Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of abnormalities of fatty acids profile in chronic kidney disease

2013/11/B/NZ5/00118

Keywords:

lipids fatty acids chronic kidney disease gas chromatography-mass spectrometry dislipidaemia cardiovascular diseases

Descriptors:

  • ST4_6: Instrumental methods in chemistry
  • NZ4_11: Metabolism
  • NZ5_1: Etiology of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Gdański Uniwersytet Medyczny, Wydział Lekarski

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Michał Chmielewski 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 1 134 618 PLN

Project start date (Y-m-d): 2014-08-07

Project end date (Y-m-d): 2018-01-06

Project duration:: 41 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Chromatograf gazowy sprzężony ze spektrometrem mas (GC-MS) (310 000 PLN)
  2. Wytrząsarka vortex.
  3. wytrząsarka laboratoryjna.
  4. Myjnia ultradźwiękowa.
  5. Suszarka laboratoryjna.
  6. Termostat dwublokowy.
  7. Urządzenie wielofunkcyjne (drukarka, kopiarka, skaner).
  8. Komputer.
  9. Wirówka laboratoryjna analogiczna kątowa (1 800 PLN)
  10. Aparatura do Western blotting (22 000 PLN)
  11. Waga precyzyjna z mieszadłem.
  12. Wyparka obrotowa R-215/V (23 520 PLN)

Information in the final report

  • Publication in academic press/journals (10)
  1. Cyclopropaneoctanoic Acid 2-Hexyl upregulates the expression of genes responsible for lipid synthesis and release in human hepatic HepG2 cells
    Authors:
    Czumaj A, Mika A, Chmielewski M, Sledzinski T
    Academic press:
    Lipids (rok: 2018, tom: 53(3), strony: 345-351), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1002/lipd.12034 - link to the publication
  2. Disorders of Serum Polyunsaturated Fatty Acids in Renal Transplant Patients
    Authors:
    Sikorska-Wisniewska M, Mika A, Sledzinski T, Czaplinska M, Malgorzewicz S, Debska-Slizien A, Chmielewski M.
    Academic press:
    Transplant Proc (rok: 2020, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.transproceed.2020.01.106 - link to the publication
  3. Contribution of increased expression of stearoyl-CoA desaturase-1 in adipose tissue to serum content of monounsaturated fatty acids in patients with chronic kidney disease
    Authors:
    Chmielewski M, Korczyńska J, Śledziński M, Czaplińska M, Dębska-Ślizień A, Mika A
    Academic press:
    Pol Arch Intern Med (rok: 2019, tom: 129(9), strony: 641-644), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.14871 - link to the publication
  4. Potential contribution of monounsaturated fatty acids to cardiovascular risk during the progress of chronic kidney disease
    Authors:
    Mika A, Sikorska-Wiśniewska M, Stepnowski P, Malgorzewicz S, Sledzinski T, Chmielewski M
    Academic press:
    Pol Arch Intern Med (rok: 2018, tom: 128(12), strony: 755-763), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.4376 - link to the publication
  5. Application of nuclear magnetic resonance spectroscopy for the detection of metabolic disorders in patients with moderate kidney insufficiency.
    Authors:
    Mika A, Wojtowicz W, Ząbek A, Młynarz P, Chmielewski M, Sledzinski T, Stepnowski P
    Academic press:
    J Pharm Biomed Anal (rok: 2018, tom: 149, strony: 45299), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.037 - link to the publication
  6. Disorders of serum omega-3 fatty acid composition in dialysis patients, and their associations with fat mass
    Authors:
    Sikorska-Wisniewska M, Mika A, Sledzinski T, Malgorzewicz S, Stepnowski P, Rutkowski B, Chmielewski M
    Academic press:
    Renal Failure (rok: 2017, tom: 1,62569444444444, strony: 406-412), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/0886022X.2017.1295870 - link to the publication
  7. Suitability of selected chromatographic columns for analysis of fatty acids in dialyzed patients
    Authors:
    Pazda M, Stepnowski P, Sledzinski T, Chmielewski M, Mika A
    Academic press:
    Biomedical Chromatography (rok: 2017, tom: 31(11), strony: e4006), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/bmc.4006 - link to the publication
  8. Increased Expression of the Leptin Gene in Adipose Tissue of Patients with Chronic Kidney Disease-The Possible Role of an Abnormal Serum Fatty Acid Profile
    Authors:
    Korczyńska J, Czumaj A, Chmielewski M, Śledziński M, Mika A, Śledziński T.
    Academic press:
    Metabolites (rok: 2020, tom: 10(3), strony: 98), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/metabo10030098 - link to the publication
  9. Increased serum level of cyclopropaneoctanoic acid 2-hexyl in patients with hypertriglyceridemia-related disorders
    Authors:
    Mika A, Stepnowski P, Chmielewski M, Malgorzewicz S, Kaska L, Proczko M, Ratnicki-Sklucki K, Sledzinski M, Sledzinski T
    Academic press:
    Lipids (rok: 2016, tom: 51(7), strony: 867-873), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11745-016-4141-1 - link to the publication
  10. Alterations of Fatty Acid Profile May Contribute to Dyslipidemia in Chronic Kidney Disease by Influencing Hepatocyte Metabolism
    Authors:
    Czumaj A, Śledziński T, Carrero JJ, Stepnowski P, Sikorska-Wisniewska M, Chmielewski M, Mika A.
    Academic press:
    Int J Mol Sci (rok: 2019, tom: 20(10), strony: 2470), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20102470 - link to the publication

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