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Specific aspects of physicochemical phenomena and mass transfer in lung fluids in the presence of inhaled micro- and nanoparticles with complex properties

2014/13/B/ST8/00808

Keywords

Descriptors

  • ST8_1: Inżynieria chemiczna, chemia techniczna, inżynieria środowiska, inżynieria sanitarna, inżynieria procesowa
  • ST5_15: Chemia koloidów
  • NZ1_3: Biofizyka

Panel

ST8 – Production and processes engineering: modelling, product design, process design and control, construction methods and engineering, power units and systems

Host institution

Politechnika Warszawska, Wydział Inżynierii Chemicznej i Procesowej

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Tomasz Robert Sosnowski

Number of co-investigators in the project: 7

Call

OPUS 7 – announced on 2014-03-17

Amount awarded
599 810 PLN
Project start date
2015-02-05
Project end date
2019-01-04
Project duration
47 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Komputer. Cost: 4 500 PLN
  2. Urządzenie do pomiaru dynamicznego napięcia powierzchniowego i kąta zwliżania. Cost: 155 000 PLN
  3. Waga Langmuira-Wilhelmy'ego.

Information in the final report

Publication in academic press/journals (18)

  1. Zmiany ściśliwości powierzchniowej w układzie woda-powietrze zawierającym DPPC i wielościenne nanorurki węglowe

    Authors:
    Dobrowolska Katarzyna, Sosnowski Tomasz R.
    Academic press:
    Inżynieria i Aparatura Chemiczna (year: 2017, volume: 56(4), pages: 114-115), Publisher: Zarząd Główny SIMP
    Status:
    Published
    DOI:
    link to the publication

  2. Particles on the lung surface – physicochemical and hydrodynamic effects

    Authors:
    Sosnowski Tomasz R.
    Academic press:
    Curr. Opin. Colloid Interface Sci. (year: 2018, volume: 36, pages: 46031), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cocis.2017.12.003 – link to the publication

  3. Inhalation devices: from basic science to practical use, innovative vs generic products

    Authors:
    Pirożyński Michał, Sosnowski Tomasz R.
    Academic press:
    Expert Opin. Drug Del. (year: 2016, volume: 13, pages: 1559-1571), Publisher: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/17425247.2016.1198774 – link to the publication

  4. Interactions of insoluble micro- and nanoparticles with the air-liquid interface of the model pulmonary fluids

    Authors:
    Dobrowolska Katarzyna, Jabłczyńska Katarzyna, Kondej Dorota, Sosnowski Tomasz R.
    Academic press:
    Physicochem. Probl. Min. Process. (year: 2018, volume: 54, pages: 151-162), Publisher: Politechnika Wrocławska
    Status:
    Published
    DOI:
    10.5277/ppmp1837 – link to the publication

  5. Powder particles and technologies for medicine delivery to the respiratory system: challenges and opportunities

    Authors:
    Sosnowski Tomasz R.
    Academic press:
    KONA Powder and Particle Journal (year: 2018, volume: 35, pages: 122-138), Publisher: Hosokawa Powder Technology Foundation
    Status:
    Published
    DOI:
    10.14356/kona.2018020 – link to the publication

  6. New experimental model of pulmonary surfactant for biophysical studies

    Authors:
    Sosnowski Tomasz R., Kubski Paweł, Wojciechowski Kamil
    Academic press:
    Colloids Surfaces A: Physiochem. Eng. Aspects (year: 2017, volume: 519, pages: 27-33), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfa.2016.06.044 – link to the publication

  7. Bronchial mucus as a complex fluid: molecular interactions and influence of nanostructured particles on rheological and transport properties

    Authors:
    Odziomek Marcin, Kalinowska Martyna, Płuzińska Aleksandra, Rożeń Antoni, Sosnowski Tomasz R.
    Academic press:
    Chem. Proc. Eng. (year: 2017, volume: 38, pages: 217-229), Publisher: de Gruyter
    Status:
    Published
    DOI:
    10.1515/cpe-2017-0017 – link to the publication

