Projects funded by the NCN
Studies on the synthesis of newly discovered cyclic N6-threonylcarbamoyladenosine (ct6A) and its analogues and on the introduction of ct6A into oligoribonucleotide chain
2014/13/N/ST5/01591
Keywords:
modified tRNA nucleosides cyclic N6-threonylcarbamoyladenosine N6-threonylcarbamoyladenosine (t6A) modified oligoribonucleotides anticodon steam loop (ASL) oxazolone
Descriptors:
- ST5_16:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Politechnika Łódzka, Wydział Chemiczny
woj. łódzkie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 7 - announced on 2014-03-17
Amount awarded: 99 600 PLN
Project start date (Y-m-d): 2015-02-18
Project end date (Y-m-d): 2017-02-17
Project duration:: 24 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Semi-preparatywna kolumna HPLC (Waters) (6 000 PLN)
Information in the final report
- Publication in academic press/journals (3)
- Identification of 2-methylthio cyclic N6-threonylcarbamoyladenosine (ms2ct6A) as a novel RNA modification at position 37 of tRNAsAuthors:Byeong-il Kang, Kenjyo Miyauchi, Michal Matuszewski, Gabriel Silveira, D'Almeida, Mary Anne T. Rubio, Juan D. Alfonzo, Kazuki Inoue, Yuriko Sakaguchi, Takeo Suzuki, Elzbieta Sochacka, Tsutomu SuzukiAcademic press:Nucleic Acids Research (rok: 2017, tom: 45(4), strony: 2124-2136), Wydawca: Oxford University PressStatus:PublishedDOI:10.1093/nar/gkw1120 - link to the publication
- Efficient conversion of N6-threonylcarbamoyladenosine (t6A) into a tRNA native hydantoin cyclic form (ct6A) performed at nucleoside and oligoribonucleotide levelsAuthors:Michał Matuszewski, Katarzyna Dębiec, Elżbieta SochackaAcademic press:Chemical Communications (rok: 2017, tom: 53(56), strony: 7945-794), Wydawca: Royal Society of ChemistryStatus:PublishedDOI:10.1039/C7CC03560H - link to the publication
- A hydantoin isoform of cyclic N6-threonylcarbamoyladenosine (ct6A) is present in tRNAsAuthors:Michal Matuszewski, Jakub Wojciechowski, Kenjyo Miyauchi, Zofia Gdaniec, Wojciech M. Wolf, Tsutomu Suzuki, Elzbieta SochackaAcademic press:Nucleic Acids Research (rok: 2017, tom: 45(4), strony: 2137-2149), Wydawca: Oxford University PressStatus:PublishedDOI:10.1093/nar/gkw1189 - link to the publication