Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Shear stress connected with the fluid flow as an important parameter influencing the adhesion, invasion and tissue tropism of the uropathogenic E. coli producing Dr and Afa-III polyadhesins to the host cells

2014/13/B/NZ6/00257

Keywords:

uropathogenic E. coli urinary tract infections shear stress Dr fimbriae Afa adhesive sheath bacterial tropism

Descriptors:

  • NZ6_4: Bacteriology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Politechnika Gdańska, Wydział Chemiczny

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Rafał Piątek 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 622 200 PLN

Project start date (Y-m-d): 2015-02-09

Project end date (Y-m-d): 2018-02-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Modernizacja odwróconego mikroskopu fluorescencyjnego. (200 000 PLN)
  2. Obiektyw do mikroskopu fluorescencyjnego o powiększeniu 60x oraz adapter kamery kolorowej mikroskopu fluorescencyjnego (16 468 PLN)
  3. Fluorescencyjny mikroskop odwrócony.
  4. Pompa strzykawkowa (40 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. A shear stress micromodel of urinary tract infection by the Escherichia coli producing Dr adhesin
    Authors:
    Beata Zalewska-Piątek, Marcin Olszewski, Tomasz Lipniacki, Sławomir Błoński, Miłosz Wieczór, Piotr Bruździak, Anna Skwarska, Bogdan Nowicki, Stella Nowicki, Rafał Piątek
    Academic press:
    PLOS Pathogens (rok: 2020, tom: 16(1): e1008247, strony: 11689), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.ppat.1008247 - link to the publication
  2. Role of the disulfide bond in stabilizing and folding of the fimbrial protein DraE from uropathogenic Escherichia coli.
    Authors:
    Pilipczuk J, Zalewska-Piątek B, Bruździak P, Czub J, Wieczór M, Olszewski M, Wanarska M, Nowicki B, Augustin-Nowacka D, Piątek R.
    Academic press:
    Journal of Biological Chemistry (rok: 2017, tom: 292, strony: 16136-16149), Wydawca: American Society for Biochemistry and Molecular Biology, ASBMB
    Status:
    Published
    DOI:
    10.1074/jbc.M117.785477. - link to the publication
  3. Alternative treatment approaches of urinary tract infections caused by uropathogenic Escherichia coli strains
    Authors:
    Zalewska-Piątek BM, Piątek RJ.
    Academic press:
    Acta Biochimica Polonica (rok: 2019, tom: 66(2), strony: 129-138), Wydawca: Polish Biochemical Society
    Status:
    Accepted for publication
    DOI:
    10.18388/abp.2018_2787 - link to the publication

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