Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Are the complex mixtures of nanomaterials more toxic than single ones?

2013/09/B/NZ7/03934

Keywords:

nanomaterials cytotoxicity genotoxicity apoptosis cellular signalization oxidative stress

Descriptors:

  • NZ7_2: Environment and health risks
  • NZ7_15: Toxicology
  • NZ7_16: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Wsi im. Witolda Chodźki

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Lucyna Kapka-Skrzypczak 

Number of co-investigators in the project: 8

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 743 160 PLN

Project start date (Y-m-d): 2014-02-13

Project end date (Y-m-d): 2018-02-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 (54 000 PLN)
  2. Pojemnik LN2 na próbki (z dozownikiem) (22 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (10)
  1. Nuclear Factor kappa B activation by Ag, Au nanoparticles, CdTe quantum dots or their binary mixtures in HepG2 cells
    Authors:
    Lucyna Kapka-Skrzypczak, Sylwia Męczyńska-Wielgosz, Magdalena Matysiak-Kucharek, Magdalena Czajka, Krzysztof Sawicki, Marcin Kruszewski, Kamil Brzóska
    Academic press:
    Annals of Agricultural and Environmental Medicine (rok: 2020, tom: online first, strony: online first), Wydawca: IRH
    Status:
    Published
    DOI:
    10.26444/aaem/120664 - link to the publication
  2. Zastosowanie nanocząstek i nanomateriałów w medycynie
    Authors:
    Justyna Rzeszutek, Magdalena Matysiak, Magdalena Czajka, Krzysztof Sawicki, Patrycja Rachubik, Marcin Kruszewski, Lucyna Kapka-Skrzypczak
    Academic press:
    Hygeia Public Health (rok: 2014, tom: 49(3), strony: 449-457), Wydawca: Polskie Towarzystwo Higieniczne
    Status:
    Published
  3. Susceptibility of HepG2 Cells to Silver Nanoparticles in Combination with other Metal/Metal Oxide Nanoparticles
    Authors:
    Sylwia Męczyńska‐Wielgosz, Maria Wojewódzka, Magdalena Matysiak‐Kucharek, Magdalena Czajka, Barbara Jodłowska‐Jędrych, Marcin Kruszewski, Lucyna Kapka‐Skrzypczak
    Academic press:
    Materials (rok: 2020, tom: 13 (10), strony: 2211 (1-22)), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ma13102221 - link to the publication
  4. Toxicity of metallic nanoparticles in the central nervous system
    Authors:
    Krzysztof Sawicki, Magdalena Czajka, Magdalena Matysiak-Kucharek, Berta Fal, Bartłomiej Drop, Sylwia Męczyńska-Wielgosz, Katarzyna Sikorska, Marcin Kruszewski, Lucyna Kapka-Skrzypczak
    Academic press:
    Nanotechnol Rev (rok: 2019, tom: 8, strony: 175-200), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/ntrev-2019-0017 - link to the publication
  5. Toxicity of titanium dioxide nanoparticles in central nervous system
    Authors:
    Magdalena Czajka, Krzysztof Sawicki, Katarzyna Sikorska, Sylwia Popek, Marcin Kruszewski, Lucyna Kapka-Skrzypczak
    Academic press:
    Toxicology in Vitro (rok: 2015, tom: 29(5), strony: 1042-52), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.tiv.2015.04.004 - link to the publication
  6. Proteomic approach to nanotoxicity
    Authors:
    Matysiak Magdalena, Kapka-Skrzypczak Lucyna, Brzóska Kamil, Gutleb Arno C, Kruszewski Marcin
    Academic press:
    Journal of Proteomics (rok: 2016, tom: 137, strony: 35-44), Wydawca: ElSEVIER
    Status:
    Published
  1. Cyto- and genotoxicity of nanoparticle binary mixtures on two human cell lines
    Authors:
    Kruszewski Marcin, Matysiak Magdalena, Maria Wojewodzka, Sylwia Meczynska-Wielgosz, Lucyna Kapka-Skrzypczak
    Conference:
    XIV International Congress of Toxicology (rok: 2016, ), Wydawca: ELSEVIER
    Data:
    konferencja 02-06.10.2016
    Status:
    Published
  2. Toxicity of Binary Mixtures of Metal(oxide) Nanoparticles and Quantum Dots in two human cell lines HepG2 And A549
    Authors:
    Lucyna Kapka-Skrzypczak, Sylwia Męczyńska-Wielgosz, Magdalena Matysiak-Kucharek, Maria Wojewódzka, Marcin Kruszewski
    Conference:
