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Neuronal and nonneuronal mechanisms of Bont/A effects in neuropathic pain development - behavioral and biochemical studies

2013/10/M/NZ4/00261

Keywords:

neuropathic pain botulinum toxin type A microglia astroglia

Descriptors:

  • NZ4_4: Pathophysiology
  • NZ4_7: Neurophysiology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Joanna Mika 

Number of co-investigators in the project: 8

Call: HARMONIA 5 - announced on 2013-06-14

Amount awarded: 1 111 749 PLN

Project start date (Y-m-d): 2014-06-04

Project end date (Y-m-d): 2018-09-03

Project duration:: 51 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (18)
  • Articles in post-conference publications (20)
  1. Blockade of IL-18 signaling diminished neuropathic pain and enhanced the efficacy of morphine and buprenorphine.
    Authors:
    Pilat D, Piotrowska A, Rojewska E, Jurga A, Ślusarczyk J, Makuch W, Basta-Kaim A, Przewlocka B, Mika J.
    Academic press:
    Mol Cell Neurosci. (rok: 2016, tom: 71, strony: 114-124), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mcn.2015.12.013 - link to the publication
  2. Blockade of Toll-Like Receptors (TLR2, TLR4) Attenuates Pain and Potentiates Buprenorphine Analgesia in a Rat Neuropathic Pain Model
    Authors:
    Jurga A.M., Rojewska E., Piotrowska A., Makuch W., Pilat D., Przewlocka B., Mika J.
    Academic press:
    Neural Plasticity (rok: 2016, tom: 2016 ID5238730, strony: 45303), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2016/5238730 - link to the publication
  3. Direct and indirect pharmacological modulation of CCL2/CCR2 pathway results in attenuation of neuropathic pain - In vivo and in vitro evidence.
    Authors:
    Piotrowska A., Kwiatkowski K., Rojewska E., Slusarczyk J., Makuch W., Basta-Kaim A., Przewlocka B, Mika J.
    Academic press:
    J Neuroimmunol. (rok: 2016, tom: 297, strony: 45554), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jneuroim.2016.04.017 - link to the publication
  4. Participation of pro-and anti-nociceptive interleukins in botulinum toxin A analgesia in rat neuropathic pain model
    Authors:
    Zychowska M., Rojewska E., Makuch W., Luvisetto S., Pavone F., Marinelli S., Przewlocka B., Mika J.
    Academic press:
    Eur J Pharmacol. (rok: 2016, tom: 791, strony: 377-388), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2016.09.019 - link to the publication
  5. Targeting the microglial signaling pathways: new Insights in the modulation of neuropathic pain
    Authors:
    Popiołek-Barczyk K.; Mika J.
    Academic press:
    Current Medicinal Chemistry (rok: 2016, tom: 23, strony: 2908-2928), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/0929867323666160607120124 - link to the publication
  6. Lipopolysaccharide from Rhodobacter sphaeroides (TLR4 antagonist) attenuates hypersensitivity and modulates nociceptive factors
    Authors:
    A.Jurga, E. Rojewska, W. Makuch, J. Mika
    Academic press:
    Pharmaceutical Biology (rok: 2018, tom: 56, strony: 275–286), Wydawca: Taylor and Francis
    Status:
    Published
    DOI:
    10.1080/13880209.2018.1457061 - link to the publication
  7. Modification of neuroimmunological interactions by minocycline: experimental background for neuropathic pain treatment.
    Authors:
    Rojewska E., Popiołek-Barczyk K., Starnowska J., Przewłocka B., Mika J.
    Academic press:
    Annual Report, Polish Academy of Sciences (rok: 2015, tom: -, strony: 75-78), Wydawca: Polish Academy of Sciences PKiN, Warszawa
    Status:
    Published
    DOI:
    brak - link to the publication
  8. The RS504393 influences the level of nociceptive factors and enhances opioid analgesic potency in neuropathic rats
    Authors:
    Kwiatkowski K., Piotrowska A., Rojewska E., Makuch W., Mika J.
    Academic press:
    The Journal of Neuroimmune Pharmacology (rok: 2017, tom: 12, strony: 402-419), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11481-017-9729-6 - link to the publication
  9. Botulinum Toxin Type A-A Modulator of Spinal Neuron-Glia Interactions under Neuropathic Pain Conditions
    Authors:
    Rojewska E, Piotrowska A, Popiolek-Barczyk K, Mika J.
    Academic press:
    Toxins (Basel) (rok: 2018, tom: 10, strony: 45303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/toxins10040145 - link to the publication
