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Studies on the mechanism and applications of the chemoenzymatic rearrangement reaction of the unsaturated carboxylic acids.

2013/11/B/ST5/02199

Keywords

Descriptors

  • ST4_11: Nowoczesne metody prowadzenia reakcji i procesów
  • ST5_18: Kataliza homogeniczna i heterogeniczna
  • ST4_14: Reakcje chemiczne: mechanizmy, termodynamika, kinetyka i kataliza

Panel

ST5 – Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution

Instytut Chemii Organicznej Polska Akademia Nauk

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Ryszard Józef Ostaszewski

Number of co-investigators in the project: 5

Call

OPUS 6 – announced on 2013-09-16

Amount awarded
952 460 PLN
Project start date
2014-11-03
Project end date
2018-01-02
Project duration
38 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Inkubator z wytrzasaniem.
  2. Mieszadła magnetyczne (dwa zestawy) (2 pcs). Cost: 6 000 PLN
  3. SYSTEM DO CHROMATOGRAFII ŻELOWEJ FLASH WRAZ Z WYPOSAŻENIEM (kardridże, detektor z detekcją laserową). Cost: 195 000 PLN
  4. Wirówka. Cost: 5 000 PLN

Information in the final report

Publication in academic press/journals (12)

  1. Evaluation of a new protocol for enzymatic dynamic kinetic resolution of 3-hydroxy-3-(aryl)propanoic acids

    Authors:
    D. Koszelewski, M. Zysk, A. Brodzka, A. Żądło, D. Paprocki, R. Ostaszewski
    Academic press:
    Organic & Biomolecular Chemistry (year: 2015, volume: 13, pages: 11014-11020), Publisher: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5ob01380a – link to the publication

  2. Studies on asymmetric synthesis of bicyclomycin precursors. A chemoenzymatic route to chiral 2,5-diketopiperazines and 2-oxa-bicyclo[4.2.2]decane-8,10-diones

    Authors:
    A. Fryszkowska, D. Kolszelewski, R. Ostaszewski
    Academic press:
    Tetrahedron Asymmetry (year: 2017, volume: 28, pages: 1127-1134), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.08.004 – link to the publication

  3. A Convenient Stereoselective Synthesis of 5-Hydroxy-3-oxoesters and 3-Hydroxy-5-oxoesters

    Authors:
    A. Żadło-Dobrowolska, J. H. Schrittwieser, B. Grischek, D. Koszelewski, W. Kroutil, R. Ostaszewski
    Academic press:
    Tetrahedron Asymmetry (year: 2017, volume: 28, pages: 797-802), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.05.005 – link to the publication

  4. Enzyme mediated kinetic resolution of δ-hydroxy-α,β-unsaturated esters as a route to optically active δ-lactones

    Authors:
    D. Koszelewski, D. Paprocki, A. Brodzka, R. Ostaszewski
    Academic press:
    Tetrahedron Asymmetry (year: 2017, volume: 28, pages: 809-818), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.05.003 – link to the publication

  5. Mixed Carbonates as Useful Substrates for a Fluorogenic Assay for Lipases and Esterases

    Authors:
    A. Żądło, D. Koszlewski, F. Borys, R. Ostaszewski
    Academic press:
    ChemBioChem (year: 2015, volume: 16, pages: 677-682), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.201402528 – link to the publication

  6. Dynamic Kinetic Resolution of 3-aryl-4-Pentenoic Acids

    Authors:
    D. Koszelewski, A. Brodzka, A. Żądło, D. Paprocki D., D. Trzepizur , M. Zysk, R. Ostaszewski
    Academic press:
    ACS Catal. (year: 2016, volume: 6, pages: 3287-3292), Publisher: AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
    Status:
    Published
    DOI:
    10.1021/acscatal.6b00271 – link to the publication

  7. The mechanistic promiscuity of the enzymatic esterification of chiral carboxylic acids

    Authors:
    A. Brodzka, D. Koszelewski, M. Zysk, R. Ostaszewski
    Academic press:
    Catalysis Communications (year: 2018, volume: 106, pages: 82-86), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.catcom.2017.12.019 – link to the publication

  8. Enzymatic synergism in the synthesis of β-keto esters

    Authors:
    C. Wiśniewska, D. Koszelewski, M. Zysk, , S. Kłossowski, A. Żądło, A. Brodzka and R. Ostaszewski
    Academic press:
    European Journal of Organic Chemistry (year: 2015, volume: 24, pages: 5432-5437), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/ejoc.201500676 – link to the publication

  9. Evaluation of Pseudoenantiomeric Mixed Carbonates as Efficient Fluorogenic Probes for Enantioselectivity Screening

    Authors:
    A. Żądło, D. Koszlewski, F. Borys, R. Ostaszewski
    Academic press:
    ChemBioChem (year: 2016, volume: 17, pages: 71-76), Publisher: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.201500509 – link to the publication

  10. Self-immolative Versatile Fluorogenic Probes for Screening of Hydrolytic Enzymes Activity

    Authors:
    A. Żądło, M. Szczygieł, D. Koszelewski, D. Paprocki, R. Ostaszewski,
    Academic press:
    Organic & Biomolecular Chemistry (year: 2016, volume: 14, pages: 9146-9150), Publisher: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/C6OB01488G – link to the publication

  11. Polymer membrane ion-selective electrodes as a convenient tool for lipases and esterases assays

    Authors:
    M. Cieplak, R. Ostaszewski
    Academic press:
    Preparative Biochem. Biotech., (year: 2017, volume: 47, pages: 673-677), Publisher: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/10826068.2017.1303611 – link to the publication

  12. Intracolonic Hydrogen Sulfide Lowers Blood Pressure in Rat

    Authors:
    L. Tomasova; L. Dobrowolski, H. Jurkowa, M. Wróbel, T. Huc, K. Ondaris, R. Ostaszewski, M. Ufnal
    Academic press:
    Nitric Oxide (year: 2016, volume: 14, pages: 50-58), Publisher: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
    Status:
    Published
    DOI:
    10.1016/j.niox.2016.09.007 – link to the publication

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