Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Foldamer-based artificial enzymes

2013/10/E/ST5/00625

Keywords:

foldamers enzymatic catalysis hydrolases

Descriptors:

  • ST5_22:
  • ST5_18:
  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Wrocławska, Wydział Chemiczny

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Łukasz Berlicki 

Number of co-investigators in the project: 8

Call: SONATA BIS 3 - announced on 2013-06-14

Amount awarded: 1 496 840 PLN

Project start date (Y-m-d): 2014-05-07

Project end date (Y-m-d): 2017-05-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. automatyczny sentezator peptydów z mikrofalami (300 000 PLN)
  2. komputer osobisty z monitorem 3szt.
  3. pompa próżniowa.
  4. Aparat do preparatywnej wysokosprawnej chromatografii cieczowej (HPLC) (200 000 PLN)
  5. Drukarka 3d.

Information in the final report

  • Publication in academic press/journals (5)
  1. Peptides containing beta-amino acid patterns—challenges and successes in medicinal chemistry
    Authors:
    Cabrele, C.; Martinek, T. A.; Reiser, O.; Berlicki, Ł.
    Academic press:
    Journal of Medicinal Chemistry (rok: 2014, tom: 57, strony: 9718-9739), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jm5010896 - link to the publication
  2. Peptide-based inhibitors of protein–protein interactions
    Authors:
    Wójcik, P.; Berlicki, Ł.
    Academic press:
    Bioorganic and Medicinal Chemistry Letters (rok: 2016, tom: 26, strony: 707-713), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.12.084 - link to the publication
  3. Controlling the Helix Handedness of ααβ-Peptide Foldamers through Sequence Shifting
    Authors:
    Szefczyk, M.; Węglarz-Tomczak, E.; Fortuna, P.; Krzysztoń, A.; Rudzińska-Szostak, E.; Berlicki, Ł.
    Academic press:
    Angew. Chem. Int. Ed. (rok: 2017, tom: 56, strony: 2087-2091), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/anie.201610154 - link to the publication
  4. Helix-loop-helix peptide foldamers and their use in the construction of hydrolase mimetics.
    Authors:
    Drewniak, M.; Węglarz-Tomczak, E.; Ożga, K.; Rudzińska-Szostak, E.; Macegoniuk, K.; Tomczak, J. M.; Bejger, M.; Rypniewski, W.; Berlicki, Ł.
    Academic press:
    Bioorganic Chemistry (rok: 2018, tom: 81, strony: 356-361), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioorg.2018.07.012 - link to the publication
  5. Sequence engineering to control the helix handedness of peptide foldamers
    Authors:
    Ewa Rudzińska-Szostak, Łukasz Berlicki
    Academic press:
    Chemistry - a European Journal (rok: 2017, tom: 23, strony: 14980 - 14986), Wydawca: Wiley VCH
    Status:
    Published
    DOI:
    10.1002/chem.201702730 - link to the publication

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