Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Fibrin clot properties and their determinants in patients with venous thromboembolism and its recurrence: a contribution of qualitative alterations in the fibrinogen and plasminogen molecules.

2013/09/B/NZ5/00254

Keywords:

fibrin clot fibrinogen plasminogen venous thromboembolism

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Krakowski Szpital Specjalistyczny im. Jana Pawła II

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Anetta Undas 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 940 144 PLN

Project start date (Y-m-d): 2014-06-09

Project end date (Y-m-d): 2017-06-08

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy białek (6 000 PLN)
  2. Urządzenie do półsuchego transferu białek ze zintegrowanym zasilaczem (Trans-Blot Turbo Transfer System, Bio-Rad) (14 000 PLN)
  3. Reometr (260 000 PLN)

Information in the final report

  • Publication in academic press/journals (22)
  1. Altered Fibrin Clot Properties in Patients With Cerebral Venous Sinus Thrombosis: Association With the Risk of Recurrence
    Authors:
    Siudut J, Świat M, Undas A
    Academic press:
    Stroke (rok: 2015, tom: 46, strony: 2665-2668), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/STROKEAHA.115.009528 - link to the publication
  2. Determinants of the elevated factor VIII activity in patients following venous thromboembolism
    Authors:
    Lech M, Kościelniak B, Bryk AH, Undas A
    Academic press:
    Przegląd Lekarski (rok: 2016, tom: 73, strony: 210-215), Wydawca: Przegląd Lekarski
    Status:
    Published
    DOI:
    brak - link to the publication
  3. Faster fibrin clot degradation characterizes patients with central pulmonary embolism at a low risk of recurrent peripheral embolism
    Authors:
    Kupis RW, Goldman-Mazur S, Polak M, Ząbczyk M, Undas A
    Academic press:
    Sci Rep (rok: 2019, tom: 9, strony: 72), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-37114-4 - link to the publication
  4. Iron deficiency: a novel risk factor of recurrence in patients after unprovoked venous thromboembolism
    Authors:
    Potaczek DP, Jankowska EA, Wypasek E, Undas A
    Academic press:
    Pol Arch Med Wewn (rok: 2016, tom: 126, strony: 159-165), Wydawca: Medycyna Praktyczna
    Status:
    Published
    DOI:
    10.20452/pamw.3311 - link to the publication
  5. Altered Plasma Clot Properties and Trauma-Related Venous Thromboembolism despite Thromboprophylaxis
    Authors:
    Goldman S, Frączek P, Szklanny K, Papuga-Szela E, Stanisz A, Undas A
    Academic press:
    Thromb Haemost (rok: 2018, tom: 118, strony: 654-663), Wydawca: Thieme
    Status:
    Published
    DOI:
    10.1055/s-0038-1636535 - link to the publication
  6. Altered plasma clot properties increase the risk of recurrent deep vein thrombosis: a cohort study
    Authors:
    Cieslik J, Mrozinska S, Broniatowska E, Undas A
    Academic press:
    Blood (rok: 2018, tom: 131, strony: 797-807), Wydawca: American Society of Hematology
    Status:
    Published
    DOI:
    10.1182/blood-2017-07-798306 - link to the publication
  7. Antithrombin Rouen IV mutation in Polish patient with deep vein thrombosis
    Authors:
    Brutkowski K, Wypasek E, Corral J, Undas A
    Academic press:
    Acta Haematologica Polonica (rok: 2015, tom: 46, strony: 393-395), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.001 - link to the publication
  8. Heavy menstrual bleeding in women treated with rivaroxaban and vitamin K antagonists and the risk of recurrent venous thromboembolism
    Authors:
    Bryk AH, Piróg M, Plens K, Undas A
    Academic press:
    Vascul Pharmacol (rok: 2016, tom: 87, strony: 242-247), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vph.2016.11.003 - link to the publication
  9. How to assess fibrinogen levels and fibrin clot properties in clinical practice?
    Authors:
    Undas A
    Academic press:
    Semin Thromb Hemost (rok: 2016, tom: 42, strony: 381-388), Wydawca: Thieme
    Status:
    Published
    DOI:
    10.1055/s-0036-1579636 - link to the publication
  10. Plasma fibrin clot properties in the G20210A prothrombin mutation carriers following venous thromboembolism: the effect of rivaroxaban
    Authors:
    Janion-Sadowska A, Natorska J, Siudut J, Zabczyk M, Stanisz A, Undas A
    Academic press:
    Thromb Haemost (rok: 2017, tom: 117, strony: 1739-1749), Wydawca: Schattauer
    Status:
    Published
    DOI:
    10.1160/TH17-01-0060 - link to the publication
