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Studies on the stereoselective 1,3-Dipolar cycloaddition reactions of cyclic nitrones with alpha, beta - unsaturated lactones. Synthesis of carbapenams and carbapenems.

2014/13/N/ST5/01758

Keywords:

1,3-dipolar cycloaddition diastereoselective reactions beta-lactamic compounds antibiotics

Descriptors:

  • ST5_23:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Organicznej PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Michał Pieczykolan 

Number of co-investigators in the project: 2

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 97 500 PLN

Project start date (Y-m-d): 2015-01-27

Project end date (Y-m-d): 2017-01-26

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  1. Formal synthesis of Thienamycin
    Authors:
    M. Pieczykolan, B. Furman, M. Chmielewski
    Academic press:
    The Journal of Antibiotics (rok: 2017, tom: 70, strony: 781-787), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/ja.2017.44 - link to the publication
  2. 1,3-Dipolar cycloaddition of a cyclic nitrone derived from 2-deoxy-D-ribose to α,β-unsaturated lactones: An entry to carbapenem antibiotics
    Authors:
    M. Pieczykolan, O. Staszewska-Krajewska, B. Furman, M. Chmielewski
    Academic press:
    Carbohydrate Research (rok: 2016, tom: 433, strony: 89-96), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.carres.2016.07.002 - link to the publication