  8. Surface tension reduction in air/liquid systems containing nonionic surfactant – comparison of mass transfer limited models

    Authors:
    Kramek-Romanowska K., Sosnowski T.R.
    Academic press:
    Inżynieria i Aparatura Chemiczna (year: 2017, volume: 56(3), pages: 78-79), Publisher: Zarząd Główny SIMP
    Status:
    Published
    DOI:
    link to the publication

  9. Predicted deposition of e-cigarette aerosol in the human lungs

    Authors:
    Sosnowski Tomasz R., Kramek-Romanowska Katarzyna
    Academic press:
    J. Aerosol Med. Pulm. Drug Del. (year: 2016, volume: 29(3), pages: 299-309), Publisher: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/jamp.2015.1268 – link to the publication

  10. Badania właściwości reologicznych sztucznego śluzu oskrzelowego i ich wpływu na transport masy w układzie oddechowym

    Authors:
    Dobrowolska Katarzyna, Szamer Katarzyna, Sosnowski Tomasz R.
    Academic press:
    Inżynieria i Aparatura Chemiczna (year: 2018, volume: 57(3), pages: 55-56), Publisher: Zarząd Główny SIMP
    Status:
    Published
    DOI:
    link to the publication

  11. Effect of clay nanoparticles on model lung surfactant: a potential marker of hazard from nanoaerosol inhalation

    Authors:
    Kondej Dorota, Sosnowski Tomasz R.
    Academic press:
    Env. Sci. Pollut. Res. (year: 2016, volume: 23, pages: 4660-4669), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s11356-015-5610-4 – link to the publication

  12. Predicted lung deposition of electronic cigarette aerosols (abstract)

    Authors:
    Sosnowski Tomasz R.
    Academic press:
    J. Aerosol Med. Pulm. Drug Del. (year: 2015, volume: 28(3), pages: A28-A29), Publisher: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/jamp.2015.ab01.abstracts – link to the publication

  13. Production of respirable nanostructured powder particles (abstract)

    Authors:
    Jabłczyńska Katarzyna, Sosnowski Tomasz R.
    Academic press:
    J. Aerosol Med. Pulm. Drug Del. (year: 2015, volume: 28(3), pages: A20), Publisher: Mary Ann Liebert, Inc.
    Status:
    Published
    DOI:
    10.1089/jamp.2015.ab01.abstracts – link to the publication

  14. Selected engineering and physicochemical aspects of systemic drug delivery by inhalation

    Authors:
    Sosnowski Tomasz R.
    Academic press:
    Curr. Pharm. Des. (year: 2016, volume: 22(17), pages: 2453 – 2462), Publisher: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1381612822666160128145644 – link to the publication

  15. Interactions of carbon nanotubes and carbon nanohorns with a model membrane layer and lung surfactant in vitro

    Authors:
    Kondej Dorota, Sosnowski Tomasz R.
    Academic press:
    Journal of Nanomaterials (year: 2019, volume: 2019, pages: Article ID 9457683), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/9457683 – link to the publication

  16. Mikrotensjometryczna analiza zmian aktywności powierzchniowej surfaktantu niejonowego w obecności nanostrukturalnych cząstek mineralnych

    Authors:
    Lenard Martyna, Sosnowski Tomasz R.
    Academic press:
    Inżynieria i Aparatura Chemiczna (year: 2015, volume: 54(6), pages: 334-335), Publisher: Zarząd Główny SIMP
    Status:
    Published
    DOI:
    link to the publication

  17. Badanie wpływu nanomateriałów węglowych na surfaktant płucny metodą pulsującej kropli

    Authors:
    Dymowski Konrad, Mazurkiewicz-Pawlicka Marta, Sosnowski Tomasz R.
    Academic press:
    Inżynieria i Aparatura Chemiczna (year: 2017, volume: 56(3), pages: 68-69), Publisher: Zarząd Główny SIMP
    Status:
    Published
    DOI:
    link to the publication

