Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Oral endoglin based-DNA vaccine combined with gene encoding IL-12 can polarize tumor microenvironment from proangiogenic and immunosuppressive phenotype to antiangiogenic and immunostimulatory

2013/11/B/NZ4/04468

Keywords:

Antiangiogenic vaccine IL-12 tumor associated macrophages (TAM) normalization of tumor vasculature vessel perfusion macrophage phenotype polarization

Descriptors:

  • NZ4_12: Other related subjects
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Centrum Onkologii - Instytut im. Marii Skłodowskiej-Curie, Oddział w Gliwicach

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Jarosz-Biej 

Number of co-investigators in the project: 9

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 599 410 PLN

Project start date (Y-m-d): 2014-07-11

Project end date (Y-m-d): 2017-07-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka z chłodzeniem (20 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (2)
  1. Combined Tumor Cell-Based Vaccination and Interleukin-12 Gene Therapy Polarizes the Tumor Microenvironment in Mice
    Authors:
    Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Cichoń, Natalia Kułach, Justyna Czapla, Sybilla Matuszczak, Stanisław Szala
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2015, tom: 63, strony: 451–464), Wydawca: Springer Basel
    Status:
    Published
    DOI:
    10.1007/s00005-015-0337-y - link to the publication
  2. M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma
    Authors:
    Magdalena Jarosz-Biej, Natalia Kamińska, Sybilla Matuszczak, Tomasz Cichoń, Jolanta Pamuła-Piłat, Justyna Czapla, Ryszard Smolarczyk, Daria Skwarzyńska, Klaudia Kulik, Stanisław Szala
    Academic press:
    PLOS ONE (rok: 2018, tom: 13, strony: e0191012), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0191012 - link to the publication
  1. Effect of tumor cell-based vaccine and IL-12 gene therapy on the tumor microenvironment in mice
    Authors:
    Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Cichoń, Natalia Kułach, Justyna Czapla, Sybilla Matuszczak, Stanisław Szala
    Conference:
    7th International Conference of Contemporary Oncology "Personalized Cancer Medicine and Big Data Analysis" (rok: 2015, ), Wydawca: Contemporary Oncology, Termedia Publishing House
    Data:
    konferencja 25.-27.03.2015
    Status:
    Published
  2. The effect of combination therapy (endoglin-based DNA vaccine with interleukin-12) on tumor blood vessels
    Authors:
    Magdalena Jarosz-Biej, Natalia Kamińska, Tomasz Cichoń, Sybilla Matuszczak, Ryszard Smolarczyk, Klaudia Kulik, Stanisław Szala
    Conference:
    8th International Conference of Contemporary Oncology "Integrated Oncology: Genomics, Immunotherapies, and Molecular Targets" (rok: 2016, ), Wydawca: Contemporary Oncology, Termedia Publishing House
    Data:
    konferencja 16-18.03.2016
    Status:
    Published
    DOI:
    link to the publication
  3. The endoglin-based DNA vaccine with IL-12 polarizes tumor-associated macrophages phenotype from M2 (tumor growth-promoting) into M1 (tumor growth-inhibiting)
    Authors:
    Magdalena Jarosz-Biej, Sybilla Matuszczak, Natalia Kamińska, Tomasz Cichoń, Klaudia Kulik, Ryszard Smolarczyk, Justyna Czapla, Stanisław Szala
    Conference:
    Congress BIO 2016 Expanding beyond the limits" (rok: 2016, ), Wydawca: Acta Biochimica Polonica; Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Data:
    konferencja 13-16.09.2016
    Status:
    Published
    DOI:
    link to the publication
  1. Polarization of tumor milieu: therapeutic implications
    Authors:
    Stanisław Szala, Magdalena Jarosz-Biej, Tomasz Cichoń, Ryszard Smolarczyk, Aleksander Sochanik
    Book:
    Cancer Immunology: Translational Medicine from Bench to Bedside (rok: 2015, tom: nie dotyczy, strony: 401-408), Wydawca: Springer Berlin Heidelberg
    Status:
    Published
  2. Reprogramming of tumor microenvironment in therapy
    Authors:
    Magdalena Jarosz-Biej, Ryszard Smolarczyk, Tomasz Cichoń, Stanisław Szala
    Book:
    Cancer Immunology, 2nd ed (rok: 2019, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Springer-Verlag Berlin Heidelberg
    Status:
    Accepted for publication

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