Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Regulation of protein antigen-induced immune response by T CD8+ suppressor lymphocyte exosomes - the suppression of active course of delayed-type hypersensitivity reaction.

2013/11/B/NZ6/02041

Keywords:

miRNA-150 exosomes immune suppression T CD8+ suppressor lymphocytes B1 lymphocytes delayed-type hypersensitivity

Descriptors:

  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krzysztof Bryniarski 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 650 600 PLN

Project start date (Y-m-d): 2014-07-16

Project end date (Y-m-d): 2018-07-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. pH-metr EC 45-pH wraz z elektrodą (4 593 PLN)
  2. Wirówka laboratoryjna stołowa z chłodzeniem (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (4)
  1. A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.
    Authors:
    Askenase PW, Bryniarski K, Paliwal V, Redegeld F, Groot Kormelink T, Kerfoot S, Hutchinson AT, van Loveren H, Campos R, Itakura A, Majewska-Szczepanik M, Yamamoto N, Nazimek K, Szczepanik M, Ptak W
    Academic press:
    Annals of New York Academy of Sciences (rok: 2015, tom: 1362, strony: 200-214), Wydawca: John Wiley & Sons, Inc.
    Status:
    Published
    DOI:
    10.1111/nyas.12975. - link to the publication
  2. Orally Administered Exosomes Suppress Mouse Delayed-Type Hypersensitivity by Delivering miRNA-150 to Antigen-Primed Macrophage APC Targeted by Exosome-Surface Anti-Peptide Antibody Light Chains
    Authors:
    Nazimek K, Bryniarski K, Ptak W, Groot Kormelink T, Askenase PW.
    Academic press:
    International Journal of Molecular Sciences (rok: 2020, tom: 21, strony: E5540), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms21155540 - link to the publication
  3. Extracellular miRNA Functionally Targets Cells by Transfecting Exosomes from Their Companion Cells.
    Authors:
    Bryniarski K, Ptak W, Martin E, Nazimek K, Szczepanik M, Sanak M, Askenase PW
    Academic press:
    PLoS One (rok: 2015, tom: Apr 29;10(4):, strony: e0122991), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0122991. - link to the publication
  4. Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity.
    Authors:
    Nazimek K, Bryniarski K, Askenase PW
    Academic press:
    International Archives of Allergy and Immunology (rok: 2016, tom: 171, strony: 45317), Wydawca: S. Krager AG, Basel
    Status:
    Published
    DOI:
    10.1159/000449249 - link to the publication
  5. From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor.
    Authors:
    Ptak W, Nazimek K, Askenase PW, Bryniarski K
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2015, tom: 63, strony: 345-356), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-015-0331-4 - link to the publication
  6. Exosomes as mediators of intercellular communication: clinical implications.
    Authors:
    Nazimek K, Bryniarski K, Santocki M, Ptak W
    Academic press:
    Polskie Archivum Medycyny Wewnętrznej (rok: 2015, tom: 125, strony: 370-380), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    brak - link to the publication
  7. Enhanced generation of reactive oxygen intermediates by suppressor T cell-derived exosome-treated macrophages.
    Authors:
    Nazimek K, Nowak B, Marcinkiewicz J, Ptak M, Ptak W, Bryniarski K
    Academic press:
    Folia Medica Cracoviensia (rok: 2014, tom: 54, strony: 37-52), Wydawca: Oddział PAN w Krakowie, Uniwersytet Jagielloński Collegium Medicum
    Status:
    Published
    DOI:
    brak - link to the publication
  8. The role of medicaments, exosomes and miRNA molecules in modulation of macrophage immune activity.
    Authors:
    Nazimek K, Filipczak-Bryniarska I, Bryniarski K
    Academic press:
    Postepy Higieny i Medycyny Doswiadczalnej (rok: 2015, tom: 69, strony: 1114-1129), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    brak - link to the publication
  1. Antigen-specific exosomes carrying miRNA-150 interact with ovalbumin-derived peptides to suppress the delayed-type hypersensitivity reaction in mice.
    Authors:
    Bryniarski K, Nazimek K, Ptak M, Ptak W, Askenase PW
    Conference:
    International Congress of Immunology, Melbourne, Austarlia (rok: 2016, ), Wydawca: European Journal of Immunology
    Data:
    konferencja 21-26 August
    Status:
    Published
  2. Free extracellular miRNA associating with exosomes to precisely target cells as significant contributors to immunoregulation.
    Authors:
    Bryniarski K
    Conference:
    The XVIth Congress of Polish Society of Experimental and Clinical Immunology, Warszawa (rok: 2017, ), Wydawca: Central European Journal of Immunology
    Data:
    konferencja June 8-10,
    Status:
    Published
  3. Macrophages affected with exosome-carried miRNA-150 release secondary vesicles to inhibit the proliferation of effector T lymphocytes of mouse contact and delayed-type hypersensitivity.
    Authors:
    Nazimek K, Ptak M, Ptak W, Askenase PW, Bryniarski K
    Conference:
    International Congerss of Immunology, Melbourne, Australia (rok: 2016, ), Wydawca: European Journal of Immunology
    Data:
    konferencja 21-26 August
    Status:
    Published
  4. miRNA-150 carried by antigen-specific exosomes alleviate symptoms of delayed-type and contact hypersensitivity responses in mice.
    Authors:
    Bryniarski K, Nazimek K, Wąsik M, Ptak M, Ptak W
    Conference:
    The XVI-th Congress of Polish Society of Experimental and Clinical Immunology, Warsaw (rok: 2017, ), Wydawca: Central European Journal of Immunology
    Data:
    konferencja June 8-10,
    Status:
    Published

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