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Transcriptional-epigenetic role of poly(ADP-ribose) polymerase-1 in expression of pro-inflammatory mediators controlled by NF-kappaB axis in myeloid effector cells.

2013/11/D/NZ2/00033

Keywords

Descriptors

  • NZ2_6: Immunogenetyka
  • NZ1_1: Biologia molekularna
  • NZ2_2: Genomika, transkryptomika i epigenomika

Panel

NZ2 – Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Agnieszka Robaszkiewicz

Number of co-investigators in the project: 4

Call

SONATA 6 – announced on 2013-09-16

Amount awarded
499 855 PLN
Project start date
2014-07-22
Project end date
2019-07-21
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Aspirator FTA-1.
  2. Autoklaw.
  3. Dwa zestawy pipet automatycznych.
  4. Fluorymetr Quantus (TM) do pomiaru stężenia DNA, RNA i białka.
  5. Homogenizator ultradźwiękowy.
  6. Inkubator CO2. Cost: 32 500 PLN
  7. Komora laminarna (II klasa bezpieczeństwa). Cost: 25 000 PLN
  8. Mikroskop IB100 z obiektywem PH40x i wsuwką do kontrastu fazowego.
  9. Miniwytrząsarka z ruchem kołyskowym MR-1.
  10. Pipetor.
  11. Rotator Multi RS60.
  12. Rotor do wirówki LMC-3000 na probówki 15 ml.
  13. Termocykler MultiGene.
  14. Urządzenie do documentacji żeli i membran. Cost: 100 000 PLN
  15. Wirówka laboratoryjna LMC-3000.

Information in the final report

Publication in academic press/journals (13)

  1. PARP Traps Rescue the Pro-Inflammatory Response of Human Macrophages in the In Vitro Model of LPS-Induced Tolerance

    Authors:
    Julita Pietrzak, Karolina Gronkowska, Agnieszka Robaszkiewicz
    Academic press:
    Pharmaceuticals (year: 2021, volume: 14, pages: 170), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ph14020170 – link to the publication

  2. Downregulation of PARP1 transcription by promoter-associated E2F4-RBL2- HDAC1-BRM complex contributes to repression of pluripotency stem cell factors in human monocytes

    Authors:
    Ewelina Wiśnik, Tomasz Płoszaj, Agnieszka Robaszkiewicz
    Academic press:
    Scientific Reports (year: 2017, volume: 7, pages: 9483), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-017-10307-z – link to the publication

  3. PARP1 co-regulates EP300-BRG1-dependent transcription of genes involved in breast cancer cell proliferation and DNA repair

    Authors:
    Maciej Sobczak, Andrew Pitt, Corinne M Spickett, Agnieszka Robaszkiewicz
    Academic press:
    Cancers (year: 2019, volume: 11, pages: 1539), Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
    Status:
    Published
    DOI:
    10.3390/cancers11101539 – link to the publication

  4. Poly(ADP-ribose) in the bone: From oxidative stress signal to structural element

    Authors:
    Csaba Hegedűs, Agnieszka Robaszkiewicz, Petra Lakatos, Éva Szabó, László Virág
    Academic press:
    Free Radical Biology and Medicine (year: 2015, volume: 82, pages: 179-186), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2015.01.027 – link to the publication

  5. LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis.

    Authors:
    Regdon Z., Robaszkiewicz A., Kovács K., Rygielska Ż., Hegedűs C., Bodoor K., Szabó É., Virág L.
    Academic press:
    Free Radical Biology and Medicine (year: 2019, volume: 131, pages: 184-196), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2018.11.034 – link to the publication

  6. PARP1-LSD1 functional interplay controls transcription of SOD2 that protects human pro-inflammatory macrophages from death under an oxidative condition.

    Authors:
    Tokarz P., Płoszaj T., Regdon Z., Virág L., Robaszkiewicz A.
    Academic press:
    Free Radical Biology and Medicine (year: 2019, volume: 131, pages: 218-224), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2018.12.004 – link to the publication

  7. BRG1 Activates Proliferation and Transcription of Cell Cycle-Dependent Genes in Breast Cancer Cells

    Authors:
    Maciej Sobczak, Julita Pietrzak, Tomasz Płoszaj, Agnieszka Robaszkiewicz
    Academic press:
    Cancers (year: 2020, volume: 12, pages: 349), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers12020349 – link to the publication

  8. EP300-HDAC1-SWI/SNF functional unit defines transcription of some DNA repair enzymes during differentiation of human macrophages

    Authors:
    Pietrzak J., Płoszaj T., Pułaski Ł., Robaszkiewicz A.
    Academic press:
    BBA - Gene Regulatory Mechanisms (year: 2019, volume: 1862, pages: 198-208), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2018.10.019 – link to the publication

  9. Downregulation of PARP1 transcription by CDK4/6 inhibitors sensitizes human lung cancer cells to anticancer drug-induced death by impairing OGG1-dependent base excision repair

    Authors:
    Tempka Dominika, Tokarz Paulina, Chmielewska Kinga, Kluska Magdalena, Pietrzak Julita, Rygielska Żaneta, Virág Laszlo, Robaszkiewicz Agnieszka
    Academic press:
    Redox Biology (year: 2018, volume: 15, pages: 316-326), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2017.12.017 – link to the publication

  10. PARP1 facilitates EP300 recruitment to the promoters of the subset of RBL2-dependent genes.

    Authors:
    Robaszkiewicz Agnieszka, Wiśnik Ewelina, Regdon Zsolt, Chmielewska Kinga, Virág Laszlo
    Academic press:
    BBA - Gene Regulatory Mechanisms (year: 2018, volume: 1861, pages: 41-53), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2017.12.001 – link to the publication

  11. Redox Profiling Reveals Clear Differences between Molecular Patterns of Wound Fluids from Acute and Chronic Wounds

    Authors:
    Bodnár E., Bakondi E., Kovács K., Hegedűs C., Lakatos P., Robaszkiewicz A., Regdon Z., Virág L., Szabó É.
    Academic press:
    Oxidative Medicine and Cellular Longevity (year: 2018, volume: 2018, pages: Article ID 5286785 (12 stron)), Publisher: Hindawi
    Status:
    Published
    DOI:
    10.1155/2018/5286785 – link to the publication

  12. Redox control of cancer cell destruction

    Authors:
    CsabaHegedűsa, Katalin Kovács, Zsuzsanna Polgára, Zsolt Regdona, Éva Szabó, Agnieszka Robaszkiewicz, Henry Jay Forman, Anna Martner, László Virág
    Academic press:
    Redox Biology (year: 2018, volume: 16, pages: 59-74), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2018.01.015 – link to the publication

  13. ARTD1 regulates osteoclastogenesis and bone homeostasis by dampening NF-κB-dependent transcription of IL-1β

    Authors:
    Agnieszka Robaszkiewicz, Chao Qu, Ewelina Wiśnik, Tomasz Płoszaj, Ali Mirsaidi, Friedrich A. Kunze, Peter J. Richards, Paolo Cinelli, Gabriel Mbalaviele, Michael O. Hottiger
    Academic press:
    Scientific Reports (year: 2016, volume: 6, pages: 21131), Publisher: Nature
    Status:
    Published
    DOI:
    10.1038/srep21131 – link to the publication

Book publications / chapters in book publications (5)

  1. Biochemical and cellular aspects of protein mono- and poly(ADP-ribosyl)ation.

    Authors:
    Agnieszka Robaszkiewicz, Ewelina Wiśnik
    Book:
    Badania i Rozwój Młodych Naukowców w Polsce: Nauki Przyrodnicze (year: 2015, volume: 1, pages: 126-131), Publisher: Młodzi Naukowcy, ISBN: 978-83-942083-1-8
    Status:
    Published

  2. Syntetyczna letalność w komórkach nowotworowych a inhibitory polimeraz poli(ADP-rybozy).

    Authors:
    Ewelina Wiśnik, Marta Kwiatkowska, Agnieszka Robaszkiewicz
    Book:
    Badania i Rozwój Młodych Naukowców w Polsce: Nauki Medyczne i Nauki o Zdrowiu (year: 2015, volume: 1, pages: 165-172), Publisher: Młodzi Naukowcy, ISBN: 978-83-942083-1-8
    Status:
    Published

  3. Modyfikacje epigenetyczne a rozwój transformacji nowotworowej.

    Authors:
    Ewelina Wiśnik, Marta Kwiatkowska, Agnieszka Robaszkiewicz
    Book:
    Badania i Rozwój Młodych Naukowców w Polsce: Nauki Medyczne i Nauki o Zdrowiu (year: 2015, volume: 1, pages: 173-178), Publisher: Młodzi Naukowcy: ISBN: 978-83-942083-1-8
    Status:
    Published

  4. The search for molecular principles of PARP1 expression: in silico study.

    Authors:
    Agnieszka Robaszkiewicz, Ewelina Wiśnik
    Book:
    Badania i Rozwój Młodych Naukowców w Polsce: Nauki Przyrodnicze (year: 2015, volume: 1, pages: 131-137), Publisher: Młodzi Naukowcy, ISBN: 978-83-942083-1-8
    Status:
    Published

  5. Inhibitory enzymów modyfikujących histony jako narzędzia służące modulowaniu ekspresji genów determinujących pluripotencję komórek macierzystych oraz procesu różnicowania

    Authors:
    Agnieszka Robaszkiewicz
    Book:
    Innowacje w polskiej nauce w obszarze life science i ochrony środowiska Przegląd aktualnej tematyki badawczej (year: 2016, volume: 1, pages: 46157), Publisher: Wydawnictwo Nauka i Biznes
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski