Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The search for neurobiological substrate of susceptibility to kindling of seizures in a model of epilepsy.

2014/13/B/NZ7/02277

Keywords:

different susceptibility to kindling of seizures rats mechanisms of epileptogenesis

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Janusz Szyndler 

Number of co-investigators in the project: 3

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 682 605 PLN

Project start date (Y-m-d): 2015-02-04

Project end date (Y-m-d): 2019-08-03

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pakiet MS Office.
  2. System do mikrodializ OUN u zwierząt (in vivo) (135 000 PLN)
  3. System do stymulacji elektrycznej struktur mózgu oraz rejestracji EEG. (95 400 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (1)
  1. Altered expression of GABA-A receptor subunits in the hippocampus of PTZ-kindled rats.
    Authors:
    Szyndler Janusz, Maciejak Piotr, Kołosowska Karolina, Chmielewska Natalia, Skórzewska Anna, Daszczuk Patrycja, Płaźnik Adam
    Academic press:
    Pharmacological Reports (rok: 2018, tom: 70(1), strony: 14-21), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2017.07.008. - link to the publication
  2. Looking for novel, brain-derived, peripheral biomarkers of neurological disorders
    Authors:
    Natalia Chmielewska, Janusz Szyndler, Karolina Makowska, Dawid Wojtyna, Piotr Maciejak, Adam Płaźnik
    Academic press:
    Polish Journal of Neurology and Neurosurgery (rok: 2018, tom: 52 (3), strony: 318-325), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pjnns.2018.02.002 - link to the publication
  3. Pro‑inflammatory cytokines, but not brain‑ and extracellular matrix‑derived proteins, are increased in the plasma following electrically induced kindling of seizures
    Authors:
    Natalia Chmielewska Piotr Maciejak Bartosz Osuch Miron B. Kursa Janusz Szyndler
    Academic press:
    Pharmacological Reports (rok: 2020, tom: -, strony: -), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s43440-020-00208-w - link to the publication
  4. The role of REST/NRSF, TrkB and BDNF in neurobiological mechanisms of different susceptibility to seizure in a PTZ model of temporal lobe epilepsy
    Authors:
    Chmielewska N, Wawer A, Maciejak P, Turzyńska D, Sobolewska A, Skórzewska A, Osuch B, Płaźnik A, Szyndler J
    Academic press:
    Brain Research Bulletin (rok: 2020, tom: 158, strony: 108-115), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.brainresbull.2020.03.007 - link to the publication
  5. Transcriptional Dysregulation in Huntington's Disease. The Role in Pathogenesis and Potency for Pharmacological Targeting
    Authors:
    Aleksandra Pogoda, Natalia Chmielewska, Piotr Maciejak and Janusz Szyndler
    Academic press:
    Current Medicinal Chemistry (rok: 2020, tom: 27, strony: 45315), Wydawca: BenthamScience
    Status:
    Published
    DOI:
    10.2174/0929867327666200705225821 - link to the publication
  6. Epigenetic mechanisms of stress and depression.
    Authors:
    Natalia Chmielewska, Janusz Szyndler, Piotr Maciejak, Adam Płaźnik
    Academic press:
    Psychiatria Polska (rok: 2019, tom: 53, strony: 1413-1428), Wydawca: Polish Psychiatric Association Editorial/Publishing Commitee
    Status:
    Published
    DOI:
    10.12740/PP/94375 - link to the publication
  7. The role of UCH-L1, MMP-9, and GFAP as peripheral markers of different susceptibility to seizure development in a preclinical model of epilepsy
    Authors:
    Chmielewska Natalia, Maciejak Piotr, Turzyńska Danuta, Sobolewska Alicja, Wisłowska-Stanek Aleksandra, Kołosowska Karolina, Płaźnik Adam, Szyndler Janusz
    Academic press:
    Journal of Neuroimmunology (rok: 2019, tom: 15, strony: 57-63), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2019.03.018 - link to the publication
  1. The interaction between fatty acids and tryptophan in the efficacy of a ketogenic diet in controlling seizure activity
    Authors:
    Piotr Maciejak, Janusz Szyndler, DanutaTurzyńska, Alicja Sobolewska, Karolina Kołosowska, Paweł Krząścik, Adam Płaźnik
    Conference:
    XIX International Congress of the Polish Pharmacological Society (rok: 2015, ), Wydawca: Elsevier
    Data:
    konferencja 17-19.09
    Status:
    Published

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