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Cancer stem cells signaling pathways as a therapeutic terget in ovarian cancer chemotherapy

2014/13/B/NZ5/00334

Keywords

Descriptors

  • NZ5_7: Leczenie chorób człowieka
  • NZ3_8: Komórki macierzyste
  • NZ5_3: Patogeneza chorób człowieka

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Medyczny

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Maciej Zabel

Number of co-investigators in the project: 5

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
947 880 PLN
Project start date
2015-02-04
Project end date
2020-02-03
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Inkubator CO2.
  2. Sonikator Bioruptor® Plus. Cost: 80 000 PLN

Information in the final report

Publication in academic press/journals (10)

  1. Piperine Targets Different Drug Resistance Mechanisms in Human Ovarian Cancer Cell Lines Leading to Increased Sensitivity to Cytotoxic Drugs

    Authors:
    Karolina Wojtowicz, Karolina Sterzyńska, Monika Świerczewska, Michał Nowicki, Maciej Zabel, Radosław Januchowski
    Academic press:
    Internacional Journal of Molecular Sciences (year: 2021, volume: 22, pages: 22), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22084243 – link to the publication

  2. The significance of lumican expression in ovarian cancer drug-resistant cell lines

    Authors:
    Klejewski A, Sterzyńska K, Wojtowicz K, Świerczewska M, Partyka M, Brązert M, Nowicki M, Zabel M, Januchowski R
    Academic press:
    Oncotarget (year: 2017, volume: 8, pages: 74466-74478), Publisher: RAPAMYCIN PRESS
    Status:
    Published
    DOI:
    10.18632/oncotarget.20169 – link to the publication

  3. Increased Expression of Several Collagen Genes is Associated with Drug Resistance in Ovarian Cancer Cell Lines.

    Authors:
    Januchowski R, Świerczewska M1, Sterzyńska K, Wojtowicz K, Nowicki M, Zabel M.
    Academic press:
    Journal of Cancer (year: 2016, volume: 7(10), pages: 1295-310), Publisher: IVYSPPING
    Status:
    Published
    DOI:
    10.7150/jca.15371. – link to the publication

  4. New and Old Genes Associated with Primary and Established Responses to Paclitaxel Treatment in Ovarian Cancer Cell Lines

    Authors:
    Monika Świerczewska, Andrzej Klejewski, Maciej Brązert, Dominika Kaźmierczak, Dariusz Iżycki, Michał Nowicki, Maciej Zabel and Radosław Januchowski
    Academic press:
    Molecues (year: 2018, volume: 23, pages: E891 - 16 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules23040891 – link to the publication

  5. Inhibition of ALDH1A1 activity decreases expression of drug transporters and reduces chemotherapy resistance in ovarian cancer cell lines.

    Authors:
    Januchowski R, Wojtowicz K, Sterzyńska K, Sosińska P, Andrzejewska M, Zawierucha P, Nowicki M, Zabel M.
    Academic press:
    The international journal of biochemistry & cell biology. (year: 2016, volume: 78, pages: 248-59), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.biocel.2016.07.017. – link to the publication

  6. Microarray-based detection and expression analysis of new genes associated with drug resistance in ovarian cancer cell lines

    Authors:
    Januchowski R, Sterzyńska K, Zawierucha P, Ruciński M, Świerczewska M, Partyka M, Bednarek-Rajewska K, Brązert M, Nowicki M, Zabel M, Klejewski A
    Academic press:
    Oncotarget (year: 2017, volume: 8, pages: 49944-49958), Publisher: RAPAMYCIN PRESS
    Status:
    Published
    DOI:
    10.18632/oncotarget.18278. – link to the publication

  7. Analysis of MDR genes expression and cross-resistance in eight drug resistant ovarian cancer cell lines.

    Authors:
    Januchowski R, Sterzyńska K, Zaorska K, Sosińska P, Klejewski A, Brązert M, Nowicki M, Zabel M
    Academic press:
    Journal of Ovarian Research (year: 2016, volume: 9(1), pages: 65), Publisher: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13048-016-0278-z – link to the publication

  8. The significance of HERC5, IFIH1, SAMD4, SEMA3A and MCTP1 genes expression in resistance to cytotoxic drugs in ovarian cancer cell lines

    Authors:
    Marta Nowacka, Barbara Ginter-Matuszewska, Monika Świerczewska, Michał Nowicki, Maciej Zabel, Karolina Sterzyńska, Radosław Januchowski
    Academic press:
    Medical Journal of Cell Biology (year: 2021, volume: 9 (3), pages: 138-147), Publisher: Sciendo
    Status:
    Published
    DOI:
    10.2478/acb-2021-0019 – link to the publication

  9. New and Old Genes Assiociated with Topotecan Resistance Development in Ovarian Cancer Cell Lines

    Authors:
    Andrzej Klejewski, Monika Świerczewska, Katarzyna Zaorska, Maciej Brązert, Michał Nowicki, Maciej Zabel, Radosław Januchowski
    Academic press:
    Anticancer Research (year: 2017, volume: 37, pages: 1625-1636), Publisher: INT INST ANTICANCER RESEARCH
    Status:
    Published
    DOI:
    10.21873/anticanres.11493 – link to the publication

  10. PTPRK Expression Is Downregulated in Drug Resistant Ovarian Cancer Cell Lines, and Especially in ALDH1A1 Positive CSCs-Like Populations.

    Authors:
    Świerczewska M, Sterzyńska K, Wojtowicz K, Kaźmierczak D, Iżycki D, Nowicki M, Zabel M, Januchowski R
    Academic press:
    Internacional Journal of Molecular Sciences (year: 2019, volume: 20(8), pages: pii: E2053, 17 stron), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20082053. – link to the publication

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