Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Cholesterol Hydroperoxides - Impaired Steroidogenesis Under Oxidative Stress

2014/13/B/NZ3/00833

Keywords:

oxidative stress lipid peroxidation cholesterol StAR transport proteins steroid hormones

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_4: Ageing
  • NZ1_2: Biochemistry

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Witold Korytowski 

Number of co-investigators in the project: 4

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 846 000 PLN

Project start date (Y-m-d): 2015-03-05

Project end date (Y-m-d): 2018-03-04

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (9)
  • Articles in post-conference publications (1)
  1. Pathophysiological potential of lipid hydroperoxide intermembrane translocation: Cholesterol hydroperoxide translocation as a special case
    Authors:
    Albert W. Girotti and Witold Korytowski
    Academic press:
    Redox Biology (rok: 2021, tom: 46, strony: *), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.10116/j.redox.2021.102096 - link to the publication
  2. Bystander effects of nitric oxide in anti-tumor photodynamic therapy
    Authors:
    Jerzy Bazak, JM. Fahey, Katarzyna Wawak, Witold Korytowski, AW. Girotti
    Academic press:
    Cancer Cell Microenvironment (rok: 2017, tom: 4, strony: 45301), Wydawca: Smart Science & Technology LLC.
    Status:
    Published
    DOI:
    10.14800/ccm.1511. - link to the publication
  3. Cholesterol Peroxidation as a Special Type of Lipid Oxidation in Photodynamic Sysstems
    Authors:
    Girotti AW, Korytowski W
    Academic press:
    Photochemistry and Photobiology (rok: 2019, tom: 95, strony: 73-82), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1111/php.12969 - link to the publication
  4. Multiple Means by Which Nitric Oxide can Antagonize Photodynamic Therapy
    Authors:
    Albert W. Girotti, Jonathan M. Fahey, Witold Korytowski
    Academic press:
    Current Medicinal Chemistry (rok: 2016, tom: 23, strony: 2754-2769), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867323666160812145641 - link to the publication
  5. Anti-Steroidogenic Effects of Cholesterol Hydroperoxide Trafficking in MA-10 Leydig Cells: Role of Mitochondrial Lipid Peroxidation and Mitigation Thereof by Selenoperoxidase GPx4
    Authors:
    Pabisz, P., Bazak, J., Girotti, A. W., and Korytowski, W.
    Academic press:
    Biochemical Biophysical Research Communication (rok: 2021, tom: *, strony: ***), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    doi:101016/j.bbrc.2021.12.117 - link to the publication
  6. Enhanced aggressiveness of bystander cells in an anti-tumor photodynamic therapy model: Role of nitric oxide produced by targeted cells
    Authors:
    Jerzy Bazaka, Jonathan M. Faheyb, Katarzyna Wawaka, Witold Korytowskia,b,⁎, Albert W. Girottib,⁎⁎
    Academic press:
    Free Radical Biology and Medicine (rok: 2017, tom: 102, strony: 111–121), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2016.11.034. - link to the publication
  7. Cholesterol Hydroperoxide Generation, Translocation, and Reductive Turnover in Biological Systems
    Authors:
    AW. Girotti and W. Korytowski
    Academic press:
    Cell Biocemistry and Biophysics (rok: 2017, tom: 75, strony: 413-419), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12013-017-0799-0 - link to the publication
  8. Cholesterol as a natural probe for free radical-mediated lipid peroxidation in biological membranes and lipoproteins
    Authors:
    AW Girotti and W Korytowski
    Academic press:
    Journal of Chromatography B (rok: 2016, tom: 1019, strony: 202-209), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jchromb.2015.12.034 - link to the publication
  9. Intermembrane Translocation of Photodynamically-generated Lipid Hydroperoxide:Broadcasting of Redox Damage
    Authors:
    Albert W Girotti and Witold Korytowski
    Academic press:
    Photochemistry and Photobiology (rok: 2021, tom: *, strony: **), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1111/php.13537 - link to the publication
  1. Cholesterol Hydroperoxide Trafficking: Impairment of Macrophage Cholesterol Efflux with Implications for Atherogenesis under Oxidative Stress
    Authors:
    Korytowski, W; Wawak, K; Pabisz, P; Chadwick, AC; Sahoo, D; Girotti, AW
    Conference:
    Annual Meeting of the American-Society-for-Pharmacology-and-Experimental-Therapeutics (ASPET) at Experimental Biology (rok: 2017, ), Wydawca: FASEB JOURNAL Volume: 31 Supplement: 1
    Data:
    konferencja APR 22-26, 2017
    Status:
    Published

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