  18. Inactivation of pulmonary surfactant by nanoparticles - in vitro studies by DSA method (abstract)

    Authors:
    Sosnowski Tomasz R., Dymowski Konrad, Mazurkiewicz-Pawlicka Marta
    Academic press:
    J. Aerosol Med. Pulm. Drug Deliv. (year: 2017, volume: 30(3), pages: A34), Publisher: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/jamp.2017.ab01.abstracts – link to the publication

Articles in post-conference publications (18)

  1. Adsorption dynamics of model pulmonary surfactants at the air/water interface: a comparison of existing mathematical models

    Authors:
    Kramek-Romanowska Katarzyna, Sosnowski Tomasz R.
    Conference:
    XXII Ogólnopolska Konferencja Inżynierii Chemicznej i Procesowej (year: 2016, pages: 605-610), Publisher: Exall
    Date:
    conference 5-9.09.2016
    Status:
    Published

  2. Effect of diesel-emitted nanostructured particles on the apparent surface rheology of model lung surfactant

    Authors:
    Sosnowski Tomasz R., Penconek Agata, Jabłczyńska Katarzyna
    Conference:
    5th Int. Acad. Conference Chemistry & Chemical Technology 2016 (within 6th Int. Youth Science Forum Litteris et Artibus) (year: 2016, pages: 446-448), Publisher: Lviv Polytechnic Publishing House
    Date:
    conference 24-26.11.2016
    Status:
    Published

  3. Influence of nanostructured particles on the mass transfer rate in bronchial mucus

    Authors:
    Odziomek Marcin, Sosnowski Tomasz R.
    Conference:
    10th World Congress of Chemical Engineering (year: 2017, pages: 1259), Publisher: EFCE
    Date:
    conference 1-5.10.2017
    Status:
    Published

  4. Surface tension of oscillating gas/liquid interface - biophysical modeling of lung surfactant (LS) dynamics

    Authors:
    Sosnowski Tomasz R.
    Conference:
    International Scientific Conference Chemical Technology and Engineering (year: 2017, pages: 236-237), Publisher: Lviv Polytechnic
    Date:
    conference 26-30.06.2017
    Status:
    Published

  5. Emulsions as precursors for structurized inhalable microparticles

    Authors:
    Jabłczyńska Katarzyna, Górska Katarzyna, Sosnowski Tomasz R.
    Conference:
    XI Konferencja Przepływów Wielofazowych, Gdańsk (year: 2015, pages: 20-21), Publisher: Politechnika Gdańska
    Date:
    conference 7-9.10.2015
    Status:
    Published

  6. Physicochemical sensing of possible health effects from inhalation of nanostructured diesel particles

    Authors:
    Sosnowski Tomasz R.
    Conference:
    10th World Congress of Chemical Engineering (year: 2017, pages: 1266), Publisher: EFCE
    Date:
    conference 1-5.10.2017
    Status:
    Published

  7. Physicochemical assessment of the impact of nanoparticles on the pulmonary surfactant using an oscillation drop method

    Authors:
    Sosnowski Tomasz R., Jabłczyńska Katarzyna, Dobrowolska Katarzyna
    Conference:
    Respiratory Drug Delivery 2018, Tucson, USA (year: 2018, pages: 681-684), Publisher: VCU
    Date:
    conference 22-26.04.2018
    Status:
    Published

  8. Dynamic interfacial characteristics of the lung surfactant contaminated by nanostructured particles

    Authors:
    Sosnowski Tomasz R.
    Conference:
    157th Seminar of International Centre of Biocybernetics Polish Academy of Sciences Nanoparticles and Nanotechnology for Biomedical Engineering and Medicine (year: 2017, pages: 28-31), Publisher: IBIB PAN
    Date:
    conference 15-17.10.2017
    Status:
    Published

  9. Rheological analysis of air-liquid interface for the quantitative assessment of lung surfactant dynamics

    Authors:
    Dobrowolska Katarzyna, Jabłczyńska Katarzyna, Sosnowski Tomasz R.
    Conference:
    23rd Polish Conference of Chemical and Process Engineering (year: 2019, pages: 25), Publisher: Faculty of Chemical and Process Engineering, Warsaw University of Technology
    Date:
    conference 2-5.06.2019
    Status:
    Published

