Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Dysregulation of miRNA molecules responsible for maturation of oligodendrocyte precursor cells/progenitors (OPCs) as a key element of impaired remyelination in multiple sclerosis

2014/13/B/NZ6/00235

Keywords:

multiple sclerosis oligodendrocyte precursor cell/progenitor miRNA

Descriptors:

  • NZ3_6: Cell neurobiology
  • NZ5_3: Pathogenesis of human diseases
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Lekarski

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Przemysław Lewkowicz 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 907 900 PLN

Project start date (Y-m-d): 2015-01-23

Project end date (Y-m-d): 2019-01-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komora laminarna (44 000 PLN)
  2. zestaw do ilościowego oznaczania transkryptu (digital PCR) QX200, współfinansowanie.
  3. Biurowe urządzenie wielofuncyjne Kyocera M2540.
  4. Doposażenie mikroskopu contrastowo-fazowego Zeiss Axiovert 200 w moduł do analizy konfokalnej i obserwacji hodowli w czasie rzeczywistym (100 000 PLN)
  5. Komputer osobisty typu notebook (6 000 PLN)
  6. drukarka Kyocera P2040.

Information in the final report

  • Publication in academic press/journals (3)
  1. MS CD49d+CD154+ Lymphocytes Reprogram Oligodendrocytes into Immune Reactive Cells Affecting CNS Regeneration
    Authors:
    Piatek P, Namiecinska M, Domowicz M, Przygodzka P, Wieczorek M, Michlewska S, Lewkowicz N, Tarkowski M and Lewkowicz P
    Academic press:
    Cells (rok: 2019, tom: 25, strony: 1508), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8121508 - link to the publication
  2. Dysregulated RNA-Induced Silencing Complex (RISC) Assembly within CNS Corresponds with Abnormal miRNA Expression during Autoimmune Demyelination
    Authors:
    Lewkowicz P, Cwiklińska H, Mycko MP, Cichalewska M, Domowicz M, Lewkowicz N, Jurewicz A, Selmaj KW
    Academic press:
    Journal Neuroscience (rok: 2015, tom: 13; 35, strony: 7521-37), Wydawca: Stanford University's HighWire Press®
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.4794-14.2015 - link to the publication
  3. Multiple Sclerosis CD49d+CD154+ As Myelin-Specific Lymphocytes Induced During Remyelination
    Authors:
    Paweł Piatek , Magdalena Namiecinska, Małgorzata Domowicz, Marek Wieczorek, Sylwia Michlewska, Mariola Matysiak, Natalia Lewkowicz, Maciej Tarkowski and Przemysław Lewkowicz
    Academic press:
    Cells (rok: 2020, tom: 9, strony: 15), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells9010015 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy