Essential features of miRNA precursors required for release of homogenous siRNAs from shRNA-miR vectors.
2013/11/N/NZ1/02429
Keywords
Descriptors
- NZ1_1: Biologia molekularna
- NZ1_4: Biologia strukturalna
- NZ1_2: Biochemia
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Instytut Chemii Bioorganicznej PAN
Voivodeship: wielkopolskie
Principal investigator (from the host institution)
dr Paulina Małgorzata Gałka-Marciniak
Number of co-investigators in the project: 2
Call
PRELUDIUM 6 – announced on 2013-09-16
- Amount awarded
- 98 800 PLN
- Project start date
- 2014-07-04
- Project end date
- 2016-07-03
- Project duration
- 24 months (the same as in the proposal)
- Project status
- Project settled
Information in the final report
Publication in academic press/journals (3)
-
Nucleotide sequence of miRNA precursor contributes to cleavage site selection by Dicer
- Authors:
- Starega-Roslan J, Galka-Marciniak P, Krzyzosiak WJ
- Academic press:
- Nucleic Acids Research (year: 2015, volume: 43(22), pages: 10939-10951), Publisher: OXFORD UNIV PRESS
- Status:
- Published
- DOI:
- 10.1093/nar/gkv968 – link to the publication
-
siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA.
- Authors:
- Galka-Marciniak P, Olejniczak M, Starega-Roslan J, Szczesniak MW, Makalowska I, Krzyzosiak WJ.
- Academic press:
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (year: 2016, volume: 1859(4), pages: 639-649), Publisher: ELSEVIER
- Status:
- Published
- DOI:
- 10.1016/j.bbagrm.2016.02.014 – link to the publication
-
Sequence features of Drosha and Dicer cleavage sites affect the complexity of isomiRs.
- Authors:
- Starega-Roslan J, Witkos TM, Galka-Marciniak P, Krzyzosiak WJ
- Academic press:
- International Journal of Molecular Sciences (year: 2015, volume: 16(4), pages: 8110-27), Publisher: MDPI AG
- Status:
- Published
- DOI:
- 10.3390/ijms16048110 – link to the publication