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Contribution of iron status to immune response and myocardial remodeling in patients with myocarditis and post-myocarditis non-ischaemic dilated cardiomyopathy

2014/13/B/NZ5/03146

Keywords:

myocarditis post-myocarditis dilated cardiomyopathy iron deficiency heart failure

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Nauk o Zdrowiu

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Jankowska 

Number of co-investigators in the project: 9

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 1 890 681 PLN

Project start date (Y-m-d): 2015-02-18

Project end date (Y-m-d): 2019-02-17

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (12)
  1. Primary Human Cardiomyocytes and Cardiofibroblasts Treated with Sera from Myocarditis Patients Exhibit an Increased Iron Demand and Complex Changes in the Gene Expression
    Authors:
    Kamil A Kobak, Paweł Franczuk , Justyna Schubert, Magdalena Dzięgała, Monika Kasztura, Michał Tkaczyszyn, Marcin Drozd, Aneta Kosiorek, Liliana Kiczak, Jacek Bania, Piotr Ponikowski, Ewa A Jankowska
    Academic press:
    Cells (rok: 2021, tom: 10(4):818, strony: 45307), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cells10040818 - link to the publication
  2. Structural and functional abnormalities in iron-depleted heart
    Authors:
    Kamil A Kobak, Malwina Radwańska, Magdalena Dzięgała, Monika Kasztura, Krystian Josiak, Waldemar Banasiak, Piotr Ponikowski, Ewa A Jankowska
    Academic press:
    Heart Failure Reviews (rok: 2019, tom: 24, strony: 269–277), Wydawca: Springer US
    Status:
    Published
    DOI:
    10.1007/s10741-018-9738-4 - link to the publication
  3. Iron deficiency contributes to resistance to endogenous erythropoietin in anaemic heart failure patients
    Authors:
    Michał Tkaczyszyn, Josep Comín-Colet, Adriaan A Voors, Dirk J van Veldhuisen, Cristina Enjuanes, Pedro Moliner, Marcin Drozd, Radosław Sierpiński, Piotr Rozentryt, Jolanta Nowak, Tomasz Suchocki, Waldemar Banasiak, Piotr Ponikowski, Peter van der Meer, Ewa A Jankowska
    Academic press:
    European Journal of Heart Failure (rok: 2021, tom: 10, strony: 1677-1686), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ejhf.2253 - link to the publication
  4. Monitoring of iron status in patients with heart failure
    Authors:
    Ewa A. Jankowska, Michał Tkaczyszyn, Marcin Drozd, Piotr Ponikowski1
    Academic press:
    European Heart Journal Supplements (rok: 2019, tom: 21, strony: M32–M35), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/eurheartj/suz231 - link to the publication
  5. Drug therapy in elderly heart failure patients
    Authors:
    Ewa A Jankowska, Cristiana Vitale, Izabella Uchmanowicz, Michał Tkaczyszyn, Marcin Drozd, Piotr Ponikowski
    Academic press:
    European Heart Journal Supplements (rok: 2019, tom: 21, strony: L8–L11), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/eurheartj/suz237 - link to the publication
  1. Determinants of iron deficiency in younger versus older patients with heart failure
    Authors:
    M. Drozd, M. Kasztura, K. Wegrzynowska, P. Rozentryt, J. Nowak, L. Polonski, J. Malyszko, E. Koc-Zorawska, W. Banasiak, P. Ponikowski, E.A. Jankowska
    Conference:
    ESC Congress 2017, 26-30 August, Barcelona, Spain (rok: 2017, ), Wydawca: OXFORD UNIV PRESS
    Data:
    konferencja 26-30.08.2017
    Status:
    Published
    DOI:
    link to the publication
  2. Iron status in patients with heart failure with reduced ejection fraction with ischaemic versus non-ischaemic aetiology.
    Authors:
    M Drozd, M Kasztura, P Rozentryt, J Nowak, L Polonski, J Malyszko, E Koc-Zorawska, W Banasiak, P Ponikowski , EA Jankowska
    Conference:
    Heart Failure 2016 (rok: 2016, ), Wydawca: WILEY-BLACKWELL
    Data:
    konferencja 21-24.05.2016
    Status:
    Published
  3. Sera from myocarditis patients caused iron depletion in cultured human cardiomyocytes
    Authors:
    K A. Kobak , J. Schubert , M. Dziegala , M. Kasztura , P. Franczuk , M. Drozd , K. Kulej-Lyko , J. Bania , P. Ponikowski , EA. Jankowska
    Conference:
    Heart Failure Winter Research Meeting 2019, Les Diablerets, Switzerland (rok: 2019, ), Wydawca: xxx
    Data:
    konferencja 23 - 26 January 2019
    Status:
    Accepted for publication
  4. Contribution of iron status to malfunctioning of human cardiomyocytes and cardiofibroblasts in the course of myocarditis
    Authors:
    K A Kobak, M Dziegala, P Franczuk, M Kasztura, M Tkaczyszyn, M Drozd, K Josiak, N Sidorowicz, P Gac, L Kiczak, J Bania, W Banasiak, P Ponikowski, EA Jankowska
    Conference:
    Heart Failure 2018 and the World Congress on Acute Heart Failure, Vienna, Austria (rok: 2018, ), Wydawca: WILEY
    Data:
    konferencja 26-29 May 2018
    Status:
    Published
  5. How does diabetes affect iron status in patients with heart failure?
    Authors:
    M. Drozd, M. Kasztura, K. Wegrzynowska, P. Rozentryt, J. Nowak, L. Polonski, J. Malyszko, E. Koc-Zorawska, W. Banasiak, P. Ponikowski, E.A. Jankowska
    Conference:
    ESC Congress 2017, 26-30 August, Barcelona, Spain (rok: 2017, ), Wydawca: OXFORD UNIV PRESS
    Data:
    konferencja 26-30.08.2017
    Status:
    Published
    DOI:
    link to the publication
  6. Iron deficiency relates to neurohormonal activation in acute myocarditis
    Authors:
    P[aweł] Franczuk, K[atarzyna] Kulej-Lyko, M[arcin] Drozd, M[ichał] Tkaczyszyn, N. Sidorowicz, I[rena] Flinta, P[aweł] Gać, W[aldemar] Banasiak, P[iotr] Ponikowski, Ewa A[nita] Jankowska
    Conference:
    Heart Failure 2018 and the World Congress on Acute Heart Failure, Vienna, Austria (rok: 2018, ), Wydawca: WILEY
    Data:
    konferencja 26-29 May 2018
    Status:
    Published
  7. Biomarkers of iron status (transferrin saturation, serum ferritin) in the course of acute myocarditis: relations with neurohormonal activation, cardiac dysfunction and clinical recovery
    Authors:
    P. Franczuk, A. Kosiorek, M. Tkaczyszyn, M. Drozd, A. Zapolska, T. Walczak, K. Kulej-Lyko, N. Sidorowicz, A. Soltowska, W. Banasiak, J. Jaroch, P. Ponikowski, EA. Jankowska
    Conference:
    Heart Failure 2019 - 6th World Congress on Acute Heart Failure, Ateny, Grecja (rok: 2019, ), Wydawca: WILEY-BLACKWELL
    Data:
    konferencja 25-28 May 2019
    Status:
    Accepted for publication
  8. High circulating ferritin reflects myocardial injury in cardiac magnetic resonance in patients with acute myocarditis (MCD)
    Authors:
    A. Kosiorek, P. Franczuk, P. Gac, M. Drozd, M. Tkaczyszyn, , T. Walczak, A. Zapolska, K. Kulej-Lyko, N. Sidorowicz, A. Soltowska, J. Jaroch, P. Ponikowski, W. Kosmala, M.Przewocka-Kosmala, EA. Jankowska
    Conference:
    ESC Congress 2019, Paryż, Francja (rok: 2019, ), Wydawca: OXFORD UNIV PRESS
    Data:
    konferencja 31.08-04.09.2019
    Status:
    Accepted for publication
  9. The influence of iron status on the impaired functioning of human cardiofibroblasts and cardiomyocytes in the course of acute phase of myocarditis
    Authors:
    K[amil] A. Kobak, M[agdalena] Dzięgała, P[aweł] Franczuk, M[onika] Kasztura, M[ichał] Tkaczyszyn, M[arcin] Drozd, K[rystian] Josiak, N. Sidorowicz, P[aweł] Gać, L. Kiczak, J. Bania, W. Banasiak, P[iotr] Ponikowski, E[wa] A. Jankowska
    Conference:
    ESC Congress 2018, 25-29 August, Munich, Germany (rok: 2018, ), Wydawca: OXFORD UNIV PRESS
    Data:
    konferencja 25-29.08.2018
    Status:
    Published
    DOI:
    link to the publication
  10. High circulating ferritin predicts oedema and fibrosis assesed in cardiac magnetic resonance in patients with acute myocarditis
    Authors:
    A. Kosiorek, P. Franczuk, P. Gac, M. Drozd, M. Tkaczyszyn, , T. Walczak, A. Zapolska, K. Kulej-Lyko, N. Sidorowicz, A. Soltowska, W. Banasiak, J. Jaroch, P. Ponikowski, EA. Jankowska
    Conference:
    Heart Failure 2019 - 6th World Congress on Acute Heart Failure, Ateny, Grecja (rok: 2019, ), Wydawca: WILEY-BLACKWELL
    Data:
    konferencja 25-28 May 2019
    Status:
    Accepted for publication
  11. Iron depletion in human cardiomyocytes cultured with sera from myocarditis patients
    Authors:
    K A. Kobak , J. Schubert , M. Kasztura , P. Franczuk , M. Dziegala , M. Drozd , M. Tkaczyszyn , K. Kulej-Lyko , J. Bania , W. Banasiak , P. Ponikowski , EA. Jankowska
    Conference:
    ESC Congress 2019, Paryż, Francja (rok: 2019, ), Wydawca: OXFORD UNIV PRESS
    Data:
    konferencja 31.08-04.09.2019
    Status:
    Accepted for publication
  12. HFWM: Sera from myocarditis patients caused iron depletion in cultured human cardiomyocytes
    Authors:
    K A. Kobak, J. Schubert, M. Dziegala, . Kasztura, P. Franczuk, M. Drozd, K. Kulej-Lyko, J. Bania, P. Ponikowski, EA. Jankowska
    Conference:
    Heart Failure 2019 - 6th World Congress on Acute Heart Failure (rok: 2019, ), Wydawca: xxx
    Data:
    konferencja 25-28 May 2019
    Status:
    Accepted for publication

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