  10. Dynamic surface activity of the pulmonary surfactant (PS) - graphene oxide (GO) system

    Authors:
    Sosnowski Tomasz R., Mazurkiewicz- Pawlicka Marta, Małolepszy Artur, Stobiński Leszek
    Conference:
    Smart and Green Interfaces 2016 (year: 2016, pages: 132), Publisher: Aristiotle University of Thessaloniki
    Date:
    conference 4-6.05.2016
    Status:
    Published

  11. Potential toxic effects of selected nanoparticles on pulmonary surfactant system

    Authors:
    Kramek-Romanowska Katarzyna, Sosnowski Tomasz R.
    Conference:
    6th European Young Engineers Conference (year: 2017, pages: 279), Publisher: Warsaw University of Technology
    Date:
    conference 24-26.04.2017
    Status:
    Published

  12. Particle displacement on DPPC monolayer at air-water interface

    Authors:
    Sosnowski Tomasz R.
    Conference:
    Dotchi Exerova Symposium Smart and Green Interfaces: Fundamentals and Diagnostics (year: 2015, pages: 108), Publisher: Bulgarian Acedemy of Sciences
    Date:
    conference 29-31.10.2015
    Status:
    Published

  13. Mikrotensjometryczna analiza zmian aktywności powierzchniowej surfaktantu niejonowego w obecności nanostrukturalnych cząstek mineralnych

    Authors:
    Lenard Martyna, Sosnowski Tomasz R.
    Conference:
    XI Konferencja Przepływów Wielofazowych, Gdańsk (year: 2015, pages: 26), Publisher: Politechnika Gdańska
    Date:
    conference 7-9.10.2015
    Status:
    Published

  14. Wpływ składników śluzu oskrzelowego na jego właściwości reologiczne oraz transportowe

    Authors:
    Odziomek Marcin, Kalinowska Martyna, Sosnowski Tomasz R.
    Conference:
    XXII Ogólnopolska Konferencja Inżynierii Chemicznej i Procesowej (year: 2016, pages: 1044-1050), Publisher: Exall
    Date:
    conference 5-9.09.2016
    Status:
    Published

  15. Electronic cigarette as a source of aerosols inhaled by users and by-standers

    Authors:
    Sosnowski Tomasz R.
    Conference:
    XXII Ogólnopolska Konferencja Inżynierii Chemicznej i Procesowej (year: 2016, pages: 1266-1269), Publisher: Exall
    Date:
    conference 5-9.09.2016
    Status:
    Published

  16. Towards basic knowledge on interactions between inhaled nano-structured particles and lung surface: a physicochemical approach

    Authors:
    Sosnowski Tomasz R.
    Conference:
    International Conference Advances in pneumology (year: 2016, pages: bd), Publisher: Biophilia
    Date:
    conference 7-8.10.2016
    Status:
    Published
    DOI:
    link to the publication

  17. New engineering strategies for improvement of drug delivery by aersosol inhalation

    Authors:
    Sosnowski Tomasz R.
    Conference:
    Smart and Green Interfaces 2016 (year: 2016, pages: 39), Publisher: Aristotle University of Thessaloniki
    Date:
    conference 4-6.05.2016
    Status:
    Published

  18. Electronic cigarette: a suboptimal inhalation device

    Authors:
    Sosnowski Tomasz R.
    Conference:
    International Conference Advances in pneumology (year: 2016, pages: bd), Publisher: Biophilia
    Date:
    conference 7-8.10.2016
    Status:
    Published
    DOI:
    link to the publication

Book publications / chapters in book publications (1)

  1. Chemical engineering in biomedical problems – selected applications

    Authors:
    Moskal Arkadiusz, Sosnowski Tomasz R.
    Book:
    Practical Aspects of Chemical Engineering (year: 2018, volume: 1, pages: 307-318), Publisher: Springer Int. Publ. AG
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski