Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Cancer stem cells signaling pathways as a therapeutic terget in ovarian cancer chemotherapy

2014/13/B/NZ5/00334

Keywords:

cancer stem cells signaling pathways ovarian cancer chemotherapy resistance

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ3_8: Stem cell biology
  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Zabel 

Number of co-investigators in the project: 5

Call: OPUS 7 - announced on 2014-03-17

Amount awarded: 947 880 PLN

Project start date (Y-m-d): 2015-02-04

Project end date (Y-m-d): 2020-02-03

Project duration:: 60 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2.
  2. Sonikator Bioruptor® Plus (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.
    Authors:
    Januchowski R, Wojtowicz K, Sterzyńska K, Sosińska P, Andrzejewska M, Zawierucha P, Nowicki M, Zabel M.
    Academic press:
    The international journal of biochemistry & cell biology. (rok: 2016, tom: 78, strony: 248-59), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biocel.2016.07.017. - link to the publication
  2. Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines.
    Authors:
    Januchowski R, Sterzyńska K, Zaorska K, Sosińska P, Klejewski A, Brązert M, Nowicki M, Zabel M
    Academic press:
    Journal of Ovarian Research (rok: 2016, tom: 9(1), strony: 65), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13048-016-0278-z - link to the publication
  3. Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines
    Authors:
    Januchowski R, Sterzyńska K, Zawierucha P, Ruciński M, Świerczewska M, Partyka M, Bednarek-Rajewska K, Brązert M, Nowicki M, Zabel M, Klejewski A
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 49944-49958), Wydawca: RAPAMYCIN PRESS
    Status:
    Published
    DOI:
    10.18632/oncotarget.18278. - link to the publication
  4. New and Old Genes Assiociated with Topotecan Resistance Development in Ovarian Cancer Cell Lines
    Authors:
    Andrzej Klejewski, Monika Świerczewska, Katarzyna Zaorska, Maciej Brązert, Michał Nowicki, Maciej Zabel, Radosław Januchowski
    Academic press:
    Anticancer Research (rok: 2017, tom: 37, strony: 1625-1636), Wydawca: INT INST ANTICANCER RESEARCH
    Status:
    Published
    DOI:
    10.21873/anticanres.11493 - link to the publication
  5. PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations.
    Authors:
    Świerczewska M, Sterzyńska K, Wojtowicz K, Kaźmierczak D, Iżycki D, Nowicki M, Zabel M, Januchowski R
    Academic press:
    Internacional Journal of Molecular Sciences (rok: 2019, tom: 20(8), strony: pii: E2053, 17 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20082053. - link to the publication
  6. Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs
    Authors:
    Karolina Wojtowicz, Karolina Sterzyńska, Monika Świerczewska, Michał Nowicki, Maciej Zabel, Radosław Januchowski
    Academic press:
    Internacional Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 22), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084243 - link to the publication
  7. The significance of HERC5, IFIH1, SAMD4, SEMA3A and MCTP1 genes expression in resistance to cytotoxic drugs in ovarian cancer cell lines
    Authors:
    Marta Nowacka, Barbara Ginter-Matuszewska, Monika Świerczewska, Michał Nowicki, Maciej Zabel, Karolina Sterzyńska, Radosław Januchowski
    Academic press:
    Medical Journal of Cell Biology (rok: 2021, tom: 9 (3), strony: 138-147), Wydawca: Sciendo
    Status:
    Published
    DOI:
    10.2478/acb-2021-0019 - link to the publication
  8. New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines
    Authors:
    Monika Świerczewska, Andrzej Klejewski, Maciej Brązert, Dominika Kaźmierczak, Dariusz Iżycki, Michał Nowicki, Maciej Zabel and Radosław Januchowski
    Academic press:
    Molecues (rok: 2018, tom: 23, strony: E891 - 16 stron), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23040891 - link to the publication
  9. The significance of lumican expression in ovarian cancer drug-resistant cell lines
    Authors:
    Klejewski A, Sterzyńska K, Wojtowicz K, Świerczewska M, Partyka M, Brązert M, Nowicki M, Zabel M, Januchowski R
    Academic press:
    Oncotarget (rok: 2017, tom: 8, strony: 74466-74478), Wydawca: RAPAMYCIN PRESS
    Status:
    Published
    DOI:
    10.18632/oncotarget.20169 - link to the publication
  10. Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines.
    Authors:
    Januchowski R, Świerczewska M1, Sterzyńska K, Wojtowicz K, Nowicki M, Zabel M.
    Academic press:
    Journal of Cancer (rok: 2016, tom: 7(10), strony: 1295-310), Wydawca: IVYSPPING
    Status:
    Published
    DOI:
    10.7150/jca.15371. - link to the publication

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