    12th International Comet Assay Workshop (ICAW2017) (rok: 2017, ), Wydawca: Oxford Academic
    Data:
    konferencja 27.08-01.09.2017
    Status:
    Published
  3. Comparative toxicity of silver and titanium dioxide nanoparticles, their binary mixture and silver-doped titanium dioxide nanoparticles to mammalian cells
    Authors:
    Sylwia Męczyńska-Wielgosz, Anna Kędziora, Maria Wojewódzka, Lucyna Kapka-Skrzypczak, Marcin Kruszewski
    Conference:
    12th International Comet Assay Workshop (ICAW2017) (rok: 2017, ), Wydawca: Oxford Academic
    Data:
    konferencja 27.08-01.09.2017
    Status:
    Published
  4. Ocena cytotoksycznego działania nanocząstek srebra
    Authors:
    Magdalena Matysiak, Sylwia Męczyńska-Wielgosz, Marcin Kruszewski, Lucyna Kapka-Skrzypczak
    Conference:
    XIII Międzynarodowa Konferencja Naukowo-Szkoleniowa: CZŁOWIEK-ZDROWIE-ŚRODOWISKO (rok: 2015, ), Wydawca: Polskie Towarzystwo Medycyny Środowiskowej
    Data:
    konferencja 5-6.11.2015
    Status:
    Published
  5. Cellular distribution and toxicity of silver and titanium dioxide nanoparticle in A549 and HepG2 cells
    Authors:
    Marcin Kruszewski, Sylwia Męczyńska-Wielgosz, Magdalena Czajka, Krzysztof Sawicki, Lucyna Kapka-Skrzypczak
    Conference:
    6th International Congress: Biomaterials and Nanobiomaterials: Recent Advances Safety - Toxicology and Ecology Issues, BIONANOTOX 2015 (rok: 2015, ), Wydawca: Organizing Committee of BIONANOTOX
    Data:
    konferencja 3-10.05.2015
    Status:
    Published
  6. Formation of oxidative DNA damage corresponds to the long term survival of human cells treated with nanosilver
    Authors:
    Kapka-Skrzypczak Lucyna, Gradzka Iwona, Bartlomiejczyk Teresa, Chwastowska Jadwiga, Sommer Sylwester, Grzelak Agnieszka, Zuberek Mariusz, Lankoff Anna, Wojewodzka Maria, Kruszewski Marcin
    Conference:
    EMBS Micro and Nanotechnology in Medicine Conference "TRANSLATING TECHNOLOGY FROM THE BENCH TO THE BEDSIDE" (rok: 2014, ), Wydawca: IEEE Engineering in Medicine and Biology Society
    Data:
    konferencja 08-12.12.2014
    Status:
    Published
  7. Nanomaterials as genotoxic carcinogens - new players enter the game
    Authors:
    Lucyna Kapka-Skrzypczak, Magdalena Matysiak, Marcin Kruszewski
    Conference:
    V Polski Kongres Genetyki (rok: 2016, ), Wydawca: Polskie Towarzystwo Genetyczne, Polskie Towarzystwo Genetyki Człowieka
    Data:
    konferencja 19-22.10.2016
    Status:
    Published
  8. Silver and titanium dioxide induced DNA damage and repair in three human cell lines
    Authors:
    Lucyna Kapka-Skrzypczak, Magdalena Czajka, Krzysztof Sawicki, Teresa Iwanenko, Sylwester Sommer, Maria Wojewódzka, Marcin Kruszewski
    Conference:
    6th International Congress: Biomaterials and Nanobiomaterials: Recent Advances Safety - Toxicology and Ecology Issues, BIONANOTOX 2015 (rok: 2015, ), Wydawca: Organizing Committee of BIONANOTOX
    Data:
    konferencja 3-10.05.2015
    Status:
    Published
  9. Induction of DNA damage in HepG2 and A549 cells treated with quantum dots, silver and titanium dioxide nanoparticles or their binary mixtures
    Authors:
    Marcin Kruszewski, Magdalena Matysiak, Krzysztof Sawicki, Teresa Iwanenko, Maria Wojewodzka, Lucyna Kapka-Skrzypczak
    Conference:
    NANOinBIO 2016: ADVANCES FOR LIFE & MATERIALS SCIENCE (rok: 2016, ), Wydawca: Organizing Committee of NANOinBIO 2016
    Data:
    konferencja 31.05-05.06.2016
    Status:
    Published
  10. The expression of NF-κB related genes in response to nanosilver is cell type specific and related to the basal activity of NF-κB
    Authors:
    Kruszewski Marcin, Stepkowski Tomasz, Brzoska Kamil, Kapka-Skrzypczak Lucyna
    Conference:
    EMBS Micro and Nanotechnology in Medicine Conference "TRANSLATING TECHNOLOGY FROM THE BENCH TO THE BEDSIDE" (rok: 2014, ), Wydawca: IEEE Engineering in Medicine and Biology Society
    Data:
    konferencja 08-12.12.2014
    Status:
    Published