  11. Prothrombotic fibrin clot phenotype is associated with recurrent pulmonary embolism after discontinuation of anticoagulant therapy
    Authors:
    Zabczyk M, Plens K, Wojtowicz W, Undas A
    Academic press:
    Arterioscler Thromb Vasc Biol (rok: 2017, tom: 37, strony: 365-373), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/ATVBAHA.116.308253 - link to the publication
  12. Reduced plasma fibrin clot permeability and susceptibility to lysis are associated with increasedrisk of postthrombotic syndrome
    Authors:
    Siudut J, Grela M, Wypasek E, Plens K, Undas A
    Academic press:
    J Thromb Haemost (rok: 2016, tom: 14, strony: 784-793), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1111/jth.13264 - link to the publication
  13. Reduced plasma fibrin clot permeability is associated with recurrent thromboembolic events in patients with antiphospholipid syndrome
    Authors:
    Celinska-Lowenhoff M, Zabczyk M, Iwaniec T, Plens K, Musiał J, Undas A
    Academic press:
    Rheumatology (Oxford) (rok: 2018, tom: 57, strony: 1340-1349), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/rheumatology/key089 - link to the publication
  14. Venous thromboembolism associated with protein S deficiency due to Arg451* mutation in PROS1 gene: a case report and a literature review
    Authors:
    Wypasek E, Karpinski M, Alhenc-Gelas M, Undas A
    Academic press:
    Journal of Genetics (rok: 2017, tom: 96, strony: 1047-1051), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12041-017-0865-9 - link to the publication
  15. Determinants of Elevated Levels of Natural Anticoagulants in Healthy Subjects
    Authors:
    Kościelniak B, Wypasek E, Undas A
    Academic press:
    Adv Clin Exp Med (rok: 2015, tom: 24, strony: 791-800), Wydawca: Wroclaw Medical University
    Status:
    Published
    DOI:
    10.17219/acem/44361 - link to the publication
  16. Protein N-linked homocysteine is associated with recurrence of venous thromboembolism
    Authors:
    Szlauer A, Mielimonka A, Głowacki R, Borowczyk K, Stachniuk J, Undas A
    Academic press:
    Thromb Res (rok: 2015, tom: 136, strony: 911-916), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.thromres.2015.09.002 - link to the publication
  17. The use of direct oral anticoagulants in 56 patients with antiphospholipid syndrome
    Authors:
    Malec K, Góralczyk T, Undas A
    Academic press:
    Thromb Res (rok: 2016, tom: 152, strony: 93-97), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.thromres.2016.12.009 - link to the publication
  18. Differences in plasma fibrin clot composition in patients with thrombotic antiphospholipid syndrome compared with venous thromboembolism
    Authors:
    Stachowicz A, Zabczyk M, Natorska J, Suski M, Olszanecki R, Korbut R, Wiśniewski JR, Undas A
    Academic press:
    Sci Rep (rok: 2018, tom: 8, strony: 17301), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41598-018-35034-x - link to the publication
  19. Prothrombotic fibrin clot phenotype in patients with deep vein thrombosis and pulmonary embolism: a new risk factor for recurrence
    Authors:
    Undas A
    Academic press:
    BioMed Research International (rok: 2017, tom: 2017, strony: 8196256), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2017/8196256 - link to the publication
  20. Prothrombotic state in patients with a left atrial appendage thrombus of unknown origin and cerebrovascular events
    Authors:
    Meus R, Son M, Sobczyk D, Undas A
    Academic press:
    Stroke (rok: 2016, tom: 47, strony: 1872-1878), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/STROKEAHA.116.012856 - link to the publication
  21. Recurrent venous thromboembolism patients form clots with lower elastic modulus than those formed by patients with non-recurrent disease
    Authors:
    Baker SR, Zabczyk M, Macrae FL, Duval C, Undas A, Ariëns RAS
    Academic press:
    J Thromb Haemost (rok: 2019, tom: 17, strony: 618-626), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jth.14402 - link to the publication
  22. Impaired plasminogen binding in patients with venous thromboembolism: association with protein carbonylation
    Authors:
    Siudut J, Natorska J, Ząbczyk M, Zając D, Seweryn K, Rąpała-Kozik M, Undas A
    Academic press:
    Thrombosis Res (rok: 2018, tom: 163, strony: 45644), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.thromres.2018.01.004 - link to the publication

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