion, and cell shape is linked to the regulation of actomyosin contractility
    Authors:
    Anna Balcerak , Alicja Trebinska-Stryjewska , Maciej Wakula , Mateusz Chmielarczyk , Urszula Smietanka , Tymon Rubel , Ryszard Konopinski , Ewelina Macech-Klicka , Renata Zub , and Ewa Anna Grzybowska
    Academic press:
    Molecular Biology of the Cell (rok: 2019, tom: 30(25), strony: -), Wydawca: AMER SOC CELL BIOLOGY
    Status:
    Published
    DOI:
    10.1091/mbc.E19-05-0304 - link to the publication
  4. Protein Binding to Cis-Motifs in mRNAs Coding Sequence Is Common and Regulates Transcript Stability and the Rate of Translation
    Authors:
    Grzybowska EA, Wakula M
    Academic press:
    Cells (rok: 2021, tom: 10(11), 2910, strony: -), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10112910 - link to the publication
  5. The RNA-binding landscape of HAX1 protein indicates its involvement in ribosome biogenesis and translation.
    Authors:
    Anna Balcerak,, Ewelina Macech-Klicka, Maciej Wakula,Rafal Tomecki, Krzysztof Goryca, Malgorzata Rydzanicz, Mateusz Chmielarczyk, Malgorzata Szostakowska-Rodzos, Marta Wisniewska, Filip Lyczek, Aleksandra Helwak, David Tollervey, Grzegorz Kudla and Ewa A.Grzybowska
    Academic press:
    Cells (rok: 2022, tom: 11(19), 2943, strony: -), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells11192943 - link to the publication
  6. Cytoplasmic HAX1 is an independent risk factor for breast cancer metastasis
    Authors:
    Alicja Trebinska-Stryjewska, Lukasz Szafron, Alina Rembiszewska, Maciej Wakula, Sylwia Tabor, Renata Sienkiewicz, Joanna Owczarek, Anna Balcerak, Anna Felisiak-Golabek, and Ewa Anna Grzybowska
    Academic press:
    Journal of Oncology (rok: 2019, tom: Volume 2019, strony: -), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/6375025 - link to the publication
  7. The calcium binding properties and structure prediction of the Hax-1 protein
    Authors:
    Anna Balcerak, Sebastian Rowinski, Lukasz M. Szafron and Ewa A. Grzybowska
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64(3), strony: 537-542), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2017_1529 - link to the publication
  8. Calcium-Binding Proteins with Disordered Structure and Their Role in Secretion, Storage, and Cellular Signaling
    Authors:
    Ewa A.Grzybowska
    Academic press:
    Biomolecules (rok: 2018, tom: 8(2);42, strony: -), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom8020042 - link to the publication
  9. RNA–protein interactions: disorder, moonlighting and junk contribute to eukaryotic complexity
    Authors:
    Anna Balcerak , Alicja Trebinska-Stryjewska , Ryszard Konopinski , Maciej Wakula and Ewa Anna Grzybowska
    Academic press:
    Open Biology (rok: 2019, tom: 9, strony: Open Biol. 9: 190096), Wydawca: The Royal Society Publishing
    Status:
    Published
    DOI:
    10.1098/rsob.190096 - link to the publication
  10. CTC clusters in cancer progression and metastasis
    Authors:
    Fabisiewicz A., Grzybowska E
    Academic press:
    Medical Oncology (rok: 2017, tom: 1,425, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12032-016-0875-0 - link to the publication

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