Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Photo-induced oxidizing reactions of peptides and proteins containing the thioether group. Mechanisms of reactions - formation of intramolecular two-centered three-electron (S:.O), (S:.N) and (S:.S) bond species.

2013/11/B/ST4/00811

Keywords:

photochemistry pulse radiolysis thioether group peptides proteins three-electron-bonds oxidation methionine residue,

Descriptors:

  • ST4_17: Chemical reactions: mechanisms, thermodynamics, kinetics
  • ST4_16: Ionic liquids
  • ST4_14: Catalysis

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Chemii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Filipiak 

Number of co-investigators in the project: 8

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 641 280 PLN

Project start date (Y-m-d): 2014-07-22

Project end date (Y-m-d): 2018-01-21

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer przenośny osobisty (5 000 PLN)
  2. Wysokociśnieniowy Chromatograf Cieczowy (HPLC) z detektorem absorpcyjnym (DAD) (265 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (2)
  1. Formation of Three-Electron Sulfur-Sulfur Bond as a Probe for Interaction between Side Chains of Methionine Residues.
    Authors:
    Piotr Filipiak, Krzysztof Bobrowski, Gordon L. Hug, Dariusz Pogocki, Christian Schöneich, Bronislaw Marciniak
    Academic press:
    The Journal of Physical Chemistry: B (rok: 2016, tom: 120, strony: 9732-9744), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.6b06494 - link to the publication
  2. New Insights into the Reaction Paths of 4-Carboxybenzophenone Triplet with Oligopeptides containing N- and C-terminal Methionine Residues.
    Authors:
    Piotr Filipiak, Krzysztof Bobrowski, Gordon L. Hug, Dariusz Pogocki, Christian Schöneich, Bronislaw Marciniak
    Academic press:
    The Journal of Physical Chemistry: B (rok: 2017, tom: 121, strony: 5247-5258), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.7b01119 - link to the publication
  3. Oxidation studies of a novel peptide model N-acetyl-3-(methylthio)propylamine
    Authors:
    Tomasz Pędziński, Franciszek Kaźmierczak, Piotr Filipiak, Bronislaw Marciniak
    Academic press:
    Journal of Photochemistry and Photobiology A: Chemistry (rok: 2017, tom: 336, strony: 98-104), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jphotochem.2016.12.032 - link to the publication
  4. Unexpected reaction pathway of the alpha-aminoalkyl radical derived from one-electron oxidation of S-alkylglutathiones
    Authors:
    Tomasz Pędziński, Krzysztof Bobrowski, Bronislaw Marciniak, Piotr Filipiak
    Academic press:
    Molecules (ISSN 1420-3049; CODEN: MOLEFW) (rok: 2020, tom: 25, strony: 877), Wydawca: MDPI AG - Open Access Journal
    Status:
    Published
    DOI:
    10.3390/molecules25040877 - link to the publication
  5. N-terminal Decarboxylation as a Probe for Intramolecular Contact Formation in γ-Glu-(Pro)n-Met Peptides
    Authors:
    Piotr Filipiak, Krzysztof Bobrowski, Gordon L. Hug, Christian Schoneich, Bronisław Marciniak
    Academic press:
    The Journal of Physical Chemistry: B (rok: 2020, ), Wydawca: ACS Publications
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Formation of Three-Electron Sulfur-Sulfur Bond as a Probe for Interaction between Side Chains of Methionine Residues
    Authors:
    P. Filipiak, K. Bobrowski, G. L. Hug, D. Pogocki, Ch. Schöneich, B. Marciniak
    Conference:
    59 Zjazd Naukowy Polskiego Towarzystwa Chemicznego, (rok: 2016, ), Wydawca: Polskie Towarzystwo Chemiczne, ul. Freta 16, 00-227 Warszawa
    Data:
    konferencja 19-23 września
    Status:
    Published
  2. Unexpected reaction pathway of the alpha-aminoalkyl radical derived from one-electron oxidation of S-alkyl-glutathiones
    Authors:
    Tomasz Pedzinski, Piotr Filipiak, Gordon L. Hug, Krzysztof Bobrowski, Bronislaw Marciniak
    Conference:
    The 19th biennial meeting for the Society for Free Radical Research International (SFRRI) (rok: 2018, ), Wydawca: SFRRI
    Data:
    konferencja 4-7 czerwca
    Status:
    Published
    DOI:
    link to the publication

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