Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Effect of left atrial appendage isolation in patients with atrial fibrillation on coagulation system, fibrinolytic activity and clot permeability. Evaluation and analysis of changes in coagulation parameters in heart chambers.

2014/13/D/NZ5/01351

Keywords:

atrial fibrllilation AF left atrial appendage thrombosis fibrinolysis fibrin clot stroke

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Bartuś 

Number of co-investigators in the project: 2

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 511 664 PLN

Project start date (Y-m-d): 2015-02-12

Project end date (Y-m-d): 2019-02-11

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (10)
  1. A collective European experience with left atrial appendage suture ligation using the LARIAT+ device
    Authors:
    Tilz RR, Fink T, Bartus K, Wong T, Vogler J, Nentwich K, Panniker S, Fang Q, Piorkowski C, Liosis S, Gaspar T, Sawan N, Metzner A, Nietlispach F, Maisano F, Lee RJ, Foran JP, Ouyang F, Sievert H, Deneke T, Kuck KH
    Academic press:
    EP Europace (rok: 2020, tom: 22, strony: 924-931), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/europace/euaa004 - link to the publication
  2. Long-term effect of anticoagulation following left atrial appendage occlusion with the LARIAT device in patients with nonvalvular atrial fibrillation: impact on thromboembolism, bleeding and mortality. Real life data
    Authors:
    Krzysztof Bartus, Grzegoz Filip, Radoslaw Litwinowicz; Dhanunjaya Lakkireddy; Jacek Myc; Magdalena Bartus; Boguslaw Kapelak;
    Academic press:
    Advances in Interventional Cardiology (rok: 2020, tom: 1, strony: 89-96), Wydawca: Termendia
    Status:
    Published
    DOI:
    10.5114/aic.2020.93916 - link to the publication
  3. Rapid left atrial appendage thrombus formation before suture ligation with LARIAT
    Authors:
    K Bartuś, J Myć, M Bartuś, RJ Lee, R Litwinowicz, A Dziewierz, B Kapelak
    Academic press:
    Advances in Interventional Cardiology (rok: 2018, tom: 14, strony: 435–437), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/aic.2018.79876 - link to the publication
  4. Reduction in risk of stroke and bleeding after left atrial appendage closure with Lariat device in patients with increased risk of stroke and bleeding - long term results
    Authors:
    Radoslaw Litwinowicz; Magdalena Bartus, Boguslaw Kapelak; Piotr Suwalski; Dhanunjaya Lakkireddy, Randall J. Lee, Krzysztof Bartus
    Academic press:
    Catheterization and Cardiovascular Interventions (rok: 2019, tom: 94, strony: 837-842), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/ccd.28187 - link to the publication
  5. Left atrial appendage occlusion for stroke prevention in diabetes mellitus patients with atrial fibrillation: long-term results
    Authors:
    Radoslaw Litwinowicz, Magdalena Bartus, Piotr Ceranowicz, Maciej Brzezinski, Bogusław Kapelak, Dhanunjaya Lakkireddy, Krzysztof Bartus
    Academic press:
    Journal of Diabetes (rok: 2018, tom: 11, strony: 75-82), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/1753-0407.12824 - link to the publication
  6. Stroke risk reduction after LAA occlusion in elderly patients with atrial fibrillation- long term results.
    Authors:
    Radoslaw Litwinowicz, Magdalena Bartus, Piotr Ceranowicz, Bogusław Kapelak, Dhanunjaya Lakkireddy , Krzysztof Bartuś
    Academic press:
    Polish Archives of Internal Medicine (rok: 2018, tom: 128, strony: 128(5):327-329), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.4264 - link to the publication
  7. Coagulation factors and fibrinolytic activity in the left atrial appendage and other heart chambers in patients with atrial fibrillation: is there a local intracardiac prothrombotic state? (HEART-CLOT study)
    Authors:
    Krzysztof Bartus, Radoslaw Litwinowicz, Boguslaw Kapelak, Joanna Natorska, Anetta Undas, Michal Zabczyk, Dhanunjaya Lakkireddy, Randall J Lee
    Academic press:
    International Journal of Cardiology (rok: 2020, tom: 301, strony: 103-107), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijcard.2019.09.053 - link to the publication
  8. Left atrial appendage occlusion for secondary stroke prevention in patients with atrial fibrillation: long-term results
    Authors:
    Radoslaw Litwinowicz, Magdalena Bartus, Michalina Malec- Litwinowicz, Michał Michalski, Krzysztof Banaszkiewicz, Bogusław Kapelak, Dhanunjaya Lakkireddy; Krzysztof Bartus,
    Academic press:
    Cerebrovascular Disease (rok: 2019, tom: 47, strony: 188-195), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000500850 - link to the publication
  9. Long term outcomes after left atrial appendage closure with the LARIAT device—Stroke risk reduction over five years follow-up
    Authors:
    Radoslaw Litwinowicz, Magdalena Bartus, Marian Burysz, Maciej Brzeziński, Piotr Suwalski, Boguslaw Kapelak, Venkat Vuddanda, Dhanunjaya Lakkireddy, Randall J Lee, Rafal Trabka, Krzysztof Bartus
    Academic press:
    PLoS One (rok: 2018, tom: 13(12):e020871, strony: 13(12):e020871), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0208710 - link to the publication
  10. Long‐term clinical outcomes from real‐world experience of left atrial appendage exclusion with LARIAT device
    Authors:
    Valay Parikh, Krzysztof Bartus, Radoslaw Litwinowicz, Mohit K Turagam, Jerzy Sadowski, Boguslaw Kapelak, Magdalena Bartus, Jakub Podolec, Maciej Brzezinski, Dan Musat, Abdi Rasekh, Suneet Mittal, Jie Cheng, Nitish Badhwar, Randall Lee, Dhanunjaya Lakkireddy
    Academic press:
    Journal of cardiovascular electrophysiology (rok: 2019, tom: 30, strony: 2849-2857), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/jce.14229 - link to the publication

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