Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Expression of coagulation proteins as factor causes enhanced local inflammation, apoptosis disorders and calcification in human stenotic aortic valves: the impact of modifying factors on the clotting activity.

2013/11/B/NZ5/00157

Keywords:

aortic stenosis coagulation cascade apoptosis inflammation myofibroblasts

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Krakowski Szpital Specjalistyczny im. Jana Pawła II

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Ewa Wypasek 

Number of co-investigators in the project: 3

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 411 632 PLN

Project start date (Y-m-d): 2014-12-05

Project end date (Y-m-d): 2019-06-04

Project duration:: 54 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Adaptery HERMLE do wirówki / 7x15 ml-2 szt., 7x5-7 ml-2szt./.
  2. Lodówka laboratoryjna LIEBHERR K 4270 Premium.
  3. Mini&MidiMACS - aparat do magnetycznego sortowania komórek (14 000 PLN)
  4. Zamrażarka laboratoryjna LIEBHERR GN 3023 Comfort.

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Interaction between functional polymorphisms in FCER1A and TLR2 and the severity of atopic dermatitis
    Authors:
    Daniel P. Potaczek, Aleksandra Przytulska-Szczerbik, Stanisława Bazan-Socha, Magdalena Nastałek, Anna Wojas-Pelc, Ko Okumura, Chiharu Nishiyama, Artur Jurczyszyn, Anetta Undas, Ewa Wypasek
    Academic press:
    Human Immunology (rok: 2020, tom: 81, strony: 709-713), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.humimm.2020.08.002 - link to the publication
  2. Association of the C-Reactive Protein Gene (CRP) rs1205 C>T Polymorphism with Aortic Valve Calcification in Patients with Aortic Stenosis
    Authors:
    Wypasek E, Potaczek DP, Undas A.
    Academic press:
    Int J mol Sci (rok: 2015, tom: 16(10), strony: 23745-59.), Wydawca: International Journal of Molecular Sciences
    Status:
    Published
    DOI:
    10.3390/ijms161023745 - link to the publication
  3. Effects of rivaroxaban and dabigatran on local expression of coagulation and inflammatory factors within human aortic stenotic valves
    Authors:
    Ewa Wypasek, Joanna Natorska, Piotr Mazur, Magdalena Kopytek, Bogusław Gawęda, Przemysław Kapusta, Jacek Madeja, Teresa Iwaniec, Bogusław Kapelak, Anetta Undas
    Academic press:
    Vascular Pharmacology (rok: 2020, tom: 130, strony: 106679), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vph.2020.106679 - link to the publication
  4. Elements of Immunoglobulin E Network Associate with Aortic Valve Area in Patients with Acquired Aortic Stenosis
    Authors:
    Daniel P. Potaczek, Aleksandra Przytulska-Szczerbik, Stanisława Bazan-Socha, Artur Jurczyszyn, Ko Okumura, Chiharu Nishiyama, Anetta Undas, Ewa Wypasek
    Academic press:
    Biomedicines (rok: 2020, tom: 9, strony: 23), Wydawca: MDPI9
    Status:
    Published
    DOI:
    10.3390/biomedicines9010023 - link to the publication
  1. Human aortic valve interstitial cells express coagulation factors: the impact of inflammatory stimulation
    Authors:
    Wypasek E, Natorska J, Mazur P, Kapusta P, Undas A.
    Conference:
    ESC Congress, Italy, Rome (rok: 2016, ), Wydawca: ESC
    Data:
    konferencja 27-31.08.
    Status:
    Published
    DOI:
    link to the publication
  2. Effects of dabigatran on prothrombin, factor VII and tissue factor expression in human aortic valve interstitial cells.
    Authors:
    Wypasek E, Natorska J, Mazur P, Kapusta P, Undas A.
    Conference:
    ESC Congress 2016, Italy, Rome (rok: 2016, ), Wydawca: ESC
    Data:
    konferencja 27-31.08. 2016.
    Status:
    Published

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