  10. Nowe sposoby leczenia bólu - modulacja aktywności komórek glejowych: Marawirok jako modulator polaryzacji komórek glejowych – badania in vivo i in vitro
    Authors:
    Piotrowska A., Kwiatkowski K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Artykuł popularnonaukowy wysłany do publikacji na stronie Instytutu Farmakologii Polskiej Akademii Nauk (rok: 2018, tom: -, strony: 1), Wydawca: IF PAN
    Status:
    Published
    DOI:
    brak - link to the publication
  11. Biphalin, a dimeric enkephalin, alleviates LPS-induced activation in rat primary microglial cultures in opioid receptor-dependent and -independent manners
    Authors:
    Popiolek-Barczyk K., Piotrowska A., Makuch W., Mika J.
    Academic press:
    Neural Plast. (rok: 2017, tom: 2017, strony: 45310), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/3829472 - link to the publication
  12. Dataset of botulinum toxin A influence on interleukins under neuropathy
    Authors:
    Zychowska M., Rojewska E., Makuch W., Luvisetto S., Pavone F, Marinelli S, Przewlocka B, Mika J.
    Academic press:
    Data in Brief (rok: 2016, tom: 9, strony: 1020-1023), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.dib.2016.11.023 - link to the publication
  13. Jak chroniczny ból zmienia ekspresję genów:
    Authors:
    Rojewska E., Piotrowska A., Makuch W., Przewlocka B., Mika J.
    Academic press:
    Artykuł popularnonaukowy wysłany do publikacji na stronie Instytutu Farmakologii Polskiej Akademii Nauk (rok: 2018, tom: -, strony: 1), Wydawca: IF PAIN
    Status:
    Published
    DOI:
    - - link to the publication
  14. Marawirok jako potencjalny lek stosowany w terapii bólu neuropatycznego – dowody z badań podstawowych
    Authors:
    Kwiatkowski K, Piotrowska A, Mika J.
    Academic press:
    Ból (rok: 2015, tom: 16, strony: 31-36), Wydawca: Index Copernicus
    Status:
    Published
    DOI:
    10.5604/1640324x.1193855 - link to the publication
  15. Blockade of P2X4 receptors inhibits neuropathic pain-related behavior by preventing MMP-9 activation and, consequently, pronociceptive interleukin release in a rat model.
    Authors:
    Jurga A.M., Piotrowska A., Makuch W., Przewlocka B. Mika J.
    Academic press:
    Front. Pharmacol. (rok: 2017, tom: 8, strony: 45309), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fphar.2017.00048 - link to the publication
  16. Comparison of the expression changes after botulinum toxin type A and minocycline administration in lipopolysaccharide-stimulated rat microglial and astroglial cultures
    Authors:
    Piotrowska A., Popiołek-Barczyk K., Pavone F., Mika J.
    Academic press:
    Front Cell Infect Microbiol. (rok: 2017, tom: 7, strony: 45308), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcimb.2017.00141. - link to the publication
  17. Maraviroc reduces neuropathic pain through polarization of microglia and astroglia - evidence from in vivo and in vitro studies
    Authors:
    Piotrowska A., Kwiatkowski K., Rojewska E., Makuch W., Mika J.
    Academic press:
    Neuropharmacology (rok: 2016, tom: 108, strony: 207-19), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuropharm.2016.04.024 - link to the publication
  18. Pharmacological kynurenine 3-monooxygenase enzyme inhibition significantly reduces neuropathic pain in a rat model.
    Authors:
    Rojewska E, Piotrowska A, Makuch W, Przewlocka B, Mika J.
    Academic press:
    Neuropharmacology (rok: 2016, tom: 102, strony: 80-91), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.040 - link to the publication
  1. Administration of CORM-2 (P2X4R antagonist) diminished pain and the level of pronociceptive factors in rat model of neuropathy.
    Authors:
    Jurga AM., Piotrowska A., Starnowska J., Makuch W., Przewlocka B., Mika J.
    Conference:
    10 FENS Forum of Neuroscience (rok: 2016, ), Wydawca: The Federation of European Neuroscience Societes (FENS)
    Data:
    konferencja 2-6.07.2016 Kopenhaga
    Status:
    Published
    DOI:
    link to the publication
  2. Maraviroc by polarization of microglia and astroglia reducing pain in rat model of neuropathy -evidences from in vivo and in vitro studies
    Authors:
    Piotrowska A, Kwiatkowski K., Rojewska E., Makuch W., Jurga A.M., Ślusarczyk J., Trojan E., Basta-Kaim A., Mika J.
    Conference:
    2nd Central European Biomedical Congress (CEBC) (rok: 2016, ), Wydawca: CEBC, Kraków
    Data:
    konferencja 15-18.06.2016, Kraków
    Status:
    Published
    DOI:
    link to the publication
  3. Pharmacological modulation of kynurenic pathway by Ro61-6048 and JM6 significantly diminishes neuropathic pain symptoms
    Authors:
    Rojewska E., Piotrowska-Murzyn A., Makuch W., Przewlocka B., Mika J.
    Conference:
    6th International Congress on Neuropathic Pain (rok: 2017, ), Wydawca: NEUPSIG, Goteborg
    Data:
    konferencja 15-18.06.2017
    Status:
    Published
  4. The CCR2 antagonist, RS504393, attenuates neuropathic pain symptoms and enhances opioid effectiveness
    Authors:
    Kwiatkowski K., Rojewska E., Makuch W., Piotrowska A., Mika J.
    Conference:
    2nd Central European Biomedical Congress (CEBC) (rok: 2016, ), Wydawca: CEBC, Kraków
    Data:
    konferencja 15-18.06.2016, Kraków
    Status:
    Published
    DOI:
    link to the publication
  5. Administration of P2X4 receptor antagonist (CORM-2) inhibits neuropathic pain and improves opioid effectiveness in rats.
    Authors:
    Jurga A., Piotrowska A., Starnowska J., Makuch W., Przewlocka B., Mika J.
    Conference:
    European Pain School (rok: 2016, ), Wydawca: IASP
    Data:
    konferencja 5-12.06.2016 Siena
    Status:
    Published
    DOI:
    link to the publication
  6. Inhibition of glial activation by minocycline modifies the effects of botulinum neurotoxin a in a model of neuropathic pain.
    Authors:
    Mika J., Rojewska E., Makuch W., Marinelli S., Luvisetto S., Pavone F., Przewlocka B.
    Conference:
    9th Congress of the European Pain Federation EFIC (rok: 2015, ), Wydawca: European Pain Federation EFIC
    Data:
    konferencja 2-5.09.2015 Wieden
    Status:
    Published
    DOI:
    link to the publication
  7. The RS504393 (CCR2 antagonist) modulates neuropathic pain via CCR2/CCL2 and glial signaling pathways in CCI-exposed rats
    Authors:
    Kwiatkowski K., Rojewska E., Makuch W., Mika J.
    Conference:
    NEURONUS 2016, IBRO&IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus, Kraków
    Data:
    konferencja 22-24.04.2016, Kraków
    Status:
    Published
    DOI:
    link to the publication
  8. Effect of botulinum toxin type A and minocycline on lipopolysaccharide-stimulated rat microglial and astroglial cultures
    Authors:
    Piotrowska-Murzyn A., Popiołek-Barczyk K., Pavone F., Mika J.
    Conference:
    XII European Meeting on Glial Cells in Health and Disease (rok: 2017, ), Wydawca: Network Glia
    Data:
    konferencja 08-11.07.2017
    Status:
    Published
  9. Minocycline enhance botulinum neurotoxin A analgesia under neuropathic pain via glia modulation.
    Authors:
    Makuch W., Rojewska E., Zychowska M., Marinelli S., Luvisetto S., Pavone F., Przewlocka B., Mika J.
    Conference:
    Neurochemical conference, Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics" (rok: 2015, ), Wydawca: IMDIK PAN
    Data:
    konferencja 22-23.10. 2015 Warszawa
    Status:
    Published
    DOI:
    link to the publication
  10. Pharmacological modulation of purinergic P2X4R reverts neuropathic pain-related behavior, improves opioid effectiveness and influences nociceptive factors in rat model /Modulacja receptora purynergicznego P2X4R zapobiega objawom bólu neuropatycznego, podnosi efektywność opioidów oraz moduluje poziom czynników nocyceptywnych w szczurzym modelu.
    Authors:
    Jurga A. M., Piotrowska A., Starnowska J., Makuch W., Przewlocka B., Mika J.
    Conference:
    European Pain Federation Pain School 2017 (rok: 2017, ), Wydawca: Index-Copernicus
    Data:
    konferencja 25-29.06.2017
    Status:
    Published
  11. The study of influence of minocycline on Botulinum toxin A on pro-and antinociceptive intereleukins under neuropathic pain.
    Authors:
    Rojewska E., Zychowska M., Makuch W., Marinelli S., Luvisetto S., Pavone F., Przewlocka B., Mika J.
    Conference:
    Neurochemical conference, Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics". (rok: 2015, ), Wydawca: IMDIK PAN
    Data:
    konferencja 22-23.10. 2015 Warszawa
    Status:
    Published
    DOI:
    link to the publication
  12. Biphalin, a dimeric enkephalin, alleviates LPS-induced activation in rat primary microglial cultures in opioid receptor-dependent and -independent manners
    Authors:
    Popiołek-Barczyk K., Piotrowska-Murzyn A., Makuch W., Mika J.
    Conference:
    XII European Meeting on Glial Cells in Health and Disease (rok: 2017, ), Wydawca: Network Glia
    Data:
    konferencja 08-11.07.2017
    Status:
    Published
  13. IL-1 family – how blockage of IL-1beta and IL-18 signalling diminished neuropathic pain and enhanced the efficacy of morphine.
    Authors:
    Pilat D., Piotrowska A., Rojewska E., Jurga A., Makuch W., Przewlocka B., Mika J.
    Conference:
    NEURONUS 2016, IBRO&IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus, Kraków
    Data:
    konferencja 22-24.04.2016, Kraków
    Status:
    Published
    DOI:
    link to the publication
  14. Interleukin-18 binding protein: a novel modulation of neuropathic pain.
    Authors:
    Piotrowska A., Pilat D., Rojewska E., Jurga A., Ślusarczyk J., Makuch W., Basta-Kaim A., Przewlocka B., Mika J.
    Conference:
    10 FENS Forum of Neuroscience (rok: 2016, ), Wydawca: The Federation of European Neuroscience Societes (FENS)
    Data:
    konferencja 2-6.07.2016 Kopenhaga
    Status:
    Published
    DOI:
    link to the publication
  15. Maraviroc, CCR5 anatagonist, influences the activation of various signaling pathways and exhibits an analgesic in rat model of neuropathy -in vivo and in vitro studies
    Authors:
    Piotrowska-Murzyn A., Kwiatkowski K., Rojewska E., Makuch W., Jurga AM., Ślusarczyk J., Trojan E., Basta-Kaim A., Mika J.
    Conference:
    6th International Congress on Neuropathic Pain (rok: 2017, ), Wydawca: NEUPSIG, Goteborg
    Data:
    konferencja 15-18.06.2017
    Status:
    Published
  16. The influence of BoNT/A administration on IL-1 family members in rat neuropathic pain model – in vivo and in vitro evidences
    Authors:
    Zychowska M., Piotrowska A., Rojewska E., Makuch W., Marinelli S., Luvisetto S., Pavone F., Przewlocka B., Mika J.
    Conference:
    2nd Central European Biomedical Congress (CEBC) (rok: 2016, ), Wydawca: CEBC, Kraków
    Data:
    konferencja 15-18.06.2016 Kraków
    Status:
    Published
    DOI:
    link to the publication
  17. The neuropathic pain symptoms attenuation thru neuroimmunological changes induced by botulinum toxin type A administration. / Łagodzenie symptomów bólu neuropatycznego poprzez zmiany w poziomie czynników neuroimmunologicznych wywołane podaniem toksyny botulinowej typu A
    Authors:
    Zychowska M., Piotrowska A., Rojewska E., Makuch W., Marinelli S., Luviseto S., Pavone F., Przewlocka B., Mika J.
    Conference:
    European Pain Federation Pain School 2017 (rok: 2017, ), Wydawca: Index-Copernicus
    Data:
    konferencja 25-29.06.2017
    Status:
    Published
  18. Inhibition of SNAP-25 and glial activation advantages and disadvantages under neuropathic pain.
    Authors:
    Piotrowska A., Rojewska E., Makuch W., Marinelli S., Luvisetto S., Pavone F., Zychowska M., Przewlocka B., Mika J.
    Conference:
    Translational Pain Research: From lab to clinic (rok: 2015, ), Wydawca: Kraków, EFIC
    Data:
    konferencja 5-9.07.2015 Kraków
    Status:
    Published
    DOI:
    link to the publication
  19. Pharmacological antagonism of TLR4 and P2X4R potentiates opioid anagesia in rat neuropathic pain model
    Authors:
    Jurga A., Piotrowska A., Starnowska J., Makuch W., Przewlocka B., Mika J.
    Conference:
    NEURONUS 2016, IBRO&IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus, Kraków
    Data:
    konferencja 22-24.04.2016, Kraków
    Status:
    Published
    DOI:
    link to the publication
  20. The role of pro- and anti-nociceptive interleukins in botulinum toxin A-induced analgesia under neuropathic pain – in vivo and in vitro study
    Authors:
    Makuch W., Piotrowska-Murzyn A., Rojewska E., Zychowska M., Luvisetto S., Pavone F., Marinelli S., Przewlocka B., Mika J.
    Conference:
    6th International Congress on Neuropathic Pain (rok: 2017, ), Wydawca: NEUPSIG, Goteborg
    Data:
    konferencja 15-18.06.2017
    Status:
    Published

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