Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The role for thiol-dependent antioxidant enzymes in estrogen receptor-positive breast cancer

2014/13/B/NZ5/01354

Keywords:

breast cancer hormone dependence growth factors oxidative stress

Descriptors:

  • NZ3_7: Signal transduction
  • NZ2_9: Systems biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Radosław Zagożdżon 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 213 233 PLN

Project start date (Y-m-d): 2015-01-29

Project end date (Y-m-d): 2018-07-28

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  1. Targeting peroxiredoxin 1 impairs growth of breast cancer cells and potently sensitizes these cells to prooxidant agents
    Authors:
    Malgorzata Bajor, Agata O. Zych, Agnieszka Graczyk-Jarzynka, Angelika Muchowicz, Malgorzata Firczuk, Lech Trzeciak, Pawel Gaj, Antoni Domagala, Marta Siernicka, Agnieszka Zagozdzon, Pawel Siedlecki, Monika Kniotek, Patrick C. O'Leary, Jakub Golab and Radoslaw Zagozdzon
    Academic press:
    British Journal of Cancer (rok: 2018, tom: 7, strony: 873-884), Wydawca: Springer Nature Limited
    Status:
    Published
    DOI:
    10.1038/s41416-018-0263-y - link to the publication
  2. Harnessing altered oxidative metabolism in cancer by augmented prooxidant therapy
    Authors:
    Malgorzata Firczuk, Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Klaudyna Fidyt, Agnieszka Goral, Radoslaw Zagozdzon
    Academic press:
    Cancer Letters (rok: 2020, tom: 471, strony: 45302), Wydawca: ScienceDirect - Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2019.11.037 - link to the publication
  3. Triple combination of ascorbate, menadione and the inhibition of peroxiredoxin-1 produces synergistic cytotoxic effects in triple-negative breast cancer cells
    Authors:
    Malgorzata Bajor, Agnieszka Graczyk-Jarzynka, Katsiaryna Marvelava, Malgorzata Kurkowiak, Arman Rahman, Claudia Aura, Niamh Russell, Agata O. Zych, Malgorzata Firczuk, Magdalena Winiarska,William M. Gallagher, Radoslaw Zagozdzon
    Academic press:
    Antioxidants , Wydawca: MDPI
    Status:
    Submitted
    DOI:
    brak - link to the publication

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