Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Physicochemical characterization of cyclodextrins tailored for pH-dependent targeted therapy with anthracycline drugs

2014/13/B/ST5/04117

Keywords:

anthracycline cyclodextrins targeted therapy

Descriptors:

  • ST5_12: Methods of nanomaterials/materials synthesis
  • ST5_22:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Warszawski, Wydział Chemii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Renata Bilewicz 

Number of co-investigators in the project: 6

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 828 350 PLN

Project start date (Y-m-d): 2015-01-26

Project end date (Y-m-d): 2018-05-25

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Spektrometr Agilent Cary 60 + Termostatowany podajnik do kuwet (50 000 PLN)
  2. Suszarka próżniowa VT6025 (30 000 PLN)
  3. Wyparka rotacyjna z systemem próżniowym (30 000 PLN)
  4. Zestaw komputerowy (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Book publications / chapters in book publications (1)
  1. Complexing daunorubicin with β-cyclodextrin derivative increases drug intercalation into DNA
    Authors:
    Agata Krzak, Olga Swiech, Maciej Majdecki, Renata Bilewicz
    Academic press:
    Electrochimica Acta (rok: 2017, tom: 247, strony: 139-148), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.electacta.2017.06.140 - link to the publication
  2. Doxorubicin carriers based on Au nanoparticles – effect of shape and gold-drug linker on the carrier toxicity and therapeutic performance
    Authors:
    Olga A. Swiech, Lidia J. Opuchlik, Grzegorz Wojciuk, Tomasz M. Stepkowski, Marcin Kruszewski, Renata Bilewicz.
    Academic press:
    RSC Advances (rok: 2016, tom: 6, strony: 31960-31967), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6RA00177G - link to the publication
  3. The impact of medium pH on the mechanism of DOX interaction with HeLa and A498 cell lines
    Authors:
    Alicja Trebinska-Stryjewska, Lidia Jagoda Opuchlik, Ewa Grzybowska, Maciej Majdecki, Renata Bilewicz, Olga Angelika Swiech
    Academic press:
    PLOS ONE , Wydawca: Public Library of Science
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. Competition between self-inclusion and drug binding explains the pH dependence of cyclodextrin drug carrier - molecular modelling and electrochemistry studies.
    Authors:
    Olga Święch, Maciej Majdecki, Aleksander Dębiński, Agata Krzak, Tomasz Maciej Stępkowski, Grzegorz Wójciuk, Marcin Kruszewski, Ranata Bilewicz
    Academic press:
    Nanoscale (rok: 2016, tom: 8, strony: 16733–16742), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C6NR05833G - link to the publication
  5. Towards potent but less toxic nanopharmaceuticals – lipoic acid bioconjugates of ultrasmall gold nanoparticles with an anticancer drug and addressing unit
    Authors:
    Maciej Dzwonek, Dominika Załubiniak, Piotr Piątek, Grzegorz Cichowicz, Sylwia Męczynska-Wielgosz, Tomasz Stępkowski, Marcin Kruszewski, Agnieszka Więckowska, Renata Bilewicz
    Academic press:
    RSC Advances (rok: 2018, tom: 8, strony: 14947-14957), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c8ra01107a - link to the publication
  1. Badania trwałości kompleksów inkluzyjnych modyfikowanych cyklodekstryn z lekami antrachinonowymi
    Authors:
    Agata Krzak, Olga Święch, Maciej Majdecki, Renata Bilewicz
    Book:
    Współczesne metody i sensory elektrochemiczne (rok: 2018, tom: brak, strony: 275-282), Wydawca: Wydawnictwo Naukowe AKAPIT, ISBN 978-83-65955-09-8
    Status:
    Published

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