Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Analysis of changes in gene expression and regulatory mechanisms in the tissue of neuropathic ulcers in patients with type 2 diabetes mellitus treated with negative pressure wound therapy (NPWT).

2013/11/B/NZ5/03298

Keywords:

DM2 miRNA neuropathic ulcer NPWT

Descriptors:

  • NZ4_11: Metabolism
  • NZ4_6: Endocrinology
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Jagielloński – Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maciej Małecki 

Number of co-investigators in the project: 3

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 694 340 PLN

Project start date (Y-m-d): 2014-08-04

Project end date (Y-m-d): 2018-08-03

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. RENASYS EZ - urządzenie do podcisnieniowego leczenia ran. (16 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  1. Effects of Negative Pressure Wound Therapy on Levels of Angiopoetin-2 and Other Selected Circulating Signaling Molecules in Patients with Diabetic Foot Ulcer.
    Authors:
    Hohendorff J, Drozdz A, Borys S, Ludwig-Slomczynska AH, Kiec-Wilk B, Stepien EL, Malecki MT
    Academic press:
    Journal of Diabetes Research (rok: 2019, tom: 2019:1756798, strony: 2019:1756798), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2019/1756798. - link to the publication
  2. NPWT in diabetic foot wounds—a systematic review and meta- analysis of observational studies.
    Authors:
    Rys P, Borys S, Hohendorff J, Zapala A, Witek P, Monica M, Frankfurter C, Ludwig-Slomczynska A, Kiec-Wilk B, Malecki MT
    Academic press:
    Endocrine (rok: 2020, tom: N/A, strony: N/A), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12020-019-02164-9. - link to the publication
  3. Negative pressure wound therapy use in diabetic foot syndrome—from mechanisms of action to clinical practice
    Authors:
    Borys S, Frankfurter C, Kiec-Wilk B, Malecki MT
    Academic press:
    European Journal of Clinical Investigation (rok: 2019, tom: 49, strony: e13067), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/eci.13067. - link to the publication
  4. Negative pressure wound therapy may affect circulating plasma microRNAs in patients with diabetic foot ulceration.
    Authors:
    Kapusta P, Konieczny PS, Hohendorff J, Borys S, Totoń-Żurańska J, Kieć-Wilk BM, Wołkow PP, Malecki MT
    Academic press:
    Diabetes Research and Clinical Practice (rok: 2020, tom: n/a, strony: n/a), Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. DNA methylation analysis of negative pressure therapy effect in diabetic foot ulcers.
    Authors:
    Ludwig-Slomczynska A, Borys S, Seweryn M, Hohendorff J, Kapusta P, Kiec-Wilk B, Pitera E, Wolkow P, Malecki MT
    Academic press:
    Endocrine Connections (rok: 2019, tom: 8, strony: 1474-1482), Wydawca: Bioscientifica
    Status:
    Published
    DOI:
    10.1530/EC-19-0373. - link to the publication
  6. Negative Pressure Wound Therapy In The Treatment of Diabetic Foot Ulcers May Be Mediated Through Differential Gene Expression
    Authors:
    S. Borys, A.H. Ludwig-Slomczynska, Michal Seweryn, Jerzy Hohendorffa, Teresa Koblik, Julita Machlowska, Beata Kiec-Wilk, Pawel Wolkow, Maciej T. Malecki
    Academic press:
    Acta Diabetologica (rok: 2019, tom: 56, strony: 115–120), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00592-018-1223-y - link to the publication
  7. Negative-pressure wound therapy for management of chronic neuropathic noninfected diabetic foot ulcerations - short-term efficacy and long-term outcomes.
    Authors:
    Borys S, Hohendorff J, Koblik T, Witek P, Ludwig-Slomczynska AH, Frankfurter C, Kiec-Wilk B, Malecki MT
    Academic press:
    Endocrine (rok: 2018, tom: 62, strony: 611-616), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12020-018-1707-0 - link to the publication

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