Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Pharmacokinetic and pharmacodynamic interactions of the ECG modifying drugs - key covariates analysis.

2013/11/D/NZ7/01583

Keywords:

drug interactions polypharmacy ECG QTc mathematical modelling

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Barbara Wiśniowska 

Number of co-investigators in the project: 3

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 95 540 PLN

Project start date (Y-m-d): 2014-07-28

Project end date (Y-m-d): 2017-01-27

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Serwer obliczeniowy (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. How in vitro influences in silico utilized for the prediction of in vivo — pilot study of the drug-induced pro-arrhythmic potency prediction.
    Authors:
    Bogna Badyra, Bartosz Lisowski, Sebastian Polak, John Kudolo, Barbara Wiśniowska
    Academic press:
    Folia Medica Cracoviensia (rok: 2015, tom: 4, strony: 0), Wydawca: Komisja Nauk Medycznych - Oddział PAN w Krakowie
    Status:
    Published
    DOI:
    brak - link to the publication
  2. The role of interaction model in simulation of drug interactions and QT prolongation.
    Authors:
    Barbara Wiśniowska, Sebastian Polak
    Academic press:
    Current Pharmacology Reports (rok: 2016, tom: 2, strony: 339), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s40495-016-0075-9 - link to the publication
  3. Drug-drug interactions and QT prolongation as a commonly assessed cardiac effect - comprehensive overview of clinical trials.
    Authors:
    Barbara Wiśniowska, Zofia Tylutki, Gabriela Wyszogrodzka, Sebastian Polak.
    Academic press:
    BMC Pharmacology and Toxicology (rok: 2016, tom: 0,716666666666667, strony: 0), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s40360-016-0053-1 - link to the publication
  4. Virtual Clinical Trial Toward Polytherapy Safety Assessment: Combination of Physiologically Based Pharmacokinetic/Pharmacodynamic-Based Modeling and Simulation Approach With Drug-Drug Interactions Involving Terfenadine as an Example.
    Authors:
    Barbara Wiśniowska, Sebastian Polak
    Academic press:
    Journal of Pharmaceutical Sciences (rok: 2016, tom: 105(11), strony: 3415-3424), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.xphs.2016.08.002 - link to the publication

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