Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Neurochemical properties and biological activity of synthetic cathinones (beta-ketoamphetamines) - the psychostimulant "legal highs"

2014/13/B/NZ7/02237

Keywords:

novel psychoactive substances designer cathinones cytotoxicity genotoxicity astrocytes activity gene expression dopamine noradrenaline serotonin

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny w Łodzi, Wydział Farmaceutyczny

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jolanta Zawilska 

Number of co-investigators in the project: 7

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 571 890 PLN

Project start date (Y-m-d): 2015-02-18

Project end date (Y-m-d): 2018-12-17

Project duration:: 46 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zestaw do pomiaru aktywności ruchowej Model Opto-Varimes 4. Producent Columbus Instruments, USA. (110 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (1)
  1. Next generation of novel psychoactive substances on the horizon - A complex problem to face
    Authors:
    Jolanta B. Zawilska, Dariusz Andrzejczak
    Academic press:
    Drug and Alcohol Dependence (rok: 2015, tom: 157, strony: 45308), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.drugalcdep.2015.09.030 - link to the publication
  2. An expanding world of novel psychoactive substances: Opioids
    Authors:
    Jolanta B. Zawilska
    Academic press:
    Frontiers in Psychiatry (rok: 2017, tom: 8, strony: 45305), Wydawca: www.frontiersin.org
    Status:
    Published
    DOI:
    10.3389/fpsyt.2017.00110 - link to the publication
  3. Cytotoxic activity of pyrovalerone derivatives, an emerging group of psychostimulant designer cathinones
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Agata Woldan-Tambor, Jolanta B. Zawilska
    Academic press:
    Neurotoxicity Research (rok: 2016, tom: 30, strony: 239-250), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-016-9640-6 - link to the publication
  4. JWH-133, a selective cannabinoid CB2 receptor agonist, exerts toxic effects on neuroblastoma SH-SY5Y cells.
    Authors:
    Jakub Wojcieszak, Wojciech Krzemień, Jolanta B. Zawilska
    Academic press:
    Journal of Molecular Neuroscience (rok: 2016, tom: 58, strony: 441-445), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12031-016-0726-7 - link to the publication
  5. Comparative neuropharmacological studies on three pyrrolidine-containing synthetic cathinones
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Adam Wojtas, Krystyna Gołembiowska, Jolanta B. Zawilska
    Academic press:
    Forensic Toxicology (rok: 2020, ), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s11419-020-00523-0 - link to the publication
  6. Induction of immediate early genes expression in the mouse striatum following acute administration of synthetic cathinones
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Bożena Szymańska, Jolanta B. Zawilska
    Academic press:
    Pharmacological Reports (rok: 2019, tom: 71, strony: 977-982), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharrep.2019.05.011 - link to the publication
  7. Methcathinone and 3-fluoromethcathinone stimulate spontaneous horizontal locomotor activity in mice and elevate extracellular dopamine and serotonin levels in the mouse striatum
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Adam Wojtas, Krystyna Gołembiowska, Jolanta B. Zawilska
    Academic press:
    Neurotoxicity Research (rok: 2019, tom: 35, strony: 594-605), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-018-9973-4 - link to the publication
  8. alpha-Pyrrolidinophenones: a new wave of designer cathinones
    Authors:
    Jolanta B. Zawilska, Jakub Wojcieszak
    Academic press:
    Forensic Toxicology (rok: 2017, tom: 35, strony: 201-216), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11419-016-0353-6 - link to the publication
  9. Cytotoxicity of alpha-pyrrolidinophenones: an impact of alpha-aliphatic side-chain lenght and changes in the plasma membrane fluidity
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Marta Kedzierska, Katarzyna Milowska, Jolanta B. Zawilska
    Academic press:
    Neurotoxicity Research (rok: 2018, tom: 34, strony: 613-626), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-018-9923-1 - link to the publication
  10. Effects of the new generation alpha-pyrrolidinophenones on spontaneous locomotor activities in mice, and on extracellular dopamine and serotonin levels in the mouse striatum
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Adam Wojtas, Krystyna Gołembiowska, Jolanta B. Zawilska
    Academic press:
    Forensic Toxicology (rok: 2018, tom: 36, strony: 334-350), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11419-018-0409-x - link to the publication
  1. Evaluation of the impact of six cathinones on the spontaneous locomotor activity in mice
    Authors:
    Jakub Wojcieszak, Dariusz Andrzejczak, Katarzyna Kuczyńska, Jolanta B. Zawilska
    Conference:
    3rd Central European Biomedical Congress. News on biomarker discovery and research innovations in medicine and biomedical sciences (rok: 2018, ), Wydawca: CEBC Cracow 2018, Abstract Book
    Data:
    konferencja 15-18 September
    Status:
    Published
  2. Novel Psychoactive Substances - New Players in the Old Drama
    Authors:
    Jolanta B. Zawilska
    Conference:
    13th European Congress Heroin Addiction & Related Clinical Problems (rok: 2018, ), Wydawca: Pacini Editore Medicina
    Data:
    konferencja 25-27 May
    Status:
    Published
  3. Effects of synthetic cathinones on viability of cortical astrocyte in culture
    Authors:
    Dariusz Andrzejczak, Jakub Wojcieszak, Agata Woldan-Tambor, Irena Matusik, Joanna Próchniewicz, Jolanta B. Zawilska
    Conference:
    3rd Central European Biomedical Congress. News on biomarker discovery and research innovations in medicine and biomedical sciences (rok: 2018, ), Wydawca: CEBC, Cracow 2018 Abstract Book
    Data:
    konferencja 15-18 September
    Status:
    Published
  1. Novel Psychoactive Substances: Classification and General Information
    Authors:
    Jolanta B. Zawilska, Jakub Wojcieszak
    Book:
    Synthetic Cathinones. Novel Addictive and Stimulatory Psychoactive Substances. Current Topics in Neurotoxitology (rok: 2018, tom: 12, strony: 45620), Wydawca: Springer International Publishing AG
    Status:
    Published

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